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4-(1H-benzimidazol-2-yl)thiazole

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Identification
Molecular formula
C10H7N3S
CAS number
4570-36-5
IUPAC name
4-(1H-benzimidazol-2-yl)thiazole
State
State

At room temperature, 4-(1H-benzimidazol-2-yl)thiazole is in a solid state. It appears largely as a powder that is stable under normal conditions, but care should be taken to prevent exposure to conditions that might lead to degradation or volatilization.

Melting point (Celsius)
210.00
Melting point (Kelvin)
483.15
Boiling point (Celsius)
369.00
Boiling point (Kelvin)
642.15
General information
Molecular weight
214.27g/mol
Molar mass
214.2720g/mol
Density
1.3060g/cm3
Appearence

4-(1H-benzimidazol-2-yl)thiazole is typically a light tan to off-white powder. The compound can exhibit some crystallinity owing to its aromatic rings and heterocyclic elements. Under magnification, crystals, if formed, may appear as fine needles or plates. Due to its organic structure, it may be sensitive to light and air, leading to slight color variation over time.

Comment on solubility

Solubility of 4-(1H-benzimidazol-2-yl)thiazole (C10H7N3S)

The solubility of 4-(1H-benzimidazol-2-yl)thiazole is an intriguing aspect of its chemical behavior. This compound exhibits a moderate level of solubility in various solvents, which can be attributed to its structural features. Here are a few key points regarding its solubility:

  • Polarity: The presence of the thiazole and benzimidazole moieties contributes to a certain degree of polar character, which influences its solubility in polar solvents.
  • Solvents: 4-(1H-benzimidazol-2-yl)thiazole tends to dissolve well in:
    • Dimethyl sulfoxide (DMSO)
    • Dimethylformamide (DMF)
    • Aromatic hydrocarbons (to a lesser extent)
  • Temperature Effect: Solubility may increase with temperature, which is common for many organic compounds.
  • pH Dependence: The solubility may vary with changes in pH due to protonation-deprotonation equilibria affecting ionic and neutral forms.

Understanding the solubility of this compound is crucial for its application in various fields, including pharmaceuticals and materials science. As noted, "Solubility is a key parameter in determining the utility and efficacy of a compound across different environments."

Interesting facts

Interesting Facts about 4-(1H-benzimidazol-2-yl)thiazole

The compound 4-(1H-benzimidazol-2-yl)thiazole is a fascinating example of heterocyclic chemistry, with intriguing biological activities and potential applications in various fields. Here are some noteworthy aspects of this compound:

  • Structure and Functionality: This compound features a unique combination of benzimidazole and thiazole rings, which contribute to its chemical versatility. The fused heterocyclic structures are known for enhancing the compound's reactivity and biological activity.
  • Biological Significance: Compounds containing both thiazole and benzimidazole moieties have been investigated for their antimicrobial, anti-inflammatory, and anticancer properties. Studies suggest that they can interfere with cellular mechanisms, making them valuable in pharmacology.
  • Research Applications: Researchers are actively exploring the use of 4-(1H-benzimidazol-2-yl)thiazole in drug design. It's been noted for its potential in targeting specific proteins in disease pathways, showcasing its viability as a lead compound in pharmaceutical development.
  • Analytical Techniques: Characterization of this compound often employs methods such as NMR spectroscopy and mass spectrometry, which help identify its structure and confirm purity. Understanding these techniques is crucial for any chemistry student or researcher.
  • Interdisciplinary Relevance: This compound bridges numerous scientific fields including medicinal chemistry, material science, and agricultural chemistry, demonstrating the interconnectedness of chemistry with real-world applications.

As we continue to delve into the world of chemical compounds, 4-(1H-benzimidazol-2-yl)thiazole serves as a prime example of how seemingly simple molecules can hold vast potential for innovation and discovery.

Synonyms
thiabendazole
148-79-8
Tiabendazole
2-(4-Thiazolyl)benzimidazole
Mintezol
Thiabenzole
Tiabendazol
Equizole
Minzolum
Omnizole
Lombristop
Thibenzole
Nemapan
Thiabendazol
Bovizole
Mintesol
Thibenzol
Pitrizet
Tebuzate
Tiabenda
Eprofil
Mertec
Mertect
Mycozol
Polival
Thiaben
Triasox
Tobaz
Tbdz
Thibenzole att
Top Form Wormer
APL-luster
Thibendole
Bioguard
Testo
2-(4-Thiazolyl)-1H-benzimidazole
Thibenzole 200
Tecto rph
Cropasal
Mertect 160
Sistesan
Ormogal
Storite
Tecto 10P
Tecto 40F
Tecto 60
4-(1H-Benzo[d]imidazol-2-yl)thiazole
Hokustar HP
Drawipas
Thiabendole
Biogard
Tecto
2-(1,3-Thiazol-4-yl)-1H-benzimidazole
4-(2-Benzimidazolyl)thiazole
Mertect lsp
Sanaizol 100
1H-Benzimidazole, 2-(4-thiazolyl)-
Chemviron TK 100
TBZ 60W
Metasol TK 100
Thiabendazolum
Thiabenzazole
Thiprazole
Tiabendazolum
Mintezole
2-(Thiazol-4-yl)benzimidazole
E-Z-Ex
Mertect 340f
Equizole A
Captan T
Tecto B
Helmindrax octelmin
MK 360
Tibimix 20
Tresaderm
Tubazole
2-Thiazole-4-ylbenzimidazole
Hymush
Nemacin
2-(1,3-thiazol-4-yl)-1H-1,3-benzodiazole
Metasol TK-100
Syntol M100
2-(1,3-Thiazol-4-yl)benzimidazole
Equivet TZ
TBZ 6
Benzimidazole, 2-(4-thiazolyl)-
Arbotect
2-(4'-Thiazolyl)benzimidazole
MK-360
Thiabendazole [BSI:ISO]
Mintezol (TN)
Thiabendazole (USP)
5-(4-Thiazolyl)benzimidazole
Tiabendazole (JAN/INN)
4-(1H-benzimidazol-2-yl)thiazole
1yvm
G 491
RPH
NSC-90507
NSC-525040
Tiabendazole [INN]
N1Q45E87DT
DTXSID0021337
CHEBI:45979
2-(4-thiazolyl)-1h-benzoimidazole
NSC90507
4-(1H-benzimidazol-2-yl)-1,3-thiazole
MFCD00005587
CHEMBL625
E233
MLS000053094
DTXCID401337
NSC525040
2-(4-THIAZOLYL)-BENZIMIDAZOLE
NCGC00016410-06
NCGC00016410-13
CAS-148-79-8
SMR000058170
2-(1,3-thiazol-4-yl)-1H-benzoimidazole
2-(1,3-thiazole-4-yl)-1H-benzimidazole
RTU Flowable Fungicide
4-(1H-1,3-benzodiazol-2-yl)-1,3-thiazole
TIABENDAZOLE (MART.)
TIABENDAZOLE [MART.]
Metasol tk 10
Tiabendazolum [INN-Latin]
Thiabendazole [USAN:BAN]
THIABENDAZOLE (USP-RS)
THIABENDAZOLE [USP-RS]
TBZ-6
2-[4-Thiazoly]benzimidazole
Caswell No. 849A
Tiabendazolo
TIABENDAZOLE (EP IMPURITY)
TIABENDAZOLE [EP IMPURITY]
TIABENDAZOLE (EP MONOGRAPH)
TIABENDAZOLE [EP MONOGRAPH]
THIABENDAZOLE (USP MONOGRAPH)
THIABENDAZOLE [USP MONOGRAPH]
Tiabendazol [INN-Spanish, French]
WLN: T56 BM DNJ C-ET5N CSJ
Metasol TK 25
CCRIS 4510
Thiabendazole [ISO]
HSDB 2027
2-Thiazol-4-yl-1H-benzoimidazole
SR-01000000188
EINECS 205-725-8
Thiabendazole-d4 (benzimidazole-4,5,6,7-d4)
NSC 90507
EPA Pesticide Chemical Code 060101
NSC 525040
Thiabendazole [USAN:USP]
BRN 0611403
UNII-N1Q45E87DT
Merfect
AI3-50598
MSD 18
Tiabendazole, INN
Thiabendazole(usan)
Prestwick_813
TECTA
TECTAB
Thiabendazole, 98%
Spectrum_000039
CPD000058170
Thiabendazole 100 microg/mL in Methanol
Opera_ID_336
TBZ (FUNGICIDE)
E-Z-EX Wormer Pellets
Thiabendazole (Standard)
Thiabendazole 10 microg/mL in Acetonitrile
Prestwick0_000524
Prestwick1_000524
Prestwick2_000524
Prestwick3_000524
Spectrum2_001331
Spectrum3_001407
Spectrum4_000354
Spectrum5_001009
THIABENDAZOLE [MI]
TIABENDAZOLE [JAN]
NCIOpen2_005709
THIABENDAZOLE [HSDB]
THIABENDAZOLE [USAN]
Pesticide Code: 060101
SCHEMBL19842
SYNTOL M 100
BSPBio_000507
BSPBio_003054
KBioGR_000787
KBioSS_000399
THIABENDAZOLE [VANDF]
2(4-thiazolyl)-benzimidazole
MLS000069718
BIDD:ER0372
DivK1c_000072
SPECTRUM1500570
TIABENDAZOLE [WHO-DD]
TIABENDAZOLE [WHO-IP]
SPBio_001481
SPBio_002428
E-Z-EX Wormer Mintrate Block
BPBio1_000559
GTPL7304
Thiabendazole, >=99%, powder
HMS500D14
HY-B0263R
KBio1_000072
KBio2_000399
KBio2_002967
KBio2_005535
KBio3_002274
D01AC06
P02CA02
NINDS_000072
HMS1569J09
HMS1921E05
HMS2092M07
HMS2096J09
HMS2230F20
HMS3259E20
HMS3372E11
HMS3655E08
HMS3713J09
Pharmakon1600-01500570
THIABENDAZOLE [GREEN BOOK]
THIABENDAZOLE [ORANGE BOOK]
ALBB-023635
BCP19179
HY-B0263
QXB00720
Tox21_110427
Tox21_202397
Tox21_300970
BDBM50121347
CCG-39633
MSK2522-200M
NSC757347
s1739
STK394289
2-(4'-THIAZOYL)BENZIMIDAZOLE
AKOS000120940
Tox21_110427_1
DB00730
FT38712
NC00593
NSC-757347
SDCCGMLS-0002984.P003
IDI1_000072
USEPA/OPP Pesticide Code: 060101
NCGC00016410-01
NCGC00016410-02
NCGC00016410-03
NCGC00016410-04
NCGC00016410-05
NCGC00016410-07
NCGC00016410-08
NCGC00016410-09
NCGC00016410-10
NCGC00016410-11
NCGC00016410-12
NCGC00016410-14
NCGC00016410-15
NCGC00016410-18
NCGC00016410-21
NCGC00021671-04
NCGC00021671-05
NCGC00021671-06
NCGC00021671-07
NCGC00021671-08
NCGC00021671-09
NCGC00021671-10
NCGC00254873-01
NCGC00259946-01
AC-10139
LS-07459
NCI60_004280
NCI60_042006
SY036760
MLS-0002984.P004
SBI-0051531.P003
DB-042952
AB00052107
NS00007958
SW196947-3
T0830
2-(1,3-Thiazol-4-yl)-1H-benzimidazole #
EN300-20737
Thiabendazole Solution in Methanol, 200ug/mL
Thiabendazole, BAN, BSI, ISO, JMAF, USAN
C07131
D00372
E70385
AB00052107_17
AB00052107_18
Thiabendazole, PESTANAL(R), analytical standard
A808809
Q424986
SR-01000000188-2
SR-01000000188-4
SR-01000000188-5
BRD-K77695569-001-05-2
BRD-K77695569-001-16-9
BRD-K77695569-001-28-4
BRD-K77695569-001-29-2
BRD-K77695569-001-30-0
Z104480436
Thiabendazole, certified reference material, TraceCERT(R)
Thiabendazole, BioReagent, plant cell culture tested, powder
Tiabendazole, European Pharmacopoeia (EP) Reference Standard
Thiabendazole, United States Pharmacopeia (USP) Reference Standard
Thiabendazole, Pharmaceutical Secondary Standard; Certified Reference Material
205-725-8