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Salmeterol

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Identification
Molecular formula
C25H37NO4
CAS number
89365-50-4
IUPAC name
4-[1-hydroxy-2-[(1-methyl-2-phenoxy-ethyl)amino]propyl]phenol
State
State

At room temperature, Salmeterol is in a solid state, predominantly found as a powder.

Melting point (Celsius)
95.00
Melting point (Kelvin)
368.15
Boiling point (Celsius)
443.37
Boiling point (Kelvin)
716.52
General information
Molecular weight
418.57g/mol
Molar mass
418.5340g/mol
Density
0.8620g/cm3
Appearence

Salmeterol is typically found as a white to off-white powder. It is odorless and used in formulations as a fine powder to be blended with carriers for inhalation products.

Comment on solubility

Solubility of 4-[1-hydroxy-2-[(1-methyl-2-phenoxy-ethyl)amino]propyl]phenol

The solubility of the compound 4-[1-hydroxy-2-[(1-methyl-2-phenoxy-ethyl)amino]propyl]phenol (C25H37NO4) is influenced by its complex molecular structure, which includes various functional groups. Understanding its solubility behavior is crucial for its applications in pharmaceuticals and other fields. Here are some key points to consider:

  • Polarity: The presence of the hydroxyl group (-OH) can enhance the solubility of this compound in polar solvents such as water.
  • Hydrophobic Character: The large hydrophobic phenyl and ether components contribute to its solubility in non-polar organic solvents.
  • Amine Interaction: The amino group may engage in hydrogen bonding, further influencing solubility in various solvents.
  • Temperature Dependency: Solubility often increases with temperature, impacting how this compound can be utilized in different concentrations.
  • pH Sensitivity: The solubility can vary depending on the pH of the solution, especially due to the presence of the amino group.

In summary, the solubility of C25H37NO4 can be seen as a balance between its hydrophilic and hydrophobic characteristics. As observed, the compound tends to be more soluble in organic solvents compared to water, but careful tuning of conditions can optimize its solubility for specific applications. This duality makes it an interesting compound to study in the context of drug formulation and delivery.

Interesting facts

Interesting Facts About 4-[1-Hydroxy-2-[(1-Methyl-2-Phenoxy-Ethyl)Amino]Propyl]Phenol

4-[1-Hydroxy-2-[(1-methyl-2-phenoxy-ethyl)amino]propyl]phenol is a fascinating organic compound that showcases the complexity and diversity of modern chemistry. This compound, often studied for its pharmacological properties, exemplifies how slight modifications in molecular structure can lead to significant changes in biological activity.

Applications and Uses

This compound has attracted attention in various fields, particularly in medicinal chemistry and pharmacology, due to its potential applications, such as:

  • Pharmacological Activity: It may exhibit properties that could be beneficial in drug design and discovery, particularly in targeting specific biological mechanisms.
  • Potential Therapeutic Uses: Researchers are investigating its effectiveness in treating conditions related to hormonal regulation and neurotransmission.
  • Structure-Activity Relationship: Its unique structure allows scientists to explore how changes can enhance or inhibit biological responses.

Chemical Significance

The compound's intricate structure provides numerous avenues for research:

  • Hydroxyl Group: The presence of a hydroxyl group allows for strong hydrogen bonding interactions, which can influence solubility and biological activity.
  • Phenoxy Moiety: The phenoxy group may impact how the compound interacts with biological systems, affecting its pharmacokinetics and efficacy.
  • Amine Functionality: The amine group opens pathways for further derivatization, making this compound a versatile scaffold for novel chemical entities.

Research Opportunities

This compound's unique characteristics create exciting opportunities for future research:

  • Synthetic Pathways: Investigating efficient synthetic routes to produce this compound can lead to the development of new methodologies in organic chemistry.
  • Biological Studies: In vivo and in vitro studies are essential to elucidate the biological mechanisms underlying its potential therapeutic effects.
  • Structure Optimization: Exploring various structural modifications can optimize its efficacy and reduce side effects, paving the way for new drugs.

The exploration of 4-[1-hydroxy-2-[(1-methyl-2-phenoxy-ethyl)amino]propyl]phenol not only enriches our understanding of complex organic compounds but also serves as a testament to the profound connection between molecular structure and function in the realm of medicinal chemistry.

Synonyms
isoxsuprine
395-28-8
Dilavase
Duvadilan
Isoxuprine
Vasodilian
4-[1-hydroxy-2-(1-phenoxypropan-2-ylamino)propyl]phenol
1-(p-hydroxyphenyl)-1-propanol
Benzenemethanol, 4-hydroxy-.alpha.-[1-[(1-methyl-2-phenoxyethyl)amino]ethyl]-
Isoxsuprine (INN)
Benzyl alcohol, p-hydroxy-.alpha.-(1-((1-methyl-2-phenoxyethyl)amino)ethyl)-
DTXSID9023178
Dilator (TN)
Duvadilan (Salt/Mix)
Vasodilan (Salt/Mix)
Prestwick0_000068
Prestwick1_000068
Prestwick2_000068
Prestwick3_000068
BSPBio_000255
SCHEMBL181079
SPBio_002176
BPBio1_000281
CHEMBL1197051
CHEBI:91855
NCGC00018295-02
NS00010015
D08092
EN300-18552793
Q1117888
BRD-A74269027-003-03-8
4-{1-hydroxy-2-[(1-phenoxypropan-2-yl)amino]propyl}phenol
4-(1-Hydroxy-2-[(1-methyl-2-phenoxyethyl)amino]propyl)phenol #
4-(1-hydroxy-2-{[1-methyl-2-(phenyloxy)ethyl]amino}propyl)phenol
4-[1-hydroxy-2-[(1-methyl-2-phenoxy-ethyl)amino]propyl]phenol
4-Hydroxy-.alpha.-[1-[(1-methyl-2-phenoxyethyl)amino]ethyl]benzyl alcohol
p-Hydroxy-.alpha.-(1-((1-methyl-2-phenoxyethyl)amino)ethyl)benzyl alcohol
1-(p-Hydroxyphenyl)-2-(1'-methyl-2'-phenoxyethylamino)propanol-2-hydrochloride (Salt/Mix)
erythro-1-(p-Hydroxyphenyl)-2-(.alpha.-methyl-.beta.-phenoxyethylamino)propanol
Benzenemethanol, 4-hydroxy-.alpha.-[1-[(1-methyl-2-phenoxyethyl)amino]ethyl]-, hydrochloride