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Tetrandrine

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Identification
Molecular formula
C38H42N2O6
CAS number
518-34-3
IUPAC name
3,9-dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline-2,10-diol
State
State

Solid: Tetrandrine is a solid at room temperature, typically in the form of crystalline powder. It remains stable under standard room conditions.

Melting point (Celsius)
218.00
Melting point (Kelvin)
491.15
Boiling point (Celsius)
440.00
Boiling point (Kelvin)
713.15
General information
Molecular weight
622.74g/mol
Molar mass
622.6860g/mol
Density
1.3641g/cm3
Appearence

Tetrandrine is typically a crystal-like solid that appears as white to off-white powder. It lacks a distinctive odor and is moderately soluble in water.

Comment on solubility

Solubility of 3,9-dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline-2,10-diol

The solubility of 3,9-dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline-2,10-diol (C38H42N2O6) can be characterized by several key factors:

  • Polarity: The presence of hydroxyl groups (-OH) increases the polarity of the molecule, potentially enhancing its solubility in polar solvents such as water.
  • Functional Groups: The methoxy groups (-OCH3) contribute to molecular interactions, which may influence solubility behavior in organic solvents.
  • Hydrogen Bonding: The ability to form hydrogen bonds can significantly affect solubility. The diol structure suggests good hydrogen bonding potential with water.
  • Solvent Compatibility: This compound may be more soluble in organic solvents like ethanol or methanol due to its large hydrocarbon framework, which may hinder solubility in highly polar environments.

As with many complex organic compounds, predicting solubility can be intricate. Factors such as temperature and solvent pH can further influence solubility. Overall, while solubility studies should be conducted for precise data, the molecular structure indicates:

“A tendency for solubility in polar solvents, with possible increased solubility in ethanol and other less polar organic solvents.”

In conclusion, thorough solubility testing is advised to ascertain the specific behavior of this compound in various environments.

Interesting facts

Interesting Facts about 3,9-Dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline-2,10-diol

This compound, with its complex structure, is a fascinating member of the isoquinoline family. Not only does it feature an intricate arrangement of atoms, but it also displays a variety of significant chemical properties and potential applications in medicinal chemistry. Here are some intriguing aspects of this compound:

  • Isoquinoline Derivative: As a derivative of isoquinoline, this compound shares structural characteristics with many compounds known for their biological activity, suggesting potential pharmacological properties.
  • Functional Groups: The presence of multiple methoxy groups and a diol structure can contribute to its reactivity and interaction in biological systems, making it interesting for synthesis and drug development.
  • Therapeutic Potential: Compounds similar to this one have been researched for their effects in treating various health conditions, including neurological disorders and certain types of cancer, emphasizing the importance of exploring its properties further.
  • Challenges in Synthesis: The complex nature of the molecule suggests that synthesizing it may be a challenging task for chemists, requiring advanced techniques and methodologies.

In conclusion, 3,9-dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline-2,10-diol represents a captivating area of study in organic and medicinal chemistry. Scientists continue to investigate its structural properties in hopes of uncovering new applications and enhancing our understanding of isoquinoline derivatives.

Synonyms
D,L-Stepholidine
16562-14-4
6H-Dibenzo[a,g]quinolizine-2,10-diol, 5,8,13,13a-tetrahydro-3,9-dimethoxy-
3,9-dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline-2,10-diol
CHEMBL595489
DTXSID00274461
Probes1_000256
Probes2_000298
SCHEMBL460434
CHEBI:91837
(12bS)-4,10-dimethoxy-7,8,12b,13-tetrahydro-5H-6-azatetraphene-3,11-diol
BDBM50152837
HSCI1_000061
AKOS030254427
(A+/-)-Berbine-2,10-diol, 3,9-dimethoxy-
Q7611023
BRD-A71203467-001-01-5