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Trimethadione

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Identification
Molecular formula
C6H9NO3
CAS number
127-48-0
IUPAC name
3,5,5-trimethyloxazolidine-2,4-dione
State
State

At room temperature, Trimethadione is in a solid state. It is stable under standard conditions and not hygroscopic, maintaining its dry powdery form.

Melting point (Celsius)
152.00
Melting point (Kelvin)
425.00
Boiling point (Celsius)
275.00
Boiling point (Kelvin)
548.00
General information
Molecular weight
143.15g/mol
Molar mass
143.1470g/mol
Density
1.1955g/cm3
Appearence

Trimethadione appears as a white crystalline powder that can sometimes have a slight odor. It is primarily used in an anhydrous form and often presents very pure crystal formations.

Comment on solubility

Solubility of 3,5,5-Trimethyloxazolidine-2,4-dione

The solubility of 3,5,5-trimethyloxazolidine-2,4-dione (C6H9NO3) is an interesting topic for exploration due to its distinctive structural features. This compound exhibits varied solubility characteristics that depend on the solvent used and conditions such as temperature.

General Solubility Traits

  • Polar solvents: 3,5,5-trimethyloxazolidine-2,4-dione has shown moderate solubility in polar protic solvents like water due to the presence of its nitrogen and oxygen atoms, which can engage in hydrogen bonding.
  • Non-polar solvents: Conversely, it may exhibit lower solubility in non-polar solvents, which is common for compounds with polar functional groups.
  • Temperature effects: Temperature variations can also influence its solubility; generally, an increase in temperature tends to enhance solubility, making it easier for the compound to dissolve.

As a result, one might often encounter scenarios where effective solubility characterization is crucial, particularly in pharmaceutical formulations where the solubility profile can affect bioavailability and efficacy.

Key Takeaways

  • Moderate solubility in polar solvents.
  • Lower solubility in non-polar media.
  • Temperature can significantly impact solubility behavior.

Understanding these solubility aspects provides valuable insights for researchers and practitioners in the field, ensuring proper handling and application of this intriguing compound.

Interesting facts

Interesting Facts About 3,5,5-Trimethyloxazolidine-2,4-dione

3,5,5-trimethyloxazolidine-2,4-dione, commonly known as a cyclic urea, is a compound that plays a significant role in the field of organic chemistry. Here are some captivating details about this intriguing molecule:

  • Versatile Reactivity: This compound is known for its ability to participate in various chemical reactions, making it a valuable intermediate in the synthesis of pharmaceuticals and agrochemicals.
  • Structural Significance: The oxazolidine ring structure introduces unique stereochemical properties, influencing the behavior of the compound in biological systems.
  • Potential Applications: Researchers are exploring the use of 3,5,5-trimethyloxazolidine-2,4-dione as a building block for the synthesis of more complex molecules, notably in the development of drug candidates.

Chemical Characteristics

The presence of the trimethyl group in its structure enhances the compound's lipophilicity, which is pivotal for interactions within biological membranes. This property is often a focus in designing molecules for pharmaceutical use.

Scientific Community Insights

Some chemists remark that compounds like 3,5,5-trimethyloxazolidine-2,4-dione are essential for advancing medicinal chemistry. As one prominent chemist noted, "The quest for new therapeutic agents often begins with the exploration of small cyclic compounds that harbor great potential."

Overall, 3,5,5-trimethyloxazolidine-2,4-dione represents a fascinating area of study within organic synthesis, showcasing how simple structural components can lead to remarkable avenues in research and development.

Synonyms
trimethadione
127-48-0
Tridione
Troxidone
Trimethadion
Trimetadione
Absentol
Epidione
Minoaleviatin
Trimetin
Convenixa
Convexina
Petimalin
Tioxanona
Tridilona
Trimethin
Absetil
Petidion
Petidon
Petilep
Tridion
Trimedal
Edion
Epixal
Ptimal
Tridone
2,4-OXAZOLIDINEDIONE, 3,5,5-TRIMETHYL-
3,5,5-Trimethyloxazolidine-2,4-dione
Trimetadiona
Trimethadionum
Trimethdione
Trimethinum
Trioksal
3,5,5-Trimethyl-1,3-oxazolidine-2,4-dione
Minoaleuiatin
Tredione
Tricione
Trilidona
Trimedone
Triozanona
Tromedone
Epidone
Etydion
Pitmal
3,5,5-Trimethyl-2,4-oxazolidinedione
A 2297
Mino-Aleviatin
3,3,5-Trimethyl-2,4-diketooxazolidine
Trimetadiona [INN-Spanish]
Trimethadionum [INN-Latin]
NSC 15799
Tridione Dulcet
3,5,5-Trojmetylooksazolidyno-2,4-dion
3,5,5,-Trimethyloxazolidine-2,4-dione
UNII-R7GV3H6FQ4
EINECS 204-845-8
R7GV3H6FQ4
NSC-15799
NSC-169503
BRN 0121627
DTXSID9021396
trimethyl-1,3-oxazolidine-2,4-dione
J2.519D
CHEBI:9727
DTXCID801396
3,5,5-TRIMETHYL-OXAZOLIDINE-2,4-DIONE
NSC15799
Trimethadione [USP:INN:BAN:JAN]
NCGC00016383-01
CAS-127-48-0
Trimetadione [DCIT]
Trimetadiona (INN-Spanish)
Trimethadionum (INN-Latin)
2, 3,5,5-trimethyl-
TRIMETHADIONE (MART.)
TRIMETHADIONE [MART.]
TRIMETHADIONE (USP-RS)
TRIMETHADIONE [USP-RS]
Trimethadione (USP:INN:BAN:JAN)
TRIMETHADIONE (EP MONOGRAPH)
TRIMETHADIONE [EP MONOGRAPH]
3,5-Trimethyl-2,4-oxazolidinedione
3,5-Trimethyl-2,4-diketooxazolidine
WLN: T5OVNV EHJ C1 E1 E1
Tridione (TN)
MFCD00047084
3,5,5-Trojmetylooksazolidyno-2,4-dion [Polish]
Mino aleviatin
Prestwick_815
Trimethadione (Standard)
Prestwick0_000515
Prestwick1_000515
Prestwick2_000515
Prestwick3_000515
TRIMETHADIONE [MI]
CHEMBL695
TRIMETHADIONE [INN]
TRIMETHADIONE [JAN]
Trimethadione (JP18/INN)
SCHEMBL28882
BSPBio_000469
TRIMETHADIONE [VANDF]
MLS001076685
SPBio_002390
TRIMETHADIONE [WHO-DD]
TRIMETHADIONE [WHO-IP]
BPBio1_000517
GTPL7316
HY-A0092R
IRYJRGCIQBGHIV-UHFFFAOYSA-
N03AC02
HMS1569H11
HMS2093D10
HMS2096H11
HMS2235E12
HMS3713H11
HMS3886I12
Pharmakon1600-01505466
TRIMETHADIONE [ORANGE BOOK]
AAA12748
HY-A0092
Tox21_110408
Tox21_200231
BDBM50227239
NSC169503
NSC759152
s5567
Trimethadione 1.0 mg/ml in Methanol
TRIMETHADIONUM [WHO-IP LATIN]
AKOS006229172
CCG-213460
DB00347
NSC-759152
NCGC00016383-02
NCGC00016383-03
NCGC00016383-05
NCGC00257785-01
BS-15128
DA-78621
SMR000499583
SBI-0206923.P001
NS00024046
D00392
D84162
EN300-123536
3,5,5-Trimethyl-1,3-oxazolidine-2,4-dione #
Q827916
SR-01000763540
SR-01000763540-2
BRD-K16606819-001-07-7
BRD-K16606819-001-10-1
BRD-K16606819-001-11-9
BRD-K16606819-001-12-7
Z1201618106
3,5,5,-Trimethyloxazolidine-2,4-dione, analytical standard
Trimethadione, European Pharmacopoeia (EP) Reference Standard
InChI=1/C6H9NO3/c1-6(2)4(8)7(3)5(9)10-6/h1-3H3
204-845-8