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Identification
Molecular formula
C15H19Cl2N2O3
CAS number
85069-37-2
IUPAC name
3,5-dichloro-N-[(1-ethylpyrrolidin-2-yl)methyl]-2-hydroxy-6-methoxy-benzamide
State
State

At room temperature, this compound is typically found as a solid due to its high molecular weight and resulting intermolecular interactions. Its crystalline nature grants it a stable form under standard conditions.

Melting point (Celsius)
180.00
Melting point (Kelvin)
453.15
Boiling point (Celsius)
400.00
Boiling point (Kelvin)
673.15
General information
Molecular weight
332.65g/mol
Molar mass
332.6490g/mol
Density
1.4000g/cm3
Appearence

3,5-Dichloro-N-[(1-ethylpyrrolidin-2-yl)methyl]-2-hydroxy-6-methoxy-benzamide typically appears as a white to off-white crystalline powder. As with many organic compounds of its nature, the appearance may vary slightly depending on purity and specific form.

Comment on solubility

Solubility of 3,5-Dichloro-N-[(1-ethylpyrrolidin-2-yl)methyl]-2-hydroxy-6-methoxy-benzamide

The solubility of 3,5-dichloro-N-[(1-ethylpyrrolidin-2-yl)methyl]-2-hydroxy-6-methoxy-benzamide (C15H19Cl2N2O3) is influenced by various factors, particularly its molecular structure and the presence of polar and non-polar functional groups. This compound exhibits characteristics that suggest it may have limited solubility in water, primarily due to:

  • Hydrophobic regions: The hydrocarbon chains and aromatic systems tend to disrupt aqueous interactions.
  • Presence of chloride atoms: The dipole moments created by chlorine may enhance solubility in organic solvents rather than in polar solvents like water.
  • Hydrophilic functional groups: The hydroxyl and methoxy groups could contribute positively to solubility in polar solvents, but their effect may be outweighed by hydrophobic interactions.

In general, this compound is expected to demonstrate:

  1. Higher solubility in organic solvents: Such as ethanol, methanol, or DMSO.
  2. Lower solubility in water: Making it less viable for uses that require aqueous environments.

Researchers might consider utilizing co-solvents or pH adjustments to enhance the solubility, as the interplay between ionic and non-ionic character plays a crucial role in the dissolution process. As a final note, understanding the solubility behavior of this compound is vital for applications in pharmaceuticals and material sciences, as it impacts bioavailability and compound stability.

Interesting facts

Interesting Facts about 3,5-Dichloro-N-[(1-ethylpyrrolidin-2-yl)methyl]-2-hydroxy-6-methoxy-benzamide

This chemical compound is particularly fascinating due to its unique structural features and potential applications in medicinal chemistry. Here are some noteworthy points to consider:

  • Dual Action: The compound features both a dichloro (Cl) and methoxy (OCH3) functional group, which can enhance its biological activity and specificity in target interactions, making it interesting for pharmaceutical research.
  • Biological Relevance: Compounds like these are often studied for their roles in drug development, especially in the field of neuropharmacology. Its pyrrolidine ring can suggest potential effects on the central nervous system.
  • Structure-Activity Relationship (SAR): Understanding how modifications to this compound affect biological activity is a key area of study. The combination of different functional groups can significantly alter the interaction with biological targets.
  • Research Applications: The unique chemical structure of 3,5-dichloro-N-[(1-ethylpyrrolidin-2-yl)methyl]-2-hydroxy-6-methoxy-benzamide makes it a candidate for research in developing novel therapeutics for various conditions.
  • Synthesis Complexity: The synthesis of such a complex molecule often requires multi-step organic synthesis techniques, showcasing the ingenuity and skill in modern chemistry laboratories.

As a chemistry student or scientist, the study of this compound not only deepens your understanding of complex organic structures but also opens avenues in drug development, making this compound a valuable subject for further research and exploration.

In the words of chemist Robert H. Grubbs, "Chemistry is the science of transformation," and compounds like this exemplify that transformative power in a biological context.

Synonyms
3,5-dichloro-N-[(1-ethylpyrrolidin-2-yl)methyl]-2-hydroxy-6-methoxybenzamide
SCHEMBL7472330
DTXSID50861067
3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxy-benzamide(Raclopride)
WAOQONBSWFLFPE-UHFFFAOYSA-N
HMS3370D08
HMS3393C03
BDBM50010637
AKOS040759207
LS-14414
L000503
(-)-N-Ethyl-2-(3,5-dichloro-6-hydroxy-2-methoxybenzamidomethyl)pyrrolidine
3,5-dichloro-N-(1-ethylpyrrolidin-2-ylmethyl)-2 hydroxy-6-methoxybenzamide
(S)-3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxy-benzamide(raclopride)