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Triclosan

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Identification
Molecular formula
C12H7Cl3O2
CAS number
3380-34-5
IUPAC name
3,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxy-phenyl)methyl]phenol
State
State

Triclosan is typically in a solid state at room temperature.

Melting point (Celsius)
56.00
Melting point (Kelvin)
329.15
Boiling point (Celsius)
120.00
Boiling point (Kelvin)
393.15
General information
Molecular weight
289.55g/mol
Molar mass
289.5480g/mol
Density
1.5500g/cm3
Appearence

Triclosan appears as a white to off-white crystalline powder. It is solid at room temperature and has a faint aromatic odor.

Comment on solubility

Solubility of 3,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxy-phenyl)methyl]phenol (C12H7Cl3O2)

The solubility characteristics of 3,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxy-phenyl)methyl]phenol are quite intriguing due to its complex structure. This compound is typically classified as a hydrophobic organic compound, which means:

  • Limited solubility in water: The presence of multiple chlorine substituents and a phenolic –OH group complicates its behavior in aqueous solutions, contributing to its generally low solubility.
  • Higher solubility in organic solvents: The compound exhibits a greater affinity for nonpolar organic substances, often dissolving readily in solvents such as ethanol, acetone, and dichloromethane.

To summarize, its solubility is significantly influenced by:

  • Polar groups (such as hydroxyl)
  • Overall molecular hydrophobicity
  • Temperature and pH of the solvent

Due to these factors, one might often find that solvents play an essential role in facilitating the application and effectiveness of 3,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxy-phenyl)methyl]phenol in various scenarios. Understanding this solubility profile is crucial for chemists when it comes to synthesis and reactivity considerations.

Interesting facts

Interesting Facts about 3,4,6-Trichloro-2-[(2,3,5-trichloro-6-hydroxy-phenyl)methyl]phenol

This compound, known for its complex structure, belongs to a class of chlorinated phenolic compounds. It has garnered interest due to its multifaceted applications and properties. Here are some fascinating aspects:

  • Antimicrobial Properties: This compound exhibits noteworthy antimicrobial efficacy, making it a candidate for use in various disinfectants and preservatives, especially in the formulation of industrial antimicrobial agents.
  • Environmental Impact: The presence of chlorinated components in its structure renders it significant in discussions regarding environmental chemistry, particularly in relation to chlorinated phenols, which can pose toxicological concerns.
  • Pharmaceutical Relevance: Some studies suggest that compounds with similar structures could have potential in pharmaceutical development, providing a basis for research into new drugs with specific biological activities.
  • Pest Control: Compounds like this one have historical applications in pest control, notably in herbicides and insecticides, due to their effectiveness against a wide range of organisms.

It’s fascinating to note that chlorinated phenols, including this compound, can undergo various transformations in the environment, influencing biogeochemical cycles. As a result, understanding their fate is crucial for those studying environmental science and toxicology.

Moreover, as a chemistry student, one can appreciate the intricate balance between utility and safety when handling such compounds. It's a great example of how chemistry can have profound implications on both human health and the environment. As a famous chemist once said, "What we learn from history is that we do not learn from history." Hence, studying compounds like this may offer valuable lessons for sustainable practices in chemistry.

Synonyms
hexachlorophene
70-30-4
Hexachlorofen
pHisoHex
Nabac
Hexachlorophen
Gamophen
Almederm
Septisol
Steraskin
Tersaseptic
Exofene
Fostril
Turgex
Germa-Medica
Hexachlorophane
Gamophene
Hexophene
Acigena
Dermadex
Distodin
Hexabalm
Hexafen
Phisodan
Septofen
Surofene
Fomac
Hexide
Steral
Soy-dome
Surgi-Cen
Surgi-Cin
Cotofilm
Hexascrub
Ritosept
Hexosan
Fesia-sin
Phiso-Scrub
Septi-Soft
Ster-zac
Hexa-Germ
Neosept V
G-Eleven
Hexaclorofeno
Bilevon
E-Z Scrub
Pre-Op
Armohex
Bivelon
Hexachlorophenum
Compound G-11
Nabac 25 ec
Staphene O
Solu-Heks
Esaclorofene
Fascol
G-II
Hexachlorophene [INN]
2,2'-Methylenebis(3,4,6-trichlorophenol)
Scrubteam Surgical Spongebrush
2,2'-methanediylbis(3,4,6-trichlorophenol)
At-17
Rcra waste number U132
Caswell No. 566
Hexaclorofeno [INN-Spanish]
Hexachlorophenum [INN-Latin]
AT-7
3,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxyphenyl)methyl]phenol
Bis(2-hydroxy-3,5,6-trichlorophenyl)methane
Bis(3,5,6-trichloro-2-hydroxyphenyl)methane
NCI-C02653
G-11
CCRIS 331
HSDB 224
2,2',3,3',5,5'-Hexachloro-6,6'-dihydroxydiphenylmethane
2,2'-Dihydroxy-3,3',5,5',6,6'-hexachlorodiphenylmethane
2,2'-Dihydroxy-3,5,6,3',5',6'-hexachlorodiphenylmethane
IWW5FV6NK2
EINECS 200-733-8
NSC 49115
UN2875
Phisohex (TN)
Phenol, 2,2'-methylenebis(3,4,6-trichloro-
Phenol, 2,2'-methylenebis[3,4,6-trichloro-
EPA Pesticide Chemical Code 044901
BRN 2064407
CHEBI:5693
MLS000028433
DTXSID6020690
SMR000058356
Hexachlorophene [USP:INN:BAN]
6,6-Methylenebis(2,4,5-trichlorophenol)
AI3-02372
NSC-49115
Methane, bis(2,3,5-trichloro-6-hydroxyphenyl)
Methane, bis(2,3,5-trichloro-6-hydroxyphenyl)-
6,6'-Methylenebis(2,4,5-trichlorophenol)
HEXACHLOROPHENE [MI]
B 32
Bis-2,3,5-trichlor-6-hydroxyfenylmethan
DTXCID40690
HEXACHLOROPHENE [HSDB]
HEXACHLOROPHENE [IARC]
HEXACHLOROPHENE [VANDF]
MLS002152906
2,2'-Methylenebis[3,4,6-trichlorophenol]
HEXACHLOROPHENE [MART.]
HEXACHLOROPHENE [USP-RS]
HEXACHLOROPHENE [WHO-DD]
Trisophen
Hexaphene-LV
4-06-00-06659 (Beilstein Handbook Reference)
NSC49115
HEXACHLOROPHENE [ORANGE BOOK]
Hilo Flea Powder
MFCD00002171
HEXACHLOROPHENE [USP MONOGRAPH]
UN 2875
Enditch Pet Shampoo
NCGC00091195-04
Inh 1 [PMID: 32284327]
Esaclorofene [DCIT]
Hexachlorofen [Czech]
Hilo Cat Flea Powder
2,4,6-trichlorophenol]
2,5,6-trichlorophenol)
Bis-(2-hydroxy-3,5,6-trichlorophenyl)methane
PRE-OP II
Bis[3,4,6-trichlorophenol], 2,2'-methylene-
Pedigree Dog Shampoo Bar
Hexaclorofeno (INN-Spanish)
Hexachlorophenum (INN-Latin)
HEXACHLOROPHENE (IARC)
HEXACHLOROPHENE (MART.)
HEXACHLOROPHENE (USP-RS)
Hexachlorophene (USP:INN:BAN)
Blockade Anti Bacterial Finish
AT 7
B 32 (VAN)
Bis-2,5-trichlor-6-hydroxyfenylmethan
HEXACHLOROPHENE (USP MONOGRAPH)
CAS-70-30-4
Methane,3,5-trichloro-6-hydroxyphenyl)
B & b Flea Kontroller for Dogs Only
Bis(2-hydroxy-3,6-trichlorophenyl)methane
Bis(3,6-trichloro-2-hydroxyphenyl)methane
Inh 1 (PMID: 32284327)
Phenol,2'-methylenebis[3,4,6-trichloro-
Phenol,2'-methylenebis[3,5,6-trichloro-
WLN: QR BG DG EG F1R BQ CG EG FG
2,3',5,5',6,6'-hexachlorodiphenylmethane
2,5,6,3',5',6'-hexachlorodiphenylmethane
Bis(3,4,6-trichlorophenol), 2,2'-methylene-
SR-01000721924
Brevity Blue Liquid Sanitizing Scouring Cream
2,2-METHYLENE, BIS(3,4,6-TRICHLOROPHENOL)
2,2-METHYLENE, BIS[3,4,6-TRICHLOROPHENOL]
UNII-IWW5FV6NK2
Hexachlorophene [UN2875] [Poison]
Phenol, 2,2'-methylenebis(3,4,6-trichloro)-
RCRA waste no. U132
Brevity Blue Liquid Bacteriostatic Scouring Cream
2,3,3',5,5'-Hexachloro-6,6'-dihydroxydiphenylmethane
Bis-2,3,5-trichloro-6-hydroxyfenylmethan [Czech]
Hexachlorophene (USP/INN)
Germamedica
Fesiasin
Surgicin
Bis-2,3,5-trichloro-6-hydroxyfenylmethan
GEleven
HexapheneLV
SoluHeks
SurgiCen
3,4,6-trichloro-2-((2,3,5-trichloro-6-hydroxyphenyl)methyl)phenol
Thera-Groom Pet Shampoo for Dogs for Veterinary Use Only
2,2'-Methylene bis(3,4,6-trichlorophenol)
Bis(3,5,6-trichloro-2-hydroxyphenyl)-methane
KUC106447N
Compound G11
germa-medica ""mg
KSC-19-051
Spectrum_000867
Opera_ID_504
GERMA-MEDICA "MG
Spectrum2_001105
Spectrum3_000450
Spectrum4_000573
Spectrum5_000792
M0219
CHEMBL496
cid_3598
REGID_for_CID_3598
SCHEMBL15579
BSPBio_002100
KBioGR_001006
KBioSS_001347
MLS001148404
BIDD:ER0608
BIDD:GT0722
DivK1c_000630
G 11 (BACTERICIDE)
HEXACHLOROPHENE [INCI]
SPECTRUM1500328
SPBio_001210
BDBM31712
GTPL11069
HMS501P12
KBio1_000630
KBio2_001347
KBio2_003915
KBio2_006483
KBio3_001320
D08AE01
NSC9887
NINDS_000630
3,3',5,5',6,6'-Hexachloro-2,2'-dihydroxydiphenylmethane
HMS1920D07
HMS2091J13
HMS3259C19
HMS3715P21
KUC112427N
Pharmakon1600-01500328
NSC-9887
Tox21_111099
Tox21_201350
Tox21_302741
3,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxy-phenyl)methyl]phenol
Bis2,3,5trichloro6hydroxyfenylmethan
CCG-39768
NSC757055
s4632
STK377478
AKOS005449243
MSK21000-100M
Tox21_111099_1
CS-3866
DB00756
NC00512
NSC-757055
IDI1_000630
USEPA/OPP Pesticide Code: 044901
NCGC00091195-01
NCGC00091195-02
NCGC00091195-03
NCGC00091195-05
NCGC00091195-06
NCGC00091195-07
NCGC00091195-08
NCGC00091195-09
NCGC00256580-01
NCGC00258902-01
2,2'Methylenebis(3,4,6trichlorophenol)
AC-37557
AS-10068
Bis(2hydroxy3,5,6trichlorophenyl)methane
Bis(3,5,6trichloro2hydroxyphenyl)methane
BP-30177
DA-74102
H3P
HY-12637
KSC-285-117-1
Phenol, 2,2'methylenebis(3,4,6trichloro
Phenol, 2,2'methylenebis(3,5,6trichloro
SBI-0051403.P003
Phenol, 2,2'methylenebis(3,4,6trichloro)
EnViron D Concentrated Phenolic Disinfectant
Methane, bis(2,3,5trichloro6hydroxyphenyl)
NS00009113
bis(3,5,6-trichloro-2-hydroxy phenyl)methane
C08039
D00859
Hexachlorophen Solution in Methanol, 100ug/mL
MLS-0072923.0001
AB00052010_17
EN300-23816802
Hexachlorophene, PESTANAL(R), analytical standard
Q425362
SR-01000721924-2
SR-01000721924-5
SR-01000721924-6
BRD-K99792991-001-02-6
BRD-K99792991-001-18-2
BRD-K99792991-001-34-9
2,2',3,3',5,5'Hexachloro6,6'dihydroxydiphenylmethane
2,2'Dihydroxy3,3',5,5',6,6'hexachlorodiphenylmethane
2,2'Dihydroxy3,5,6,3',5',6'hexachlorodiphenylmethane
TheraGroom Pet Shampoo for Dogs for Veterinary Use Only
2,2-DIHYDROXY-3,3,5,5,6,6-HEXACHLORODIPHENYLMETHANE
Hexachlorophene, United States Pharmacopeia (USP) Reference Standard
139411-96-4
200-733-8