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Cloxacillin

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Identification
Molecular formula
C19H17ClN3NaO5S
CAS number
61-72-3
IUPAC name
3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
State
State

At room temperature, cloxacillin is generally in a solid state, characterized by its crystalline nature. It is often stored in airtight containers to maintain its stability and purity.

Melting point (Celsius)
178.00
Melting point (Kelvin)
451.00
Boiling point (Celsius)
512.00
Boiling point (Kelvin)
785.00
General information
Molecular weight
199.91g/mol
Molar mass
199.9100g/mol
Density
1.3400g/cm3
Appearence

Cloxacillin is a white to slightly yellow crystalline powder, known for its sterile and pure appearance. It is usually supplied in powder form, especially when intended for injectable solutions or for oral suspension formulation.

Comment on solubility

Solubility of 3,3-Dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

The solubility of the compound with the chemical formula C19H17ClN3NaO5S is an important characteristic that influences its behavior in biological systems and practical applications. The solubility of such complex molecules can vary based on several factors, including:

  • Polarity: The presence of polar functional groups often enhances solubility in polar solvents like water.
  • Ionic Character: Its sodium (Na) component suggests that the molecule may exhibit some ionic solubility, potentially making it more soluble in aqueous environments.
  • Hydrophobic Interactions: The hydrophobic phenyl groups may decrease overall solubility in polar solvents, necessitating the evaluation of mixed solvent systems for optimal dissolution.
  • Temperature: Solubility can change with increasing temperature, often leading to increased solubility for many compounds.

As with many other compounds in the same class, it is essential to conduct empirical solubility tests to determine its solubility profile effectively. In practice, compounds of this nature may be found to have varying solubility characteristics, leading scientists to state that:

“The solubility of a compound is key to its pharmacokinetics and therapeutic efficacy.”

Overall, understanding the solubility of 3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid is vital for its application in medicinal chemistry and formulation development.

Interesting facts

Interesting Facts about 3,3-Dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid

This remarkable compound, known for its intricate molecular structure, belongs to the category of thiazolidine derivatives, which are widely studied for their biological activities. Here are some intriguing aspects of this compound:

  • Biological Relevance: The compound has shown potential as an antibiotic and is of particular interest due to its mechanism of action against various bacterial strains, making it a subject of ongoing research in pharmacology.
  • Synthetic Pathways: The synthesis of this compound often involves complex organic reactions, showcasing the beauty and challenge of organic chemistry. It requires precise controlling of reaction conditions to ensure the correct formation of stereochemistry.
  • Structural Diversity: Its unique structure, featuring both bicyclic and thiazolidine frameworks, contributes to diverse chemical properties and activities. The arrangement of functional groups allows for potential modifications that can yield new derivatives with enhanced effectiveness.
  • Research Applications: This compound's potential applications span across medicinal chemistry, where it could lead to the development of new therapeutic agents. The exploration of its derivatives may uncover compounds with improved selectivity and lower toxicity.
  • Cellular Interaction: Studies involving the compound often focus on its interaction with specific biological targets, providing insight into enzyme inhibition and molecular recognition, which are critical for drug design.

As scientists continue to delve deeper into this compound, it embodies the exciting intersection of chemistry and medicine, opening new avenues for therapeutic development. It serves as a testament to the intricacies of compound design and the evolving landscape of pharmaceutical research.

Synonyms
Cillin
7005-30-3
DTXSID20274362
3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Benzopenicillin
Galofak
(5S)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Compocillin G
(Phenylmethyl)penicillin
3,3-Dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Penicillinic acid, benzyl-
1232134-74-5
(Phenylmethyl)penicillinic acid
Phenylacetamidopenicillanic acid
Benzyl-6-aminopenicillinic acid
NSC193396
3,3-dimethyl-7-oxo-6-((2-phenylacetyl)amino)-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid
3,3-dimethyl-7-oxo-6-((phenylacetyl)amino)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
NSC131815
Oprea1_713794
Oprea1_861345
CHEMBL300052
SCHEMBL2109546
DTXCID90225841
DTXSID30859048
NSC11964
NSC-11964
STL453455
AKOS030242685
SB74416
NCI60_000703
NS00001514
WLN: T45 ANV ESTJ CMV1R& F F GVQ
3,3-Dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,3-dimethyl-7-oxo-6-(2-phenylacetamido)-
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]- [2S-(2.alpha.,5.alpha.,6.beta.)]-