Skip to main content

Cloxacillin

ADVERTISEMENT
Identification
Molecular formula
C19H17ClN3O5S
CAS number
61-72-3
IUPAC name
3,3-dimethyl-7-oxo-6-[(2-phenoxyacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
State
State

Solid: Cloxacillin is a crystalline powder at room temperature.

Melting point (Celsius)
178.50
Melting point (Kelvin)
451.50
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
435.87g/mol
Molar mass
0.0000g/mol
Density
1.3300g/cm3
Appearence

Cloxacillin typically appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of 3,3-dimethyl-7-oxo-6-[(2-phenoxyacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

The solubility of 3,3-dimethyl-7-oxo-6-[(2-phenoxyacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid (C19H17ClN3O5S) is influenced by several factors:

  • Polarity: The presence of both hydrophilic (e.g., carboxylic acid, amine) and hydrophobic groups (e.g., phenyl) suggests variable solubility in different solvents.
  • Solvent Type: This compound may exhibit good solubility in polar solvents such as water or methanol, but limited solubility in non-polar solvents like hexane.
  • pH Influence: The carboxylic acid group can ionize, particularly at higher pH levels, potentially increasing solubility in aqueous solutions.

As stated in solubility principles, “like dissolves like.” Thus, the structure of this compound implies that it should perform rather well in polar environments.
However, precise solubility data should be determined experimentally as it can vary significantly with concentration, temperature, and the presence of other solutes.

Interesting facts

Interesting Facts about 3,3-Dimethyl-7-oxo-6-[(2-phenoxyacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

This compound, known for its complex structure, belongs to a class of antibiotics that are particularly noteworthy in the field of medicinal chemistry. Here are some fascinating aspects:

  • Antibacterial Activity: The compound exhibits significant antibacterial properties, making it a candidate for treating various infections caused by resistant bacteria.
  • Unique Structure: The bicyclic structure of this compound makes it an interesting subject for research. Its thiazolidine and azabicyclic characteristics contribute to its biological activity and stability.
  • Synthesis: The synthesis of this compound involves intricate synthetic routes, incorporating various reactions that are a demonstration of the ingenuity in organic chemistry.
  • Research Potential: Scientists are continually exploring its derivatives and analogs to improve efficacy and reduce side effects, enhancing the therapeutic index of related antibiotics.
  • Role in Drug Development: Compounds like this one are pivotal in drug development processes. They inspire modifications that lead to new pharmacological agents with better-suited properties for clinical use.

As we delve deeper into the world of synthetic organic compounds, the study of such unique structures serves as a reminder of the complexities and wonders of chemistry.
“The synthesis of novel compounds is like stepping into a new universe, where each molecule holds untapped potential waiting to be explored.”

Synonyms
Fenoxypen
3,3-Dimethyl-7-oxo-6-[(phenoxyacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Oracilline
Orocillin
3,3-dimethyl-7-oxo-6-[(2-phenoxyacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
3,3-Dimethyl-7-oxo-6-(2-phenoxyacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
PEN V
Oprea1_658892
Oprea1_777083
REGID_for_CID_4731
MLS000703719
SCHEMBL9706988
CHEMBL1711169
CHEBI:94454
DTXSID90859140
BPLBGHOLXOTWMN-UHFFFAOYSA-N
HMS2677L13
HMS3259N06
4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-((phenoxyacetyl)amino)-, (2S-(2.alpha.,5.alpha.,6.beta.))-
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenoxyacetyl)amino]-, [2S-(2.alpha.,5.alpha.,6.beta.)]-
GEC83787
STK177293
AKOS000714928
AKOS022003331
CCG-113795
NC00701
SMR000274084
NS00008310
SR-01000314126
SR-01000314126-1
Q27166319
3,3-dimethyl-7-oxo-6-[(1-oxo-2-phenoxyethyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
3,3-Dimethyl-7-oxo-6-[(phenoxyacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid-, [2S-(2.alpha.,5.alpha.,6.beta.)]-