Cloxacillin | Solubility of Things

Identification

Molecular formula

C₁₉H₁₇ClN₃O₅S

CAS number

61-72-3

IUPAC name

3,3-dimethyl-7-oxo-6-[(2-phenoxyacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

State

At room temperature, Cloxacillin is in the form of a crystalline solid. It is generally provided as a sodium salt for medicinal uses.

Melting point (Celsius)

174.50

Melting point (Kelvin)

447.60

Boiling point (Celsius)

0.00

Boiling point (Kelvin)

0.00

General information

Molecular weight

435.88g/mol

Molar mass

435.8740g/mol

Density

1.3600g/cm³

Appearence

Cloxacillin appears as a fine, white to off-white crystalline powder. It is typically odorless or may have a faint characteristic odor. The compound is soluble in methanol and ethanol, slightly soluble in water, and practically insoluble in hydrocarbon solvents.

Comment on solubility

Solubility of 3,3-dimethyl-7-oxo-6-[(2-phenoxyacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

The solubility of the compound 3,3-dimethyl-7-oxo-6-[(2-phenoxyacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate (C₁₉H₁₇ClN₃O₅S) can be assessed through various factors that affect its interaction with solvents. Understanding its solubility is crucial for potential applications, including medicinal formulations and chemical reactions. Here are some important aspects to consider:

Polarity: The presence of polar functional groups such as amino and carboxylate can enhance solubility in polar solvents like water.
Hydrophobicity: The bulky phenoxyacetyl group may introduce hydrophobic characteristics, potentially limiting water solubility.
pH Dependence: The solubility may vary with pH, particularly due to the presence of the carboxylate ion which can become ionized in basic conditions, thus affecting its overall solubility.
Temperature Influence: As with many organic compounds, increasing temperature may improve solubility due to enhanced molecular motion and interaction between solute and solvent.

In summary, while this compound has the potential for solubility in certain environments, it is essential to consider both the polar and non-polar characteristics that derive from its unique structure. Thus, the solubility behavior might be optimized by tuning the conditions employed in its application.

Interesting facts

Interesting Facts about 3,3-Dimethyl-7-oxo-6-[(2-phenoxyacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

This compound is a fascinating member of a class of chemicals known for their biological activity. Here are some intriguing details:

Structural Complexity: The compound features a unique bicyclic structure, which contributes to its interesting chemical behavior. Bicyclic compounds often exhibit diverse reactivity due to their fused ring systems.
Functional Groups: The presence of various functional groups such as the thiazolidine ring and a carboxylate group plays a crucial role in its biological properties. These functional groups can enhance the interaction of the compound with biological targets.
Biological Applications: Compounds of this type may have potential relevance in pharmaceuticals. They can act as enzyme inhibitors, which can be useful in treating conditions related to overactive enzymes, such as certain cancers or bacterial infections.
Phenoxyacetyl Moiety: The phenoxyacetyl group in its structure suggests that this compound could also possess unique pharmacological activities. It can potentially modify the lipophilicity and stability of the compound, influencing its absorption and distribution in biological systems.
Synthetic Pathway: The synthesis of such complex organic molecules typically involves multiple steps including the formation of rings, side-chain modifications, and precise control over stereochemistry, which are crucial for ensuring the desired biological activity.
Research Potential: Given its complex structure and possible biological effects, this compound warrants further investigation. Scientists might explore various analogs to optimize activity and understand its mechanism of action further.

Overall, compounds like 3,3-dimethyl-7-oxo-6-[(2-phenoxyacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate offer extensive opportunities for research and development in the field of medicinal chemistry.