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Cloxacillin

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Identification
Molecular formula
C19H17ClN3NaO5S
CAS number
61-72-3
IUPAC name
3,3-dimethyl-7-oxo-6-[[2-[(2-oxoimidazolidine-1-carbonyl)amino]-2-phenyl-acetyl]amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
State
State

Solid at room temperature.

Melting point (Celsius)
185.00
Melting point (Kelvin)
458.15
Boiling point (Celsius)
274.00
Boiling point (Kelvin)
547.15
General information
Molecular weight
476.88g/mol
Molar mass
476.8800g/mol
Density
1.3300g/cm3
Appearence

Cloxacillin sodium occurs as a white to off-white, hygroscopic powder. It usually forms crystals.

Comment on solubility

Solubility of 3,3-dimethyl-7-oxo-6-[[2-[(2-oxoimidazolidine-1-carbonyl)amino]-2-phenyl-acetyl]amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

The solubility of 3,3-dimethyl-7-oxo-6-[[2-[(2-oxoimidazolidine-1-carbonyl)amino]-2-phenyl-acetyl]amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid (C19H17ClN3NaO5S) is influenced by several factors that need to be thoroughly examined:

  • Polarity: The presence of polar functional groups, such as carboxylic acid in the compound, suggests potential solubility in polar solvents like water.
  • Ionic Characteristics: The sodium (Na) in the formula implies that the compound may possess ionic characteristics, potentially enhancing solubility in aqueous solutions.
  • Molecular Weight: With a relatively high molecular weight, solubility could be limited in less polar solvents, such as organic solvents.

Despite these attributes, the compound might demonstrate varying solubility behavior due to the complex structure encompassing multiple functional groups. It is particularly notable that:

  1. Solubility can be dependent on pH: The carboxylic acid group might dissociate at high pH, improving solubility.
  2. Interactions with co-solvents may also alter solubility characteristics.
  3. Temperature plays a crucial role; as temperature increases, solubility in most solvents typically increases.

Overall, while the complex nature of this compound suggests that it may not dissolve easily in all solvents, it does hold potential for solubility in specific conditions where polarity and ionic effects come into play. Understanding these factors is essential for predicting and manipulating the solubility of this intriguing compound.

Interesting facts

Interesting Facts about 3,3-Dimethyl-7-oxo-6-[[2-[(2-oxoimidazolidine-1-carbonyl)amino]-2-phenyl-acetyl]amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

This compound, often recognized for its complexity, is a fascinating example of modern medicinal chemistry. Its intricate structure showcases the marriage of various functional groups that contribute to its unique properties and potential applications in pharmacology.

Key Features

  • Synthetic Versatility: With multiple reactive sites, the compound can serve as an intermediate in the synthesis of various pharmaceuticals, allowing for the diversity of drug development.
  • Biological Activity: Compounds of this nature often exhibit significant biological activity, making them of particular interest in drug discovery. Researchers are keenly exploring its potential for treating diseases, especially within the therapeutic domain.
  • Structural Complexity: The bicyclic structure enhances its interaction with biological targets, leading to improved efficacy and selectivity in biological systems.

Furthermore, the presence of the thioether and imidazolidine moieties introduces unique reactivity patterns. As researchers delve into the study of such compounds, they often quote the importance of exploring the structure-activity relationship (SAR). This helps to unravel the connection between the chemical structure and its biological function, a crucial aspect of drug design.

In summary, 3,3-dimethyl-7-oxo-6-[[2-[(2-oxoimidazolidine-1-carbonyl)amino]-2-phenyl-acetyl]amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid is not just a chemical compound; it is a gateway to understanding the vast and intricate world of medicinal chemistry and the endless possibilities that lie within compound synthesis and application.

Synonyms
3,3-dimethyl-7-oxo-6-{[{[(2-oxoimidazolidin-1-yl)carbonyl]amino}(phenyl)acetyl]amino}-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
MLS006011456
CHEMBL4747314
DTXSID20860542
BCP12666
CCG-16574
STK177243
AKOS000715136
AKOS021990221
SMR004703258
Azlocilina; Azlocilline; Azlocillinum;Bay e 6905;Bay-e 6905;Baye 6905
3,3-dimethyl-7-oxo-6-{[{[(2-oxo-1-imidazolidinyl)carbonyl]amino}(phenyl)acetyl]amino}-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
3,3-Dimethyl-7-oxo-6-{2-[(2-oxoimidazolidine-1-carbonyl)amino](phenyl)acetamido}-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
3,3-DIMETHYL-7-OXO-6-{2-[(2-OXOIMIDAZOLIDINE-1-CARBONYL)AMINO]-2-PHENYLACETAMIDO}-4-THIA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID