Skip to main content

Cloxacillin

ADVERTISEMENT
Identification
Molecular formula
C19H17ClN3NaO5S
CAS number
61-72-3
IUPAC name
3,3-dimethyl-6-[(5-methyl-3-phenyl-isoxazole-4-carbonyl)amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
State
State

Cloxacillin is typically found in its sodium salt form, and in this state, it appears as a solid at room temperature. It is formulated into capsules, tablets, or injectable forms for medical use.

Melting point (Celsius)
178.50
Melting point (Kelvin)
451.60
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
435.91g/mol
Molar mass
435.9050g/mol
Density
1.3300g/cm3
Appearence

Cloxacillin typically appears as a white to off-white crystalline powder. It is often supplied as its sodium salt for better solubility in water.

Comment on solubility

Solubility Overview

The solubility of the compound 3,3-dimethyl-6-[(5-methyl-3-phenyl-isoxazole-4-carbonyl)amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid (C19H17ClN3NaO5S) is influenced by its complex structure and the functional groups present. Solubility is a vital property that dictates the compound's interactions in various environments. Here are some key points to consider:

Factors Affecting Solubility:

  • Polarity: The presence of polar functional groups can enhance solubility in polar solvents.
  • Ionic components: The sodium ion (Na+) can facilitate solubility in water due to its ability to interact with water molecules.
  • Hydrophobic regions: The phenyl group contributes to hydrophobic interactions, possibly reducing solubility in polar solvents.

Given the presence of both ionic and hydrophobic characteristics, this compound may exhibit limited solubility in aqueous solutions while potentially being more soluble in organic solvents. Generally, compounds with complex bicyclic structures and multiple functional groups can show varied solubility and require specific environmental conditions for optimal dissolution.

General Observations:

In practical terms, it can be expected that:

  • The compound is likely soluble in organic solvents such as dimethyl sulfoxide (DMSO) and ethanol.
  • Its solubility in water may be moderate to low, influenced heavily by pH and temperature.
  • Utilizing additives or changing solvent conditions may enhance its solubility profile.

Thus, understanding the solubility of this compound is crucial for applications in pharmaceutical formulations and chemical reactions, where the compound's behavior in different solvents must be optimized for efficacy.

Interesting facts

Interesting Facts about 3,3-Dimethyl-6-[(5-methyl-3-phenyl-isoxazole-4-carbonyl)amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

This compound, with its intricate molecular structure, boasts a variety of fascinating characteristics that make it a point of study in the field of chemistry. Here are some notable aspects:

  • Complex Structure: The compound features a bicyclic structure that incorporates a thiazole ring and an isoxazole moiety, highlighting a blend of both organic and heterocyclic chemistry.
  • Biological Activity: Compounds of this class have been investigated for their potential biological activities, which may include anti-inflammatory and antimicrobial properties, making them of interest in medicinal chemistry.
  • Drug Development: Compounds similar to this one serve as templates in the design of novel pharmaceuticals. Their unique structure can offer enhanced efficacy or reduced side effects compared to existing drugs.
  • Synthetic Pathways: The synthesis of such compounds often involves multiple steps and can require advanced techniques like cyclization reactions and amide bond formation, fascinating processes for chemists.
  • Importance of Substitution: The inclusion of different substituents, such as the phenyl group and various carbonyl functionalities, allows for extensive customization of properties that can enhance solubility or biological activity.

As noted by recent studies, "the exploration of structures such as 3,3-dimethyl-6-[(5-methyl-3-phenyl-isoxazole-4-carbonyl)amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid can pave the way for discovering new therapeutic agents." The diversity in its structure makes it a candidate for various pharmacological investigations, driving interest among scientists in both pharmaceutical and academic settings.

In summary, this compound encapsulates a world of possibilities in medicinal chemistry and organic synthesis, wherever its complex structure can lead to groundbreaking developments.

Synonyms
3,3-dimethyl-6-[(5-methyl-3-phenyl-1,2-oxazole-4-carbonyl)amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
3,3-dimethyl-6-[[(5-methyl-3-phenyl-4-isoxazolyl)-oxomethyl]amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
MPI-penicillin; MPi-PC
Oprea1_168564
Oprea1_662776
CHEMBL3305959
SCHEMBL14126543
CHEBI:94315
DTXSID70859062
BCP24142
AKOS000641644
SR-01000316163
SR-01000316163-1
BRD-A03044413-236-01-3
Q27166135