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Phenolphthalein

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Identification
Molecular formula
C20H14O4
CAS number
77-09-8
IUPAC name
3,3-bis(4-hydroxyphenyl)isobenzofuran-1-one
State
State

Phenolphthalein is a solid at room temperature, typically seen as a crystalline powder.

Melting point (Celsius)
258.00
Melting point (Kelvin)
531.00
Boiling point (Celsius)
500.00
Boiling point (Kelvin)
773.00
General information
Molecular weight
318.32g/mol
Molar mass
318.3190g/mol
Density
1.2770g/cm3
Appearence

Phenolphthalein appears as a yellowish-white to pale orange, crystalline powder. It is often used in laboratories due to its distinctive pink color transition in basic solutions, making it a popular pH indicator.

Comment on solubility

Solubility of 3,3-bis(4-hydroxyphenyl)isobenzofuran-1-one (C20H14O4)

The solubility characteristics of 3,3-bis(4-hydroxyphenyl)isobenzofuran-1-one, a compound with a fairly complex structure, can exhibit interesting behavior in various solvents. As an organic compound which contains both aromatic and hydroxyl functional groups, its solubility can be influenced by several factors:

  • Hydroxyl Groups: The presence of hydroxyl (-OH) groups often enhances solubility in polar solvents such as water, due to hydrogen bonding.
  • Aromatic Nature: The aromatic rings may make the compound less soluble in water but more soluble in organic solvents like ethanol or acetone.
  • Steric Factors: The spatial arrangement of the molecule could affect how well it interacts with solvent molecules.

In general, compounds with a significant number of hydroxyl groups tend to "like" polar solvents. Therefore, while 3,3-bis(4-hydroxyphenyl)isobenzofuran-1-one may show some solubility in water, it could be more effectively dissolved in:

  1. Ethanol
  2. Dimethyl sulfoxide (DMSO)
  3. Acetone

It's important to note that the exact solubility might vary widely based on concentration and temperature. Testing the solubility in various solvents can provide valuable insights and help in selecting the appropriate solvent for applications like synthesis or purification.

In summary, while the solubility of C20H14O4 holds potential in both polar and non-polar environments, the interplay of functional groups and solvent types ultimately dictates its behavior. This complex relationship makes the study of solubility in this compound particularly fascinating.

Interesting facts

Interesting Facts about 3,3-bis(4-hydroxyphenyl)isobenzofuran-1-one

3,3-bis(4-hydroxyphenyl)isobenzofuran-1-one, often simply referred to as a derivative of isobenzofuran, exhibits a fascinating blend of chemical properties that make it a subject of study in various fields, including materials science and medicinal chemistry. Here are some key highlights:

  • Structural Diversity: This compound features a unique structure that contributes to its intriguing reactivity and potential applications. The presence of both the isobenzofuran and hydroxyphenyl groups creates possibilities for strong intermolecular interactions.

  • Antioxidant Properties: The hydroxyphenyl groups are known for their antioxidant capabilities, which means this compound could potentially combat oxidative stress in biological systems. This makes it a candidate for further exploration in pharmaceuticals.

  • Material Applications: Thanks to its distinct molecular structure, it has potential uses in advanced polymers and materials, highlighting its significance in the development of new, high-performance materials.

  • Esthetic Considerations: Compounds like this one often possess rich coloration and are of interest in dye chemistry, adding visual appeal to materials and products.

  • Research Applications: Scientists are actively investigating this compound for its potential role in drug development and as an intermediary in organic synthesis, demonstrating its versatility in the lab.

In summary, the compound 3,3-bis(4-hydroxyphenyl)isobenzofuran-1-one is not just interesting for its chemical structure but also for its multiple applications across various scientific disciplines. Its antioxidant properties coupled with material science applications keep it firmly in the spotlight for ongoing research.

Synonyms
phenolphthalein
77-09-8
Phthalimetten
Euchessina
Phthalin
Espotabs
Phenolax
Purgophen
Koprol
Laxogen
Trilax
Purga
Spulmako-lax
Purgen
Phenolphtaleine
Medilax
Colax
Laxin
FemiLax
Dihydroxyphthalophenone
3,3-Bis(4-hydroxyphenyl)phthalide
3,3-Bis(4-hydroxyphenyl)-1(3H)-isobenzofuranone
Fenolftalein
Fenolftaleina
Alophen
1(3H)-Isobenzofuranone, 3,3-bis(4-hydroxyphenyl)-
3,3-Bis(p-hydroxyphenyl)phthalide
Phillips Gelcaps
Phenophthalein
3,3-Bis(4-hydroxyphenyl)isobenzofuran-1(3H)-one
NCI-C55798
Phenolphthaleinum
3,3-bis(4-hydroxyphenyl)-2-benzofuran-1-one
alpha-Di(p-hydroxyphenyl)phthalide
Phenolphthalein,white
Feen-A-Mint Laxative Mints
3,3-Bis(4-hydroxyphenyl)-2-benzofuran-1(3H)-one
NSC 10464
CCRIS 6266
Phthalide 3,3,-bis(p-hydroxyphenyl)-
DTXSID0021125
HSDB 4161
EINECS 201-004-7
UNII-6QK969R2IF
MFCD00005913
component of Agoral
3,3-bis(4-hydroxyphenyl)-1,3-dihydro-2-benzofuran-1-one
BRN 0284423
6QK969R2IF
Yellow phenolphthalein
CHEBI:34914
AI3-09081
NSC-10464
PHENOLPHTHALEIN, WHITE
CHEMBL63857
MLS000069592
DTXCID901125
Correctol
EC 201-004-7
5-18-04-00188 (Beilstein Handbook Reference)
NSC10464
alpha-(p-Hydroxyphenyl)-alpha-(4-oxo-2,5-cyclohexadien-1-ylidene)-o-toluic acid
Evac-Q-Kwik
Evac-Q-Kit
Evac-U-Gen
component of Correctol
Phenolphthalein (INN)
NCGC00018200-07
SMR000059015
Agoral
Fenolftalein [Czech]
PHENOLPHTHALEIN [INN]
PHENOLPHTHALEIN (IARC)
PHENOLPHTHALEIN [IARC]
Fenolftaleina [INN-Spanish]
PHENOLPHTHALEIN (MART.)
PHENOLPHTHALEIN [MART.]
Phenolphtaleine [INN-French]
Phenolphthaleinum [INN-Latin]
Phthalide 3,-bis(p-hydroxyphenyl)-
PHENOLPHTHALEIN (EP MONOGRAPH)
PHENOLPHTHALEIN [EP MONOGRAPH]
CAS-77-09-8
WLN: T56 BVO DHJ D- D-/R DQ 2
Phenolphthalein (0.04% Solution in Ethanol)
1(3H)-Isobenzofuranone,3-bis(4-hydroxyphenyl)-
phenolphtalein
Phenolphthalein [USP:INN:BAN]
FGT
white phenolphthalein
Doxan (Salt/Mix)
Agoral (Salt/Mix)
Modane (TN)
Phenolphthalein White
Phenolphthalein,(S)
Laxcaps (Salt/Mix)
Phenolphthalein,yellow
PHENPOLPHTHALEIN
Phenolphthalein solution
Spectrum_001077
Opera_ID_1337
Spectrum2_001279
Spectrum3_000888
Spectrum4_000982
Spectrum5_001268
Modane Plus (Salt/Mix)
3,3-bis(4-hydroxyphenyl)isobenzofuran-1-one
Phenolphthalein ACS reagent
Phenolphthalein solution R1
cid_4764
PHENOLPHTHALEIN [MI]
Phenolphthalein, ACS reagent
SCHEMBL27670
BSPBio_002518
KBioGR_001383
KBioSS_001557
Phenolphthalein, pH indicator
MLS001148397
BIDD:ER0202
DivK1c_000929
PHENOLPHTHALEIN [HSDB]
SPECTRUM1500480
Phenolphthalein Paper, DAB 6
SPBio_001278
PHENOLPHTHALEIN [VANDF]
3,3-bis(4-hydroxyphenyl)-3-hydroisobenzofuran-1-one
PHENPOLPHTHALEIN [VANDF]
PHENOLPHTHALEIN [WHO-DD]
BCBcMAP01_000174
HMS502O11
KBio1_000929
KBio2_001557
KBio2_004125
KBio2_006693
KBio3_001776
A06AB04
NINDS_000929
BP_31
HMS1920H04
HMS2091P06
HMS2236I09
HMS3374P06
Pharmakon1600-01500480
component of Correctol (Salt/Mix)
HY-D0211
Phenolphthalein, p.a., ACS reagent
Tox21_110838
Tox21_202219
Tox21_300282
BBL002030
BDBM50077844
CCG-39112
NSC215214
NSC757271
PHENOLPHTHALEIN,WHITE [VANDF]
s5395
STK029876
AKOS000493033
Tox21_110838_1
CS-8152
DB04824
NSC-215214
NSC-757271
IDI1_000929
SMP1_000235
NCGC00018200-01
NCGC00018200-02
NCGC00018200-03
NCGC00018200-04
NCGC00018200-05
NCGC00018200-06
NCGC00018200-08
NCGC00018200-09
NCGC00018200-10
NCGC00018200-12
NCGC00023694-03
NCGC00023694-04
NCGC00023694-05
NCGC00023694-06
NCGC00023694-07
NCGC00254039-01
NCGC00259768-01
AC-14431
BP-30100
VS-01000
2,2-BIS(P-HYDROXYPHENYL)PHTHALIDE
SBI-0051481.P003
1ST000813
EU-0082600
NS00008592
P0094
P0700
P0701
P0702
3,3-bis(4-hydroxyphenyl)-2-benzofuran-1-on
EN300-92962
Phenolphthalein, SAJ first grade, >=97.0%
.alpha., .alpha.-Di(p-hydroxyphenyl)phthalide
3,3-bis (4-hydroxyphenyl)-2-benzofuran-1-on
D05456
H12020
Phenolphthalein, JIS special grade, >=98.0%
AB00052070_15
Q187921
SR-01000000112
3,3-Bis-(4-hydroxyphenyl)-1-(3H)-isobenzofuranon
SR-01000000112-2
3,3-Bis(4-hydroxyphenyl)-2-benzofuran-1(3H)-one #
3,3-Bis-(4-hydroxy-phenyl)-3H-isobenzofuran-1-one
BRD-K19227686-001-02-0
BRD-K19227686-001-12-9
BRD-K19227686-001-18-6
Z57233591
F0921-4309
Phenolphthalein (263 degrees C) Melting Point Standard
Phenolphthalein, United States Pharmacopeia (USP) Reference Standard
ALPHA-(P-HYDROXYPHENYL)-ALPHA-(4-OXO-2,5-CYCLOHEXADIEN-1-YLIDINE)-O-TOLUIC ACID
201-004-7
201-384-4
InChI=1/C20H14O4/c21-15-9-5-13(6-10-15)20(14-7-11-16(22)12-8-14)18-4-2-1-3-17(18)19(23)24-20/h1-12,21-22
Phenolphthalein;2-[Bis(4-hydroxyphenyl)methyl]benzoic acid;3,3-Bis(4-hydroxyphenyl)phthalide