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Nicotine

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Identification
Molecular formula
C10H14N2
CAS number
54-11-5
IUPAC name
3-pyrrolidin-2-ylpyridine
State
State

Nicotine is typically found in a liquid state at room temperature. It is highly volatile and can form a colorless or slightly yellow solution when dissolved in water.

Melting point (Celsius)
-79.00
Melting point (Kelvin)
194.15
Boiling point (Celsius)
247.00
Boiling point (Kelvin)
520.15
General information
Molecular weight
162.24g/mol
Molar mass
162.2370g/mol
Density
1.0100g/cm3
Appearence

Nicotine is a colorless to pale yellow, volatile, hygroscopic liquid with a characteristic tobacco odor. It is extremely hygroscopic, capable of absorbing moisture from the air when exposed.

Comment on solubility

Solubility of 3-pyrrolidin-2-ylpyridine (C10H14N2)

3-pyrrolidin-2-ylpyridine, a compound with an intriguing structure, presents unique solubility characteristics. Understanding its solubility is essential in various applications, particularly in pharmaceuticals and organic chemistry. Here are some key points regarding its solubility:

  • Polar Characteristics: The presence of nitrogen atoms in the structure typically indicates some degree of polarity, which can enhance solubility in polar solvents such as water and alcohol.
  • Hydrophobic vs. Hydrophilic: The pyridine ring may impart some hydrophobic traits, while the pyrrolidine group contributes hydrophilic characteristics, suggesting variable solubility patterns.
  • Common Solvents: This compound is generally soluble in organic solvents like ethanol, dichloromethane, and acetonitrile, which are often used to dissolve similar nitrogen-containing heterocycles.
  • Thermodynamic Factors: Solubility can also depend on temperature and pressure, and it may exhibit different solubility levels under varying experimental conditions.

In summary, the solubility of 3-pyrrolidin-2-ylpyridine is influenced by its unique molecular structure, making it soluble in several organic solvents while demonstrating a balance between hydrophilic and hydrophobic properties.

Interesting facts

Interesting Facts about 3-Pyrrolidin-2-ylpyridine

3-Pyrrolidin-2-ylpyridine is a fascinating organic compound that belongs to the family of pyridine derivatives. This compound has garnered attention in both academic research and pharmaceutical applications due to its unique structure and properties. Here are some intriguing aspects:

  • Pyridine Core: The pyridine ring structure is a six-membered aromatic ring containing a nitrogen atom. This feature enhances the compound's electron-deficient nature, making it a good candidate for various chemical reactions.
  • Biological Activity: Compounds similar to 3-pyrrolidin-2-ylpyridine have been studied for their potential biological activities. They may exhibit antimicrobial, anti-inflammatory, or antitumor properties, significantly contributing to medicinal chemistry research.
  • Synthetic Applications: This compound can be synthesized via various methods, including catalytic reactions and multi-step synthesis pathways. Its ability to act as a base makes it valuable in organic synthesis, where it can facilitate nucleophilic substitutions and addition reactions.
  • Structural Features: The presence of the pyrrolidine group not only influences the compound's reactivity but also its sterics and electronics. This unique combination can lead to interesting interactions with biological targets, offering a great platform for drug development.
  • Potential in Therapeutics: Given its structural diversity, 3-pyrrolidin-2-ylpyridine is being explored in the context of designing new therapies for various diseases, particularly in neurology, where compounds affecting neurotransmitter systems are of interest.

In conclusion, 3-Pyrrolidin-2-ylpyridine exemplifies the exquisite complexity found in organic chemistry, highlighting how subtle changes in molecular structure can lead to significant variances in properties and potential applications. As research progresses, this compound may unravel new potentials in therapeutic development.

Synonyms
3-(pyrrolidin-2-yl)pyridine
5746-86-1
nornicotine
3-(2-Pyrrolidinyl)pyridine
(R,S)-Nornicotine
3-pyrrolidin-2-ylpyridine
(+/-)-Nornicotine
3-pyrrolidin-2-yl-pyridine
(+-)-Nornicotine
DL-NORNICOTINE
(+-)-1'-Demethylnicotine
MFCD00016913
2-(3-Pyridyl)pyrrolidine
3-(2-Pyrrolidyl)pyridine
(+-)-3-(2-Pyrrolidinyl)pyridine
CHEMBL1132
( inverted exclamation markA)-Nornicotine
(S)-3-Pyrrolidin-2-yl-pyridine
13450-58-3
3-[(2RS)-Pyrrolidin-2-yl]pyridine ((RS)-Nornicotine)
SMR000449277
(R,S)-Nornicotine (1.0 mg/mL in Methanol)
(S)-2-(3-Pyridyl)pyrrolidine
2-(Pyridin-3-yl)pyrrolidine
dl-Norcitine
MFCD09257346
(RS)-nornicotine
Nicotine, 1'-demethyl-, (+-)-
DL-2-(3-PYRIDYL)PYRROLIDINE
Nornicotine, 97%
.beta.-dl-Nornicotine
Pyridine, 3-(2-pyrrolidinyl)-, (+-)-
(.+/-.)-Nornicotine
MLS000758240
MLS001424032
(+-)-1'-demethyl-Nicotine
SCHEMBL158145
3-(pyrolidin-2-yl)-pyridine
SCHEMBL13090363
(.+/-.)-1'-Demethylnicotine
DTXSID50862034
(R)-3-(2-Pyrrolidinyl)pyridine
(R)-3-Pyrrolidin-2-yl-pyridine
3-Pyrrolidin-2-ylpyridine, 95%
GLXC-19132
HMS2051O11
HMS2232N03
HMS3372K03
HMS3393O11
2-(3-PYRIDINYL)PYRROLIDINE
AR1067
BDBM50023328
STL139255
(+/-)-3-(pyrrolidin-2-yl)pyridine
AKOS001428655
AKOS016050380
AB01223
CCG-100790
CS-W002112
FN26467
GF-0112
NC00040
SB37344
SB37747
NCGC00163364-01
Nicotine, 1'-demethyl-, (.+/-.)-
1ST14014
AC-10074
SY023448
SY245637
DB-021745
NS00098483
EN300-23749
(+/-)-Nornicotine, >=98% (TLC), liquid
C06524
P67210
Pyridine, 3-(2-pyrrolidinyl)-, (.+/-.)-
(S)-Nornicotine;(s)-(2-[3-Pyridyl]pyrrolidine)
Q907939
2-[3-Pyridyl]pyrrolidine;(+/-)-1'-Demethylnicotine
BRD-A24543851-001-05-7
Z164706372
(+/-)-Nornicotine-d4, 100 mug/mL in methanol, ampule of 1 mL, certified reference material
637-353-0