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Pyriproxyfen

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Identification
Molecular formula
C20H19NO3
CAS number
95737-68-1
IUPAC name
3-pyridylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate
State
State

At room temperature, pyriproxyfen is typically a solid, appearing as an off-white crystalline powder. It is used predominantly in the form of solutions or suspensions for pest control purposes.

Melting point (Celsius)
46.80
Melting point (Kelvin)
319.95
Boiling point (Celsius)
450.50
Boiling point (Kelvin)
723.70
General information
Molecular weight
321.37g/mol
Molar mass
321.3740g/mol
Density
1.3000g/cm3
Appearence

Pyriproxyfen is a pale yellow amorphous solid. It is typically available in various formulated products, such as emulsifiable concentrates or granules for ease of application.

Comment on solubility

Solubility of 3-pyridylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate

The solubility of the compound 3-pyridylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate, with the chemical formula C20H19NO3, can be quite intricate due to its extensive molecular structure. Such compounds often exhibit varied solubility characteristics depending on the following factors:

  • Polarity: The presence of polar functional groups such as amides and pyridines may increase its solubility in polar solvents like water or methanol.
  • Molecular Interactions: The ability to form hydrogen bonds can enhance solubility, particularly in solvents capable of donating or accepting hydrogen bonds.
  • Temperature Effects: Solubility is generally temperature-dependent; heating may improve the dissolution of solid compounds.
  • pH Levels: The ionization state of the compound can shift with pH changes, impacting its solubility profiles.

As a rule of thumb, it's often stated that "like dissolves like." Therefore, exploring various solvents that mimic the structural characteristics of 3-pyridylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate can yield better solubility outcomes. Testing in both polar and non-polar solvents will provide a clearer understanding of its solubility behavior.

Interesting facts

Interesting Facts about 3-Pyridylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate

3-Pyridylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate is a fascinating compound known for its potential applications in medicinal chemistry. Here are several noteworthy aspects:

  • Medicinal Chemistry: This compound features a pyridine ring, which is significant in drug discovery due to its ability to interact with biological targets.
  • Anticancer Potential: Research indicates that derivatives of this compound may exhibit activity against various cancer cell lines, making it a candidate for further pharmacological study.
  • Mechanism of Action: Its structure suggests it may act as an enzyme inhibitor, particularly in pathways involving carbamoyl transfer, which could be crucial in cancer therapy.
  • Structural Diversity: The compound's structure boasts several functional groups, enhancing its potential for creating a library of analogs with varied biological properties.
  • Research Interest: With ongoing studies in fields like medicinal chemistry and drug development, attention is growing on how slight modifications can affect the efficacy and safety of this compound.

As a chemist or student exploring this compound, one might consider the implications of its structure-activity relationship (SAR) in drug design, which emphasizes how small changes in a compound's structure can lead to significant differences in its therapeutic effects.

Overall, 3-pyridylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate represents a compelling intersection of organic chemistry and pharmacology, demonstrating the power of chemical compounds in developing new therapeutic strategies.

Synonyms
Entinostat
209783-80-2
ms-275
SNDX-275
MS 275
MS-27-275
Entinostat (MS-275)
SNDX 275
MS 27-275
entinostatum
1ZNY4FKK9H
pyridin-3-ylmethyl 4-((2-aminophenyl)carbamoyl)benzylcarbamate
BAY 86-5274
Carbamic acid, N-[[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]-, 3-pyridinylmethyl ester
N-(2-aminophenyl)-4-(N-(pyridin-3-ylmethoxycarbonyl)aminomethyl)benzamide
ENTINOSTAT [INN]
ENTINOSTAT [JAN]
Entinostat [USAN:INN]
ENTINOSTAT [USAN]
NSC706995
BAY86-5274
pyridin-3-ylmethyl {4-[(2-aminophenyl)carbamoyl]benzyl}carbamate
ENTINOSTAT [WHO-DD]
pyridin-3-ylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate
CHEMBL27759
MS-275-27
DTXSID0041068
CHEBI:132082
3-Pyridinylmethyl ((4-(((2-aminophenyl)amino)carbonyl)phenyl)methyl)carbamate
Carbamic acid, ((4-(((2-aminophenyl)amino)carbonyl)phenyl)methyl)-, 3-pyridinylmethyl ester
NSC 706995
NSC-706995
pyridin-3-ylmethyl 4-(2-aminophenylcarbamoyl)benzylcarbamate
ZK 244894
pyridin-3-ylmethyl N-({4-[(2-aminophenyl)carbamoyl]phenyl}methyl)carbamate
Carbamic acid, N-((4-(((2-aminophenyl)amino)carbonyl)phenyl)methyl)-, 3- pyridinylmethyl ester
N-[[4-[(2-aminoanilino)-oxomethyl]phenyl]methyl]carbamic acid 3-pyridinylmethyl ester
Entinostat(MS-27-275)
pyridin-3-ylmethyl (4-((2-aminophenyl)carbamoyl)benzyl)carbamate
pyridin-3-ylmethyl 4-((2-aminophenyl)carbamoyl)benzylcarbamate.
(pyridin-3-yl)methyl N-({4-[(2-aminophenyl)carbamoyl]phenyl}methyl)carbamate
(Pyridin-3-yl)methyl ((4-((2-aminophenyl)carbamoyl)phenyl)methyl)carbamate
(Pyridin-3-yl)methyl ({4-[(2-aminophenyl)carbamoyl]phenyl}methyl)carbamate
N-(2-aminophenyl)-4-[N-(pyridin-3-ylmethoxycarbonyl)aminomethyl]benzamide
Pyridin-3-ylmethyl ({4-[(2-aminophenyl)carbamoyl]phenyl}methyl)carbamate
pyridin-3-ylmethyl N-((4-((2-aminophenyl)carbamoyl)phenyl)methyl)carbamate
(pyridin-3-yl)methyl N-((4-((2-aminophenyl)carbamoyl)phenyl)methyl)carbamate
N-((4-((2-aminoanilino)-oxomethyl)phenyl)methyl)carbamic acid 3-pyridinylmethyl ester
N-(2-Aminophenyl)-4-(N-(pyridin-3-yl-methoxycarbonyl)aminomethyl)b enzamide
N-(2-Aminophenyl)-4-[N-(pyridin-3-yl-methoxycarbonyl)aminomethyl]b enzamide
PYRIDIN-3-YLMETHYL ((4-((2-AMINOPHENYL)CARBAMOYL)PHENYL)METHYL)CARBAMATE
CARBAMIC ACID, N-((4-(((2-AMINOPHENYL)AMINO)CARBONYL)PHENYL)METHYL)-, 3-PYRIDINYLMETHYL ESTER
MFCD08272435
Entinostat, free base
UNII-1ZNY4FKK9H
Entinostat (MS-275)?
benzamide-type inhibitor, 3
HDAC inhibitor SNDX-275
MLS006010183
Entinostat (JAN/USAN/INN)
SCHEMBL148309
Entinostat (MS-27-275)
GTPL7007
DTXCID8021068
BDBM19410
EX-A038
L01XX64
BCPP000155
GLXC-04607
HMS3426G07
HMS3648K12
HMS3654O11
HMS3744O17
BCP01824
HB3983
NSC756642
s1053
Entinostat (MS-275;SNDX-275)
[4-(2-Amino-phenylcarbamoyl)-benzyl]-carbamic acid pyridin-3-ylmethyl ester
3-pyridylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate
AKOS024262667
N-(2-Aminophenyl)-4-[N-(pyridin-3-yl-methoxycarbonyl)aminomethyl]benzamide
AC-8968
BCP9000967
Carbamic acid, 3-pyridinylmethyl ester
CCG-208680
CS-0511
DB11841
Entinostat (MS-275, SNDX-275)
FE15194
NSC-756642
SB16665
Carbamic acid, [[4-[[(2-aminophenyl)carbaonyl]phenyl]methyl]-, 3-pyridinylmethyl ester
NCGC00165833-01
NCGC00165833-02
NCGC00165833-03
NCGC00165833-04
NCGC00165833-11
NCGC00165833-13
AS-17906
BP-25653
HY-12163
NCI60_038022
SMR004458705
MS-275, A HDAC1 and HDAC3 inhibitor
E1454
NS00068485
SW219667-1
D09338
EN300-6488260
MS-275,Entinostat, SNDX-275, MS-27-275
SR-01000946382
Q1281020
SR-01000946382-1
BRD-K77908580-001-02-1
BRD-K77908580-001-04-7
BRD-K77908580-001-09-6
BRD-K77908580-001-10-4
Z2037280922
pyridin-3-ylmethyl4-((2-aminophenyl)carbamoyl)benzylcarbamate
N-[[4-[[(2-Aminophenyl)amino]carbonyl]phenyl]methyl]-3-pyridinylmethyl ester, carbamic acid
630-693-0
Carbamic acid, ((4-(((2-aminophenyl)amino)carbonyl)phenyl) methyl)-, 3-pyridinylmethyl ester
Carbamic acid, [[4-[[(2-aminophenyl)amino]carbonyl]phenyl] methyl]-, 3-pyridinylmethyl ester (9CI)
N-[[4-[[(2-Aminophenyl)amino]carbonyl]phenyl]methyl]carbamic acid 3-pyridinylmethyl ester;MS 27-275;MS 275