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Atorvastatin

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Identification
Molecular formula
C33H35FN2O5
CAS number
134523-00-5
IUPAC name
3-methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]butanoic acid
State
State

At room temperature, atorvastatin exists as a solid. It is typically found in tablet formulations designed for oral administration.

Melting point (Celsius)
159.00
Melting point (Kelvin)
432.15
Boiling point (Celsius)
204.00
Boiling point (Kelvin)
477.15
General information
Molecular weight
558.64g/mol
Molar mass
558.6440g/mol
Density
1.2100g/cm3
Appearence

Atorvastatin is typically a white to off-white crystalline powder. It is often supplied in its calcium salt form and is used in various pharmaceutical formulations.

Comment on solubility

Solubility of 3-methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]butanoic acid

The solubility of a compound is a crucial factor influencing its behavior in various chemical environments. For the compound 3-methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]butanoic acid (C33H35FN2O5), several aspects must be considered:

  • Polarity: Compounds with higher polarity typically exhibit better solubility in polar solvents. Given the presence of functional groups in this compound, it is likely to have moderate solubility in polar solvents such as water.
  • Hydrophilicity: The introduction of functional groups such as carboxylic acids and amines often enhances solubility due to their ability to form hydrogen bonds. This property may increase the compound's solubility in aqueous solutions.
  • Hydrophobic interactions: Conversely, the large hydrophobic pentanoyl and phenyl groups may hinder solubility in polar solvents. This might suggest that the compound could exhibit limited solubility.
  • Solvent considerations: This compound may demonstrate differing solubility profiles in organic solvents compared to aqueous solutions. For example, it may be more soluble in non-polar organic solvents.

In summary, while the solubility of 3-methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]butanoic acid may not be deterministically high, its unique structure suggests potential **moderate solubility in polar solvents** affected by its functional groups and overall hydrophobic character. As noted in solubility studies, “Understanding solubility is key to unlocking the potential applications of compounds in pharmacology and material science."

Interesting facts

Interesting Facts about 3-Methyl-2-[Pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]Butanoic Acid

This complex compound, often referred to simply for its structural elegance, holds significant appeal in both medicinal chemistry and materials science. Here are some captivating aspects:

  • Structural Diversity: The compound features a unique architecture that includes a 2H-tetrazole ring. This five-membered heterocyclic structure is well-known for enhancing biological activity and improving the pharmacokinetic properties of various compounds.
  • Potential Pharmacological Applications: As it combines different functional groups, including an amino acid moiety and a phenyl ring, this compound may exhibit a wide range of biological activities. Tetrazoles are particularly noteworthy in drug development due to their versatility!
  • Chemical Interactions: The presence of multiple aromatic systems can lead to enhanced π-π stacking interactions, which are crucial for the stabilization of molecular structures in biological targets.
  • Fusion of Fatty Acids: Incorporating pentanoyl functionality allows for increased lipophilicity, which can enhance cellular uptake and bioavailability, making it a point of interest in targeted drug delivery systems.
  • Chemists' Delight: This compound serves as an excellent example for students and professionals alike when exploring synthetic methodologies and reaction pathways for constructing complex organic molecules.

As one might state, “The beauty of chemistry lies in its complexity.” This compound exemplifies the creativity and intellectual challenge inherent in the field. With ongoing research, the full potential of 3-Methyl-2-[Pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]Butanoic Acid continues to unfold.


Synonyms
N-pentanoyl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-L-valine
943333-68-4
3-methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]butanoic acid
3-METHYL-2-(N-{[2'-(1H-1,2,3,4-TETRAZOL-5-YL)-[1,1'-BIPHENYL]-4-YL]METHYL}PENTANAMIDO)BUTANOIC ACID
L-Valsartan
NCGC00095139-01
137863-60-6
SCHEMBL2329
SCHEMBL8476946
CHEMBL1904197
CHEBI:94331
DTXSID30861343
HMS3370B04
HMS3393L12
(2R)-3-methyl-2-[pentanoyl-[[4-[2-(1H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]butanoic acid
BCP13366
BBL009903
MFCD18252868
STK711077
AKOS005530709
AKOS015895191
AB07510
NCGC00095139-02
NCGC00095139-04
SY102423
VS-02244
NS00000341
EN300-20052360
L000621
BRD-A14792000-001-01-1
Q27166154
N-pentanoyl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}valine
(R)-N-Valeryl-N-([2'-(1H-tetrazole-5-yl)-biphenyl-4-yl]-Methyl)-valine
(R)-[N-VALERYL-N-([2'-(1H-TETRAZOLE-5-YL)BIPHEN-4-YL]METHYL)VALINE)
3-methyl-2-[1-oxopentyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]butanoic acid
N-(1-Oxopentyl)-N-[[2a(2)-(2H-tetrazol-5-yl)[1,1a(2)-biphenyl]-4-yl]methyl]valine
(R)-2-[N-[[2 inverted exclamation mark -(5-Tetrazolyl)-4-biphenylyl]methyl]pentanamido]-3-methylbutanoic Acid
3-METHYL-2-(N-{[2'-(2H-1,2,3,4-TETRAZOL-5-YL)-[1,1'-BIPHENYL]-4-YL]METHYL}PENTANAMIDO)BUTANOIC ACID