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Trimethoprim

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Identification
Molecular formula
C14H18N4O3
CAS number
738-70-5
IUPAC name
3-[methyl-[2-[methyl-[3-(3,4,5-trimethoxybenzoyl)oxypropyl]amino]ethyl]amino]propyl 3,4,5-trimethoxybenzoate
State
State

In its pure form, Trimethoprim is a solid at room temperature, typically available as a crystalline powder.

Melting point (Celsius)
199.00
Melting point (Kelvin)
472.15
Boiling point (Celsius)
360.00
Boiling point (Kelvin)
633.15
General information
Molecular weight
290.32g/mol
Molar mass
290.3190g/mol
Density
1.2800g/cm3
Appearence

Trimethoprim appears as a white to yellowish-white crystalline powder. It is practically odorless and has a bitter taste.

Comment on solubility

Solubility of 3-[methyl-[2-[methyl-[3-(3,4,5-trimethoxybenzoyl)oxypropyl]amino]ethyl]amino]propyl 3,4,5-trimethoxybenzoate

The compound 3-[methyl-[2-[methyl-[3-(3,4,5-trimethoxybenzoyl)oxypropyl]amino]ethyl]amino]propyl 3,4,5-trimethoxybenzoate (C14H18N4O3) exhibits a unique solubility profile that can be influenced by several factors. Here are some important aspects to consider:

  • Polar and Non-Polar Characteristics: The presence of multiple methoxy groups (–OCH3) suggests that the compound may have both polar and non-polar characteristics, potentially affecting its solubility in various solvents.

  • Solvent Compatibility: This compound may be more soluble in organic solvents such as ethanol, chloroform, and acetone due to the non-polar aromatic components present, while its solubility in water could be limited.

  • Temperature Dependence: Solubility could increase with temperature, making heating a potential strategy to enhance dissolution rates in suitable solvents.

  • Influence of pH: The solubility may also vary with changes in pH, as the protonation or deprotonation of amino groups in different pH environments can alter its interaction with solvents.

In summary, the solubility of 3-[methyl-[2-[methyl-[3-(3,4,5-trimethoxybenzoyl)oxypropyl]amino]ethyl]amino]propyl 3,4,5-trimethoxybenzoate can be quite complex and is influenced by the compound’s unique structure and the nature of the solvent used. Understanding these solubility characteristics is essential for applications in chemical synthesis and formulation development.

Interesting facts

Interesting Facts About 3-[methyl-[2-[methyl-[3-(3,4,5-trimethoxybenzoyl)oxypropyl]amino]ethyl]amino]propyl 3,4,5-trimethoxybenzoate

This fascinating compound is a part of a larger class of chemicals known as benzoates, which often exhibit diverse biological activities. Here are some intriguing aspects that highlight its significance in the realm of chemistry:

  • Complex Structure: The compound features multiple functional groups, including amines and esters, which can significantly influence its chemical behavior and interaction with biological systems.
  • Potential Applications: Given its structure, this compound may have applications in pharmaceuticals, particularly as a drug candidate owing to its potential neuroprotective and anti-inflammatory properties.
  • Synthetic Pathways: The synthesis of such complex organic molecules often involves intricate multi-step processes that could provide insight into organic synthesis techniques and methodologies.
  • Structure-Activity Relationship (SAR): The analysis of the structure of this compound could lead to valuable SAR studies, helping chemists understand how the modifications to carbon chains or functional groups can affect biological activity.
  • Trimethoxy Groups: The presence of multiple methoxy groups could enhance solubility and bioavailability, making it an interesting subject for pharmacokinetics research.

As a future chemist or a biology student, understanding the intricate details of compounds like this can pave the way for innovative developments in drug designs that cater to specific therapeutic needs. The field of medicinal chemistry thrives on such complex compounds, and their potential can only be explored with diligent study and research.

Remember, as the famous chemist Linus Pauling once said, “The best way to have a good idea is to have a lot of ideas.” Exploring compounds like this could be the first step towards groundbreaking discoveries!

Synonyms
Hexobendine
Ditrimin
Ditrymine
Hexabendin
54-03-5
Hexobendinum
Ditrimine
Hexobendina
Hexobendinum [INN-Latin]
Hexobendina [INN-Spanish]
Hexobendine [USAN:INN:BAN]
ST 7090
EINECS 200-189-1
B6X4SYR93B
BRN 2200156
HEXOBENDINE [MI]
HEXOBENDINE [INN]
HEXOBENDINE [USAN]
HEXOBENDINE [MART.]
HEXOBENDINE [WHO-DD]
3,4,5-Trimethoxybenzoic acid, diester with 3,3'-(ethylenebis(methylimino))di-1-propanol
Benzoic acid, 3,4,5-trimethoxy-, 1,2-ethanediylbis((methylimino)-3,1-propanediyl) ester
3-[methyl-[2-[methyl-[3-(3,4,5-trimethoxybenzoyl)oxypropyl]amino]ethyl]amino]propyl 3,4,5-trimethoxybenzoate
4,7-Dimethyl-4,7-diazadecamethylenbis(3,4,5-trimethoxybenzoat)
DTXSID20202302
3,3'-(Ethylenebis(methylimino))di-1-propanol 3,4,5-trimethoxybenzoate diester
Benzoic acid, 3,4,5-trimethoxy-, diester with 3,3'-(ethylenebis(methylimino))di-1-propanol
Hexobendin
Hexobendinum (INN-Latin)
Hexobendina (INN-Spanish)
HEXOBENDINE (MART.)
(Ethane-1,2-diylbis(methylazanediyl))bis(propane-3,1-diyl) bis(3,4,5-trimethoxybenzoate)
Benzoic acid, 3,4,5-trimethoxy-, 1,2-ethanediylbis[(methylimino)-3,1-propanediyl] ester
3-[methyl(2-{methyl[3-(3,4,5-trimethoxybenzoyloxy)propyl]amino}ethyl)amino]propyl 3,4,5-trimethoxybenzoate
UNII-B6X4SYR93B
esobendina
3,4,5-Trimethoxybenzoic acid, diester with 3,3'-[ethylenebis(methylimino)]di-1-propanol
3-(methyl(2-(methyl(3-(3,4,5-trimethoxybenzoyloxy)propyl)amino)ethyl)amino)propyl 3,4,5-trimethoxybenzoate
Hexobendine (USAN/INN)
SCHEMBL125629
CHEMBL127300
C01DX06
DTXCID80124793
CHEBI:135843
BDBM50225480
DB13265
NS00007037
D04438
EN300-19767883
BRD-K23741141-003-01-1
BRD-K23741141-003-02-9
Q12745373
200-189-1
3-(Methyl[2-(methyl(3-[(3,4,5-trimethoxybenzoyl)oxy]propyl)amino)ethyl]amino)propyl 3,4,5-trimethoxybenzoate #
Benzoic acid, 3,4,5-trimethoxy-, 1,1'-[1,2-ethanediylbis[(methylimino)-3,1-propanediyl]] ester