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3-Hydroxyindolin-2-one

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Identification
Molecular formula
C8H7NO2
CAS number
13614-98-7
IUPAC name
3-hydroxyindolin-2-one
State
State

At room temperature, 3-Hydroxyindolin-2-one is in a solid state. It has a characteristic crystalline structure.

Melting point (Celsius)
174.00
Melting point (Kelvin)
447.00
Boiling point (Celsius)
422.00
Boiling point (Kelvin)
695.00
General information
Molecular weight
149.15g/mol
Molar mass
149.1480g/mol
Density
1.4401g/cm3
Appearence

3-Hydroxyindolin-2-one typically appears as a crystalline solid. It is characterized by its fine needle or plate-like crystals when purified. This compound is usually off-white to slightly beige in color, depending on the purity and specific conditions during its synthesis.

Comment on solubility

Solubility of 3-hydroxyindolin-2-one (C8H7NO2)

The solubility of 3-hydroxyindolin-2-one in various solvents can be described as follows:

  • Water: This compound has limited solubility in water due to its organic structure, which hinders strong interactions with water molecules.
  • Organic Solvents: 3-hydroxyindolin-2-one is generally more soluble in organic solvents such as
    • ethanol
    • dimethyl sulfoxide (DMSO)
    • acetone
  • Temperature Effects: Solubility can often increase with temperature; thus, heating the solvent may enhance the dissolution of 3-hydroxyindolin-2-one.

In summary, while 3-hydroxyindolin-2-one is not highly soluble in water, it finds better solubility in various organic solvents. This characteristic is crucial for applications in organic synthesis and drug formulation, where the choice of solvent can significantly affect the efficacy of the compound.

Interesting facts

Interesting Facts about 3-Hydroxyindolin-2-one

3-Hydroxyindolin-2-one is a unique organic compound that has garnered interest in both the academic and industrial realms of chemistry. Below are some notable points about this intriguing compound:

  • Chemical Structure: The compound features a bicyclic structure characteristic of indolines, with a hydroxyl group at the 3-position. This structural uniqueness contributes to its diverse reactivity and potential applications.
  • Biological Significance: Research indicates that derivatives of 3-hydroxyindolin-2-one exhibit various biological activities, including anti-inflammatory and antitumor properties. Its interaction with biological receptors has drawn attention for potential pharmaceutical applications.
  • Synthetic Versatility: 3-Hydroxyindolin-2-one can be synthesized through various methods, which allow chemists to explore modifications that can lead to novel derivatives. The explorations into its synthetic pathways have further expanded its applicability in organic synthesis.
  • Fluorescence Properties: This compound is known for its fluorescent properties, making it useful as a fluorescent probe in biochemical assays. Its ability to absorb and emit light is utilized in various sensing applications.
  • Interdisciplinary Interest: The unique properties of 3-hydroxyindolin-2-one have found its way into interdisciplinary research areas, including materials science, biochemistry, and organic electronics.

As scientists continue to investigate 3-hydroxyindolin-2-one, its potential for innovation in drug development and materials science makes it a compound worth studying closely. Its multifaced nature not only serves as a testament to the complexity of organic compounds, but also opens doors for future research and applications.

In the words of chemists exploring this compound, "3-Hydroxyindolin-2-one is more than just a molecule; it's a portal to new discoveries."

Synonyms
3-hydroxyindolin-2-one
Dioxindole
61-71-2
3-hydroxyoxindole
3-hydroxy-2,3-dihydro-1H-indol-2-one
3-Hydroxy-2-oxoindole
3-hydroxy-1,3-dihydroindol-2-one
1,3-Dihydro-3-hydroxy-2H-indol-2-one
3-hydroxy-2-indolinone
3-hydroxy-1,3-dihydro-2H-indol-2-one
CHEBI:28536
3-Hydroxy-indolin-2-one
CHEMBL2152717
2-Indolinone, 3-hydroxy-
Oxindole, 3-hydroxy-
NSC 26319
BRN 0082628
Oprea1_632211
SCHEMBL87439
2H-INDOL-2-ONE, 1,3-DIHYDRO-3-HYDROXY-
5-21-12-00189 (Beilstein Handbook Reference)
SGZFJWQQBHYNNF-UHFFFAOYSA-N
DTXSID801018937
AAA06171
NSC26319
BDBM50393075
NSC-26319
NSC822477
AKOS000249268
AKOS016904238
NSC-822477
SB65807
CS-0253475
EN300-64496
G58077
Q27103761
Z335244966
826-730-7