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Niacin

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Identification
Molecular formula
C6H5NO3
CAS number
59-67-6
IUPAC name
3-hydroxy-5-(hydroxymethyl)-2-methyl-pyridine-4-carboxylic acid
State
State

At room temperature, Niacin is a solid.

Melting point (Celsius)
236.00
Melting point (Kelvin)
509.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
137.14g/mol
Molar mass
137.1390g/mol
Density
1.4736g/cm3
Appearence

Niacin appears as a white crystalline powder and is odorless. It is known for having a slightly acidic taste. This compound may also appear as needles when crystallized from water.

Comment on solubility

Solubility of 3-hydroxy-5-(hydroxymethyl)-2-methyl-pyridine-4-carboxylic acid

The solubility of 3-hydroxy-5-(hydroxymethyl)-2-methyl-pyridine-4-carboxylic acid is influenced by its molecular structure and functional groups. As a carboxylic acid derivative, this compound exhibits some intriguing solubility characteristics, which can be summarized as follows:

  • Polar Functional Groups: The presence of hydroxyl (-OH) and carboxyl (-COOH) groups typically enhances solubility in polar solvents, such as water, due to hydrogen bonding capabilities.
  • Hydroxymethyl Side Chain: The hydroxymethyl group may further increase solubility by providing additional sites for hydrogen bonding interactions with solvent molecules.
  • Hydrophobic Influence: The methyl group introduces a hydrophobic region that might limit solubility to some extent, particularly in nonpolar solvents.

In summary, 3-hydroxy-5-(hydroxymethyl)-2-methyl-pyridine-4-carboxylic acid is expected to be moderately soluble in water and polar organic solvents while exhibiting significantly lower solubility in nonpolar environments. This duality in solubility characteristics underlines the balance between hydrophilic and hydrophobic interactions within the compound.

Interesting facts

Interesting Facts about 3-Hydroxy-5-(hydroxymethyl)-2-methyl-pyridine-4-carboxylic Acid

3-Hydroxy-5-(hydroxymethyl)-2-methyl-pyridine-4-carboxylic acid, often referred to as a complex pyridine derivative, has garnered significant interest in various fields of research and industry. Here are some captivating insights about this compound:

  • Role in Biochemistry: This compound is known to play an essential role in biological systems as a metabolite, which is important for the functioning of various biochemical pathways.
  • Antimicrobial Properties: Studies suggest that certain derivatives of this compound exhibit antimicrobial activity, making them potential candidates for developing new antibacterial agents.
  • Pharmaceutical Applications: Its structure is pertinent in medicinal chemistry, where modifications can lead to compounds with enhanced therapeutic effects.
  • Source of Natural Products: This compound can be derived from natural sources, often contributing to the diversity of plant metabolites that possess bioactive properties.
  • Research Significance: Research has shown that derivatives of this compound could have implications in treating diseases, owing to their ability to interact with specific biological targets.

The unique structure of 3-hydroxy-5-(hydroxymethyl)-2-methyl-pyridine-4-carboxylic acid allows for extensive research opportunities. According to recent studies, it is cited that "the modification of functional groups in such heterocyclic compounds can lead to improved biological activities and reduced side effects," highlighting its importance in drug discovery.

In conclusion, the intriguing properties and potential applications of 3-hydroxy-5-(hydroxymethyl)-2-methyl-pyridine-4-carboxylic acid ensure its continued relevance in both academic research and pharmaceutical development.

Synonyms
4-Pyridoxic acid
82-82-6
Pyridoxic acid
4-Pyridoxinic acid
4-Pyridoxylic acid
4-Pyridoxate
4-Pyridoxinecarboxylic acid
4-Pyridoxinsaeure
2-Methyl-3-hydroxy-4-carboxy-5-hydroxymethylpyridine
3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinic acid
3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carboxylic acid
3-Hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxylic acid
4-Pyridoxinate
4-Pyridoxylate
4-Pyridinecarboxylic acid, 3-hydroxy-5-(hydroxymethyl)-2-methyl-
EINECS 201-440-8
NSC 41814
BRN 0384006
4-Pyridoxinecarboxylate
4-Pyridoxinsaeure [German]
NSC-41814
ISONICOTINIC ACID, 3-HYDROXY-5-(HYDROXYMETHYL)-2-METHYL-
3-hydroxy-5-hydroxymethyl-2-methyl-isonicotinsaeure
PYRIDOXIC ACID, 4-
4-PYRIDOXIC ACID [MI]
CHEBI:17405
5-22-05-00379 (Beilstein Handbook Reference)
5K18793O8D
3-hydroxy-5-hydroxymethyl-2-methyl-isonicotinate
3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinate
3-hydroxy-5-(hydroxymethyl)-2-methyl-Isonicotinate
3-hydroxy-5-hydroxymethyl-2-methyl-isonicotinic acid
3-hydroxy-5-(hydroxymethyl)-2-methyl-Isonicotinic acid
3-Hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxylate
4 Pyridoxic Acid
4 Pyridoxinic Acid
4 Pyridoxylic Acid
NSC41814
Pyridoxinecarboxylic Acid
C00847
UNII-5K18793O8D
MFCD00006334
bmse000930
4-Pyridoxic acid, >=98%
SCHEMBL195230
LCZC2536
DTXSID20861650
AKOS030530767
AS-77155
DB-056662
HY-113493
CS-0062390
NS00014634
D97439
3-hydroxy-2-methyl-5-methylol-isonicotinic acid
Q27102382
F883B77C-B8C5-4061-8516-221CA6F8ACAC
201-440-8