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Tenofovir disoproxil

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Identification
Molecular formula
C9H14N5O4P
CAS number
147127-20-6
IUPAC name
[3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methyl phosphono hydrogen phosphate
State
State

At room temperature, Tenofovir disoproxil is a solid.

Melting point (Celsius)
115.00
Melting point (Kelvin)
388.20
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
287.21g/mol
Molar mass
287.2130g/mol
Density
1.4900g/cm3
Appearence

Tenofovir disoproxil is typically found as a white to off-white crystalline powder. It is practically odorless.

Comment on solubility

Solubility of [3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methyl phosphono hydrogen phosphate

The compound [3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methyl phosphono hydrogen phosphate, with the chemical formula C9H14N5O4P, exhibits interesting solubility characteristics that are influenced by its molecular structure and the presence of functional groups. Understanding its solubility is crucial for various applications in biochemical research and pharmaceutical formulation. Here are some key aspects to consider:

  • Polarity: Due to the presence of multiple polar groups, such as hydroxyl (-OH) and phosphate (-PO4H), the compound is likely to be soluble in polar solvents.
  • Hydrogen Bonding: The ability to form hydrogen bonds enhances its solubility in water, as these interactions can stabilize the compound in solution.
  • Solvent Compatibility: While it may show good solubility in aqueous solutions, the extent may vary in organic solvents, highlighting the importance of testing various solvents for optimal solubility.
  • pH Influence: The solubility may also be affected by the pH of the solution, as changes in acidity can alter the ionization of the phosphate group.

In conclusion, the solubility of [3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methyl phosphono hydrogen phosphate is expected to be high in polar solvents like water, primarily due to its polar molecular structure and functional groups. Understanding its solubility behavior is essential for optimizing its use in scientific applications.

Interesting facts

Exploring [3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methyl phosphono hydrogen phosphate

This fascinating compound offers an intersection between the realms of organic chemistry and biochemistry. Here are some intriguing aspects that are sure to pique your interest:

  • Complex Structure: The compound features a unique combination of a tetrahydrofuran ring and pyrimidine moiety. This structural complexity can lead to interesting interactions in biological systems.
  • Biological Relevance: Compounds like this one may have significant roles in enzymatic processes and can act as potential **enzyme inhibitors**, which are essential in drug design and development.
  • Potential Pharmacological Applications: Researchers are increasingly focused on the **phosphono** group, which can enhance the biological activity of compounds. This opens potential avenues for creating new therapeutic agents.
  • Analog to Nucleotide Structures: The presence of phosphonate groups in the structure offers an interesting analog to nucleotides, thus hinting at possible applications in genetic engineering and molecular biology.
  • Research Significance: Scientists continue to explore derivatives of similar compounds for their potential as **antitumor agents**. This area of research emphasizes the importance of modifying small molecules to enhance their efficacy and specificity.

In conclusion, the intricate arrangement of atoms within [3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methyl phosphono hydrogen phosphate not only highlights its potential in synthetic chemistry but also raises questions regarding its biological implications. As you delve deeper into this compound, consider how small changes in molecular design can lead to groundbreaking advancements in science and medicine.

Synonyms
1-{2-deoxy-5-o-[hydroxy(phosphonooxy)phosphoryl]pentofuranosyl}-5-methylpyrimidine-2,4(1h,3h)-dione
[3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl phosphono hydrogen phosphate
[hydroxy-[[3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)-oxolan-2-yl]methoxy]phosphoryl]oxyphosphonic acid
(3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl)methyl phosphono hydrogen phosphate
1-(2-Deoxy-5-o-(hydroxy(phosphonooxy)phosphoryl)pentofuranosyl)-5-methylpyrimidine-2,4(1h,3h)-dione
DTXSID60862025