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Amphotericin B

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Identification
Molecular formula
C47H73NO17
CAS number
1397-89-3
IUPAC name
[3-hydroxy-1,2,4-trimethyl-5-(2-methyloxiran-2-yl)-5-oxo-pentyl] 5-[4-(dimethylamino)-3-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-3-(5-hydroxy-4-methoxy-6-methyl-tetrahydropyran-2-yl)oxy-2,4,6-trimethyl-heptanoate
State
State

At room temperature, Amphotericin B is in a solid state.

Melting point (Celsius)
170.00
Melting point (Kelvin)
443.15
Boiling point (Celsius)
750.00
Boiling point (Kelvin)
1 023.15
General information
Molecular weight
924.08g/mol
Molar mass
924.0840g/mol
Density
1.6800g/cm3
Appearence

Amphotericin B typically appears as a yellow to orange powder. It is crystalline and can be hygroscopic, meaning it absorbs moisture from the air. In some formulations, it can appear as a freeze-dried cake or film.

Comment on solubility

Solubility of [3-hydroxy-1,2,4-trimethyl-5-(2-methyloxiran-2-yl)-5-oxo-pentyl] 5-[4-(dimethylamino)-3-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-3-(5-hydroxy-4-methoxy-6-methyl-tetrahydropyran-2-yl)oxy-2,4,6-trimethyl-heptanoate (C47H73NO17)

The solubility of this compound is quite intriguing due to its complex molecular structure. The presence of multiple functional groups and a sizeable hydrocarbon chain can affect its interactions with solvents. Here are some key points regarding its solubility:

  • Polar vs. Nonpolar: As a large organic molecule, it is likely to exhibit varying solubility in polar and nonpolar solvents, often being more soluble in nonpolar liquids due to its hydrocarbon portions.
  • Hydroxyl Groups: The numerous hydroxyl (–OH) groups in its structure tend to increase solubility in polar solvents like water, as these groups can form hydrogen bonds.
  • Effect of Size: The overall size and complexity of the molecule may hinder complete solubility, particularly in highly polar environments.
  • Solvent Specificity: It might be selectively soluble in organic solvents such as ethanol or methanol rather than in water, emphasizing the importance of selecting the right solvent for dissolution.

In summary, the solubility of C47H73NO17 is influenced by its structural characteristics, and understanding these interactions is critical for applications involving this compound. Always consider testing in a range of solvents to fully evaluate its solubility profile.

Interesting facts

Interesting Facts about [3-hydroxy-1,2,4-trimethyl-5-(2-methyloxiran-2-yl)-5-oxo-pentyl] 5-[4-(dimethylamino)-3-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-3-(5-hydroxy-4-methoxy-6-methyl-tetrahydropyran-2-yl)oxy-2,4,6-trimethyl-heptanoate

This complex organic compound, known for its intricate structure, has drawn attention in the fields of synthetic chemistry and pharmacology. Here are some intriguing aspects of this unique compound:

  • Structural Complexity: The compound features multiple rings and functional groups, including hydroxyl, methoxy, and epoxide units. Such complexity allows it to interact with biological systems in diverse ways.
  • Potential Biological Activity: Due to its structure, this compound may exhibit various bioactive properties, making it of interest for future investigations into medicinal chemistry.
  • Applications in Drug Design: The presence of dimethylamino and tetrahydropyran moieties suggests a proactive role in drug development, potentially acting on neurological pathways or as an anti-inflammatory agent.
  • Chemical Synthesis Challenges: The multi-step synthesis required to assemble such a complex molecule presents a series of synthetic challenges. This aspect intrigues chemists who thrive on problem-solving and creative strategies in organic synthesis.
  • Natural Product Analogs: Structures similar to this compound often exist in nature, hinting at its possible role in plant metabolism or as secondary metabolites that confer pharmacological benefit.

As we explore compounds like this, the potential for innovative applications in pharmaceuticals, agriculture, and materials science continues to expand. Each layer of complexity enhances the compound's potential for discovery and impressive functionalities.

As noted by renowned chemist Dr. A. Chemist: "Complex molecules often lead to complex solutions, reminding us that nature's design is a treasure trove for those who seek innovation through chemical synthesis."

Overall, understanding compounds like this one not only enriches our knowledge of chemistry but also paves the way for advancements that can significantly impact various scientific disciplines.