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3-ethyl-3-phenylpiperidine-2,6-dione

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Identification
Molecular formula
C13H15NO2
CAS number
4292-91-9
IUPAC name
3-ethyl-3-phenyl-piperidine-2,6-dione
State
State

At room temperature, 3-ethyl-3-phenylpiperidine-2,6-dione is typically found as a solid. It remains stable and does not react readily with common substances at ambient conditions.

Melting point (Celsius)
104.00
Melting point (Kelvin)
377.15
Boiling point (Celsius)
220.00
Boiling point (Kelvin)
493.15
General information
Molecular weight
217.27g/mol
Molar mass
217.2700g/mol
Density
1.1234g/cm3
Appearence

3-Ethyl-3-phenylpiperidine-2,6-dione commonly appears as a white crystalline solid. It is typically odorless and stable under standard conditions of temperature and pressure.

Comment on solubility

Solubility of 3-ethyl-3-phenyl-piperidine-2,6-dione (C13H15NO2)

The solubility of 3-ethyl-3-phenyl-piperidine-2,6-dione in various solvents can be quite interesting, as it typically depends on several factors, including the polarity of the solvent, temperature, and the compound's structure. Generally, compounds featuring both polar and nonpolar functional groups yield varying solubility characteristics.

Key Points on Solubility:

  • Polar Solvents: 3-ethyl-3-phenyl-piperidine-2,6-dione may exhibit limited solubility in water due to its relatively nonpolar regions.
  • Nonpolar Solvents: The compound is likely to be more soluble in organic solvents such as chloroform or diethyl ether as they better interact with its hydrophobic characteristics.
  • Temperature Influence: Increased temperatures often enhance solubility for many organic compounds, including this one.
  • pH Dependency: The solubility can also be affected by the pH of the solution, especially if the compound can ionize under certain conditions.

As a general rule, the phrase "like dissolves like" applies here, hinting that similar types of solvent and solute will result in greater solubility. Thus, while the solubility of 3-ethyl-3-phenyl-piperidine-2,6-dione can be specific to its chemical behavior, understanding its interaction with various solvents is crucial for practical applications.

Interesting facts

Exploring 3-ethyl-3-phenyl-piperidine-2,6-dione

The compound 3-ethyl-3-phenyl-piperidine-2,6-dione is a fascinating member of the piperidine family, which is well-known for its significance in medicinal chemistry and organic synthesis. This compound exhibits unique structural features and chemical properties that make it worthy of discussion.

Structural Insights

3-ethyl-3-phenyl-piperidine-2,6-dione boasts a piperidine ring that is modified by both ethyl and phenyl groups, contributing to its biological activity and molecular versatility. Here are some key elements of its structure:

  • Piperidine skeleton: This six-membered ring is a fundamental building block in many pharmaceuticals.
  • Substituents: The ethyl and phenyl substituents enhance its reactivity and potential interactions with biological targets.

Biological Relevance

This compound is not only interesting because of its structural characteristics but also due to its potential pharmacological applications. Chemical entities that resemble 3-ethyl-3-phenyl-piperidine-2,6-dione may exhibit:

  • Analgesic properties: With modifications in similar frameworks, compounds can offer pain-relief benefits.
  • Antidepressant effects: Research into piperidine derivatives has revealed mood-enhancing properties.

Synthesis and Applications

One of the intriguing aspects of 3-ethyl-3-phenyl-piperidine-2,6-dione is its synthetic accessibility, allowing for exploration in various fields:

  • Organic synthesis: It can serve as an intermediate in the synthesis of more complex drugs.
  • Research chemical: Scientists often use derivatives for studies into their biological mechanisms and interactions.

In summary, 3-ethyl-3-phenyl-piperidine-2,6-dione exemplifies how structure and functionality converge to create compounds with potential real-world applications in healthcare, making it a compelling subject for further study and exploration.

Synonyms
glutethimide
Sarodormin
Elrodorm
Noxyron
Glutethimid
Doriden
Glutetimid
Rigenox
Gluthetimide
Glutathimid
Glutetimide
Glimid
Noxiron
Alfimid
Ondasil
Gimid
2-Ethyl-2-phenylglutarimide
77-21-4
Doriden-sed
Glutethimidum
Glutetimida
Glutetimidu
2,6-Piperidinedione, 3-ethyl-3-phenyl-
Glutarimide, 2-ethyl-2-phenyl-
2-Phenyl-2-ethylglutaric acid imide
3-Ethyl-3-phenyl-2,6-dioxopiperidine
3-Ethyl-3-phenyl-2,6-piperidinedione
3-ethyl-3-phenylpiperidine-2,6-dione
3-Phenyl-3-ethyl-2,6-dioxopiperidine
3-Ethyl-3-phenyl-2,6-diketopiperidine
3-Phenyl-3-ethyl-2,6-diketopiperidine
Phenyl-aethyl-glutarsaeureimid
CC 11511
Glutethimidum [INN-Latin]
Glutetimida [INN-Spanish]
alpha-Ethyl-alpha-phenylglutarimide
alpha-Phenyl-alpha-ethylglutarimide
NSC 95239
HSDB 3088
alpha-Phenyl-alpha-ethylglutaric acid imide
UNII-C8I4BVN78E
EINECS 201-012-0
C8I4BVN78E
NSC-95239
DTXSID1023102
AI3-50601
Glutethimide [USP:INN:BAN]
CHEBI:5439
DTXCID303102
.alpha.-Ethyl-.alpha.-phenylglutarimide
.alpha.-Phenyl-.alpha.-ethylglutarimide
NCGC00159407-02
NCGC00159407-04
Dorimide
Glutetimide [DCIT]
Glutetimidu [Polish]
dl-Glutethimide
Glutethimidum (INN-Latin)
Glutetimida (INN-Spanish)
.alpha.-Phenyl-.alpha.-ethylglutaric acid imide
GLUTETHIMIDE (MART.)
GLUTETHIMIDE [MART.]
Glutethimide (USP:INN:BAN)
CAS-77-21-4
Doriden (TN)
Phenyl-aethyl-glutarsaeureimid [German]
Glutethimide (JAN/INN)
Glutethamide
DEA No. 2550
GLUTETHIMIDE [MI]
GLUTETHIMIDE [INN]
GLUTETHIMIDE [JAN]
2, 3-ethyl-3-phenyl-
GLUTETHIMIDE [HSDB]
CHEMBL1102
GLUTETHIMIDE [VANDF]
GLUTETHIMIDE [WHO-DD]
SCHEMBL113708
WLN: T6VMVTJ D2 DR
GTPL7192
N05CE01
GLUTETHIMIDE [ORANGE BOOK]
NSC95239
Tox21_111641
AKOS015897742
Tox21_111641_1
DB01437
GLUTARIMIDE, 2-ETHYL-2-PHENYL
NCGC00159407-03
AC-16077
NS00008281
2,6-PIPERIDINEDIONE, 3-ETHYL-3-PHENYL
C07489
D00532
Q414236
3-ethyl-6-hydroxy-3-phenyl-2,3,4,5-tetrahydropyridin-2-one
201-012-0