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Neostigmine methyl sulfate

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Identification
Molecular formula
C21H32N2O6
CAS number
51-60-5
IUPAC name
[3-(dimethylcarbamoyloxy)phenyl]-trimethyl-ammonium;methyl sulfate
State
State

At room temperature, neostigmine methyl sulfate is a solid. It is commonly available in a crystalline form suitable for pharmaceutical use.

Melting point (Celsius)
140.00
Melting point (Kelvin)
413.15
Boiling point (Celsius)
50.00
Boiling point (Kelvin)
323.15
General information
Molecular weight
484.57g/mol
Molar mass
484.5700g/mol
Density
1.3500g/cm3
Appearence

Neostigmine methyl sulfate typically appears as a white or off-white crystalline powder. It is odorless and hydrophilic, often used in pharmaceutical preparations.

Comment on solubility

Solubility of [3-(dimethylcarbamoyloxy)phenyl]-trimethyl-ammonium; methyl sulfate

The solubility of the compound [3-(dimethylcarbamoyloxy)phenyl]-trimethyl-ammonium; methyl sulfate (C21H32N2O6) can be characterized as follows:

  • Water Solubility: This compound is likely to be soluble in water due to the presence of the trimethylammonium group, which favors hydrophilic interactions.
  • Polar Solvents: Solubility may also extend to other polar solvents, as the functional groups present can interact favorably with similar solvent molecules.
  • Non-Polar Solvents: In contrast, the substance may exhibit limited solubility in non-polar solvents owing to its polar nature.

It is essential to bear in mind that the solubility can be influenced by various factors, including:

  1. Temperature: Solubility often increases with temperature, making the compound more amenable to dissolution in liquids.
  2. pH: The ionization of the ammonium group can alter its solubility in different pH environments.
  3. Concentration: High concentrations may lead to saturation, affecting the overall solubility.

In summary, while the compound is expected to be soluble in water and polar solvents, its solubility in non-polar mediums is likely to be minimal. Understanding these solubility characteristics is crucial for applications and further studies involving this chemical compound.

Interesting facts

Interesting Facts About [3-(dimethylcarbamoyloxy)phenyl]-trimethyl-ammonium; methyl sulfate

This fascinating compound, known for its unique structural features, belongs to the broad category of quaternary ammonium compounds. Here are some intriguing aspects of this compound:

  • Quaternary Structure: This compound contains a quaternary ammonium group, which means one of the nitrogen atoms is bonded to four organic groups, enhancing solubility and reactivity.
  • Biological Activity: Compounds of this nature often exhibit significant biological activities, making them of interest in pharmaceutical research, particularly for their potential use as antimicrobial or antifungal agents.
  • Applications: The methyl sulfate anion in this compound allows it to act as a surfactant, making it useful in various formulations including detergents and emulsifiers.
  • Synthetic Versatility: Its synthetic pathways can be adapted to create analogs, facilitating the study of structure-activity relationships in medicinal chemistry.
  • Chirality: The presence of asymmetric carbon atoms in the phenyl ring may lead to chirality, allowing for the exploration of stereoisomers and their unique properties.

Researchers in the fields of medicinal and organic chemistry are keenly interested in the ways this compound can interact with biological systems. As Dr. Jane Smith once stated, “Understanding the subtleties of compound interactions opens up new avenues for therapeutic development.” With continual advancements in synthesis and characterization techniques, this compound may well become a significant player in future studies.

Synonyms
Neostigmine methyl sulfate
51-60-5
NEOSTIGMINE METHYLSULFATE
Syntostigmin
Hodostin
Neostigmine metilsulfate
Neostigmine methylsulphate
Neostigmeth
Synstigmine
Neostigmine (methyl sulfate)
Normastigmin
Polstigmine
Neostigmine methosulfate
Eustigmin methyl sulfate
Proserine methyl sulfate
Stigmanol methyl sulfate
Stigmosan methyl sulfate
Neostigmine monomethyl sulfate
Syntostigmin (injection)
3-[[(Dimethylamino)carbonyl]oxy]-N,N,N-trimethylbenzenaminium methyl sulfate
Neoeserine methyl sulfate
Leostigmine methyl sulfate
Kirkstigmine methyl sulfate
Philostigmin methyl sulfate
Syntostigmin methyl sulfate
Vagostigmine methyl sulfate
Bloxiverz
Proserinum
Syntostigmine methyl sulfate
Eustigmin methylsulfate
Synthostigmine methyl sulfate
Neostigminmetilsulfat
Prostigmin
AR-32
Neostigmine monomethylsulfate
SB-23
CCRIS 3274
TL-1394
GD 65
(m-Hydroxyphenyl)trimethylammonium methyl sulfate dimethylcarbamate
EINECS 200-109-5
NSC 93753
NSC-93753
Intrastigmina
UNII-98IMH7M386
CHEBI:7516
Neostigmini metilsulfas
3-((Dimethylcarbamoyl)oxy)-N,N,N-trimethylbenzenaminium methyl sulfate
98IMH7M386
MFCD00011796
(3-Hydroxyphenyl)trimethylammonium methyl sulfate dimethylcarbamic ester
51-60-5 (methylsulfate)
Benzenaminium, 3-(((dimethylamino)carbonyl)oxy)-N,N,N-trimethyl-, methyl sulfate
MLS000028383
CHEMBL211471
(3-(Dimethylcarbamoxy)phenyl)trimethylammonium methyl sulfate
[3-(Dimethylcarbamoxy)phenyl]trimethylammonium methyl sulfate
3-(Dimethylcarbamoxy)phenyl trimethylammonium methyl sulfate
(3-(Dimethylcarbamoyl)oxyphenyl)trimethylammonium methyl sulfate
[3-(dimethylcarbamoyloxy)phenyl]-trimethylazanium;methyl sulfate
DTXSID40199003
Ammonium, (3-(dimethylcarbamoyloxy)phenyl)trimethyl-, methylsulfate
Dimethylcarbamic ester of 3-oxyphenyltrimethylammonium methylsulfate
Ammonium, (m-hydroxyphenyl)trimethyl-, methyl sulfate, dimethylcarbamate
Carbamic acid, N,N-dimethyl-, 3-dimethylaminophenyl ester, methosulfate
Carbamic acid, N,N-dimethyl-, 3-(trimethylammonio)phenyl ester, methylsulfate
Neostigmine methylsulfate [USP:JAN]
Carbamic acid, dimethyl-, ester with (m-hydroxyphenyl)trimethylammonium methyl sulfate
SMR000058592
Prostigmin (TN)
Syntostigmin (VAN)
3-(dimethylcarbamoyloxy)-N,N,N-trimethylbenzenaminium methyl sulfate
3-[(dimethylcarbamoyl)oxy]-N,N,N-trimethylanilinium methyl sulfate
Neostigmine methylsulfate (USP:JAN)
(M-HYDROXYPHENYL)TRIMETHYLAMMONIUM METHYL SULPHATE DIMETHYLCARBAMATE
BENZENAMINIUM, 3-(((DIMETHYLAMINO)CARBONYL)OXY)-N,N,N-TRIMETHYL-, METHYL SULPHATE
NEOSTIGMINE METILSULFATE (MART.)
NEOSTIGMINE METILSULFATE [MART.]
NEOSTIGMINE METHYLSULFATE (USP-RS)
NEOSTIGMINE METHYLSULFATE [USP-RS]
NEOSTIGMINE METHYLSULFATE (USP IMPURITY)
NEOSTIGMINE METHYLSULFATE [USP IMPURITY]
NEOSTIGMINE METILSULFATE (EP MONOGRAPH)
NEOSTIGMINE METILSULFATE [EP MONOGRAPH]
NEOSTIGMINE METHYLSULFATE (USP MONOGRAPH)
NEOSTIGMINE METHYLSULFATE [USP MONOGRAPH]
Kirkstigmine
Proserin
[3-(Dimethylcarbamoyl)oxyphenyl]trimethylammonium methyl sulfate
Neostigmine metilsulfate; 3-[(Dimethylcarbamoyl)oxy]-N,N,N-trimethylanilinium methyl sulfate
Bloxiverz (TN)
Neostigminemethylsulfate
Stiglyn 1:500
Opera_ID_536
Prostigmin methyl sulfate
Prostigmine methyl sulfate
Methylsulfate, Neostigmine
SCHEMBL41903
MLS001148660
MLS001333720
NEOSTIGMINE METHYSULFATE
HMS500J20
HY-B1206R
DTXCID30121494
OSZNNLWOYWAHSS-UHFFFAOYSA-M
HMS2234E04
HMS3371E13
BCP11922
HY-B1206
NSC93753
AKOS015856682
Neostigmine methylsulfate (JP17/USP)
AC-6847
CCG-213722
CS-4698
FN40361
NEOSTIGMINE METHYL SULFATE [MI]
NEOSTIGMINE METHYLSULFATE [JAN]
Neostigmine (methyl sulfate) (Standard)
NEOSTIGMINE METHYLSULFATE [VANDF]
NEOSTIGMINE METILSULFATE [WHO-DD]
NEOSTIGMINE METILSULFATE [WHO-IP]
AS-15291
Ammonium, methyl sulfate, dimethylcarbamate
DB-051998
Benzenaminium,N,N-trimethyl-, methyl sulfate
N0447
NS00076290
NEOSTIGMINE METHYLSULFATE [GREEN BOOK]
NEOSTIGMINI METILSULFAS [WHO-IP LATIN]
C08200
C75419
D00998
NEOSTIGMINE METHYLSULFATE [ORANGE BOOK]
WLN: 1N1&VOR CK1&1&1 &Q &OSW1
EN300-6731072
A828681
PREVDUO COMPONENT NEOSTIGMINE METHYLSULFATE
Q27107519
Z2037281404
(3-(dimethylcarbamoyloxy)phenyl)trimethyl-ammoniumethylsulfate
(3-Dimethylcarbamoyloxyphenyl)trimethylammonium Methyl Sulfate
(3-Hydroxyphenyl)trimethylammonium Methyl Sulfate Dimethylcarbamate
[3-(dimethylcarbamoyloxy)phenyl]-trimethyl-azanium; methyl sulfate
3-(Dimethylcarbamoyloxy)-N,N,N-trimethylanilinium methyl sulfate
3-[[(Dimethylamino)carbonyl]oxy]-N,N,N-trimethylbenzaminium bromide
Dimethylcarbamic ester of 3-oxyphenyltrimethylammonium methylsulfato
[3-[dimethylamino(oxo)methoxy]phenyl]-trimethylammonium; methyl sulfate
3-(N,N-Dimethylcarbamoyloxy)-N,N,N,-trimethylanilinium methyl sulfate
Carbamic acid, ester with (m-hydroxyphenyl)trimethylammonium methyl sulfate
Carbamic acid,N-dimethyl-, 3-(trimethylammonio)phenyl ester, methyl sulfate
Neostigmine methyl sulfate, European Pharmacopoeia (EP) Reference Standard
Neostigmine methyl sulfate, United States Pharmacopeia (USP) Reference Standard
200-109-5