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Buprenorphine

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Identification
Molecular formula
C29H41NO4
CAS number
53152-21-9
IUPAC name
3-(cyclopropylmethyl)-7-methylene-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol
State
State

At room temperature, buprenorphine is a solid. It is stable under standard conditions of temperature and pressure.

Melting point (Celsius)
210.00
Melting point (Kelvin)
483.15
Boiling point (Celsius)
633.15
Boiling point (Kelvin)
906.15
General information
Molecular weight
467.64g/mol
Molar mass
467.6390g/mol
Density
1.2101g/cm3
Appearence

Buprenorphine is generally present as a white or off-white crystalline powder. It is odorless and has a bitter taste. The fine powder form increases its surface area to enhance solubility and interaction with solvents during formulation.

Comment on solubility

Solubility of 3-(cyclopropylmethyl)-7-methylene-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol

The solubility of the compound with the formula C29H41NO4 presents some intriguing characteristics, largely influenced by its complex molecular structure. Here are several observations regarding its solubility:

  • Polar vs Nonpolar Nature: The compound contains various functional groups which may lend it a degree of polarity, but the overall large hydrocarbon framework could suggest limited solubility in polar solvents.
  • Interactions with Solvents: Likely to have favorable interactions with nonpolar solvents such as hexane or dichloromethane due to its substantial hydrophobic regions.
  • Solubility in Water: Typically, compounds of this type exhibit low water solubility owing to their bulky structure and potential steric hindrance.
  • Temperature Influence: Solubility may increase with temperature, a common behavior for organic compounds, leading to greater dissolution in certain solvents when heated.

In summary, while the exact solubility characteristics of C29H41NO4 may require empirical testing for precise quantification, its structural properties suggest it would exhibit limited aqueous solubility and a more favorable profile in nonpolar environments. As with many organic compounds, understanding these solubility aspects is crucial for applications in synthesis and formulation.

Interesting facts

Interesting Facts about 3-(Cyclopropylmethyl)-7-methylene-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol

This compound, with its intricate structure, showcases the fascinating complexity of organic chemistry. Here are some key points about this unique molecule:

  • Structural Complexity: The compound features a fused ring system that includes a benzofuro[3,2-e]isoquinoline scaffold, highlighting the rich chemistry associated with polycyclic compounds.
  • Potential Biological Activity: Compounds like this one are often investigated for their potential pharmacological properties. The presence of multiple functional groups may contribute to diverse bioactivity, including anti-inflammatory or neuroprotective effects.
  • Cyclopropyl Group: The cyclopropylmethyl moiety is particularly interesting, as cyclopropyl-containing compounds have been known to exhibit unique properties such as increased stability and reactivity, making them valuable in medicinal chemistry.
  • Synthesis Challenges: The synthetic pathways to create such complex molecules can be elaborate and may require multi-step reactions. This entails an understanding of advanced organic reactions, including cyclizations and functional group transformations.
  • Interdisciplinary Interest: The study of this compound bridges multiple fields such as organic chemistry, medicinal chemistry, and pharmacology, making it a topic of interest for researchers across disciplines.

As science continues to explore the depths of organic compounds, structures like that of 3-(cyclopropylmethyl)-7-methylene-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol serve as a reminder of the intricate beauty and potential within chemical compounds. The journey of understanding and utilizing such compounds could lead to the development of novel therapies that can significantly impact health and medicine.

Synonyms
NALMEFENE-HCl
SCHEMBL13267538
BDBM85326
DTXSID70860678
Morphinan-3,14-diol, 17-(cyclopropylmethyl)-4,5-epoxy-6-methylene-, (5.alpha.)-
WJBLNOPPDWQMCH-UHFFFAOYSA-N
CAS_119501
NSC_119501
L024021
BRD-A72767275-003-01-6
17-(cyclopropylmethyl)-6-methylidene-4,5-epoxymorphinan-3,14-diol
17-(Cyclopropylmethyl)-4,5.alpha.-epoxy-6-methylenemorphinan-3,14-diol
4-(cyclopropylmethyl)-14-methylidene-12-oxa-4-azapentacyclo[9.6.1.0(1),(1)(3).0?,(1)?.0?,(1)?]octadeca-7(18),8,10-triene-10,17-diol