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3-[bis(2-Thienyl)methylene]-1-methylpiperidine

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Identification
Molecular formula
C15H15NS2
CAS number
129273-92-9
IUPAC name
3-[bis(2-thienyl)methylene]-1-methyl-piperidine
State
State
At room temperature, 3-[bis(2-thienyl)methylene]-1-methylpiperidine is typically found as a solid.
Melting point (Celsius)
153.00
Melting point (Kelvin)
426.15
Boiling point (Celsius)
325.00
Boiling point (Kelvin)
598.15
General information
Molecular weight
275.43g/mol
Molar mass
275.4400g/mol
Density
1.1800g/cm3
Appearence

3-[bis(2-Thienyl)methylene]-1-methylpiperidine appears as a yellowish crystalline solid. It has a distinct musty odor.

Comment on solubility

Solubility of 3-[bis(2-thienyl)methylene]-1-methyl-piperidine: C15H15NS2

The solubility of 3-[bis(2-thienyl)methylene]-1-methyl-piperidine in various solvents can be quite intriguing due to its unique structure. This compound contains both an aromatic system and a piperidine ring, which influence its solubility characteristics.
Here are key points to consider regarding its solubility:

  • Polar vs. Non-Polar Solvents: Due to the presence of sulfur atoms in the thiophene rings, the compound is likely to exhibit better solubility in polar organic solvents such as ethanol or methanol compared to non-polar solvents.
  • Hydrophobic Interactions: The hydrophobic nature of the thiophene groups may lead to limited solubility in water, as they engage in hydrophobic interactions rather than forming favorable interactions with water molecules.
  • Temperature Dependence: Like many organic compounds, its solubility may vary significantly with temperature; elevated temperatures often enhance solubility.

In summary, 3-[bis(2-thienyl)methylene]-1-methyl-piperidine is expected to be soluble in certain polar solvents while being less soluble in water. This solubility behavior emphasizes the importance of solvent choice when working with this compound in synthesis or extraction processes.

Interesting facts

Interesting Facts about 3-[Bis(2-thienyl)methylene]-1-methyl-piperidine

This fascinating chemical compound belongs to the class of piperidine derivatives and features an intricate molecular structure that showcases the rich interplay of organic chemistry. Here are some intriguing aspects of 3-[bis(2-thienyl)methylene]-1-methyl-piperidine:

  • Unique Structure: The compound incorporates two thienyl groups, which are sulfur-containing aromatic rings, making it an interesting subject for studies in medicinal chemistry and organic synthesis.
  • Potential Applications: Compounds like this one are often explored for their biological properties, with some derivatives demonstrating significant activity in anti-cancer and anti-inflammatory research.
  • Electron-Deficient Character: The presence of both nitrogen and sulfur in the structure contributes to its electron deficiency, which can enhance interactions with biological targets, potentially leading to novel therapeutic agents.
  • Synthetic Versatility: Due to its unique chemical functionality, 3-[bis(2-thienyl)methylene]-1-methyl-piperidine can serve as a precursor or intermediate in the synthesis of more complex chemical architectures.
  • Recent Studies: Researchers continue to investigate this compound’s pharmaceutical applications, focusing on its potential roles in molecular recognition and as a scaffold for drug discovery.

In summary, 3-[bis(2-thienyl)methylene]-1-methyl-piperidine not only highlights the beauty of organic chemistry but also opens doors to innovative research avenues in various fields, particularly in medicinal chemistry. Its unique molecular characteristics make it a valuable compound for future scientific exploration.

Synonyms
Tipepidine
5169-78-8
Asverin
Bitiodin
Tipedine
Tipepidina
Tipepidinum
Tipepidine [INN:DCF]
AT 327
Tipepidinum [INN-Latin]
3-(Di-2-thienylmethylene)-1-methylpiperidine
Tipepidina [INN-Spanish]
CR/662
Tipepidine (INN)
UNII-2260ZP67IT
BRN 0212554
CRJ662
DTXSID2022626
2260ZP67IT
TIPEPIDINE [MI]
TIPEPIDINE [INN]
1-Methyl-3-piperidylidenedi(2-thienyl)methane
3-(Di-2-thienylmethylene)-1-methyl-piperidine
AT-327
CR-662
Piperidine, 3-(di-2-thienylmethylene)-1-methyl-
3-(dithiophen-2-ylmethylidene)-1-methylpiperidine
TIPEPIDINE [WHO-DD]
DTXCID402626
Piperidine, 3-(di-2-thienylmethyle)-1-methyl-
4-27-00-06328 (Beilstein Handbook Reference)
NCGC00167424-01
Tipepidinum (INN-Latin)
Tipepidina (INN-Spanish)
3-[bis(thiophen-2-yl)methylidene]-1-methylpiperidine
tipepidine ibenzato
3-(bis(thiophen-2-yl)methylidene)-1-methylpiperidine
Tipepidin
Oprea1_194078
Oprea1_494302
CBDivE_006087
SCHEMBL410090
CHEMBL1899506
R05DB24
CHEBI:135141
Tox21_112428
AKOS000560001
DB13474
DA-68203
CAS-5169-78-8
HY-121685
CS-0083052
NS00122702
3-(di-2-thienylmethylidene)-1-methylpiperidine
D08604
3-(dithiophen-2-ylmethylene)-1-methylpiperidine
EN300-6759842
A852039
Q7808816