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Varenicline

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Identification
Molecular formula
C13H13N3O
CAS number
249296-44-4
IUPAC name
3-(azetidin-2-ylmethoxy)pyridine
State
State

At room temperature, 3-(azetidin-2-ylmethoxy)pyridine is a solid. It is commonly encountered as a crystalline solid that is white to off-white in color. This state assumes ambient conditions of temperature and pressure.

Melting point (Celsius)
223.00
Melting point (Kelvin)
496.15
Boiling point (Celsius)
493.70
Boiling point (Kelvin)
766.85
General information
Molecular weight
211.27g/mol
Molar mass
211.2660g/mol
Density
1.2000g/cm3
Appearence

3-(Azetidin-2-ylmethoxy)pyridine typically appears as a white to off-white crystalline solid. Its solid state form is often powdery, and it may come in various degrees of fineness depending on its preparation and use in research or pharmaceutical formulations.

Comment on solubility

Solubility of 3-(azetidin-2-ylmethoxy)pyridine

The solubility of 3-(azetidin-2-ylmethoxy)pyridine, with the chemical formula C13H13N3O, can be influenced by several factors:

  • Polarity: The presence of the pyridine ring and the azetidine group introduces polarity, which can affect its solubility characteristics.
  • Solvent Type: This compound is likely to be more soluble in polar solvents such as water and alcohols due to the polar functional groups present.
  • Temperature: Generally, an increase in temperature can enhance solubility, making it a crucial aspect when considering this compound.
  • Hydrogen Bonding: The functional groups can participate in hydrogen bonding, which can significantly increase solubility in suitable solvents.

Due to its structural components, it is anticipated that 3-(azetidin-2-ylmethoxy)pyridine will display moderate solubility characteristics. However, the exact solubility in various solvents would require empirical measurements to confirm.

It’s essential to note that compounds with similar structures often exhibit varying degrees of solubility, emphasizing the importance of experimental data to fully understand the behavior of this specific compound in solution.

Interesting facts

Interesting Facts about 3-(azetidin-2-ylmethoxy)pyridine

3-(azetidin-2-ylmethoxy)pyridine is a fascinating compound with diverse applications in medicinal chemistry and organic synthesis. Below are some intriguing aspects of this compound:

  • Structural Significance: This compound contains both a pyridine ring and an azetidine moiety. The combination of these structures allows for unique interactions with various biological targets, making it an excellent candidate for drug development.
  • Biological Activity: Molecules that include pyridine rings are known for their prevalence in natural products and as pharmacophores. The azetidine component has been associated with enhancing the activity of pharmaceutical agents.
  • Synthetic Utility: The methoxy group plays a crucial role in modulating the lipophilicity of the compound, impacting its pharmacokinetic properties. This feature is highly desirable when designing new therapeutic agents.
  • Research Focus: Compounds like 3-(azetidin-2-ylmethoxy)pyridine are often studied for their potential antitumor and antibacterial properties. Researchers are keen on understanding how variations in structure can alter efficacy and selectivity in biological systems.
  • Applications in Drug Design: The strategic incorporation of different substituents on the pyridine and azetidine rings can lead to a library of related compounds, facilitating the optimization of pharmacological properties through structure-activity relationship (SAR) studies.

In summary, 3-(azetidin-2-ylmethoxy)pyridine represents a fascinating area of study within the realm of organic and medicinal chemistry. Its unique structure, potential biological activity, and role in drug discovery underscore its importance in current research. As quoted by a notable chemist, "The beauty of medicinal chemistry lies in the intricate dance between structure and function."

Synonyms
CHEMBL190589
3-(azetidin-2-ylmethoxy)pyridine
SCHEMBL401138
3-(Azetidin-2-ylmethoxy)-pyridine
BDBM50171347