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Amlodipine

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Identification
Molecular formula
C20H25ClN2O5
CAS number
88150-42-9
IUPAC name
3-amino-N-[4-[[2-(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-1-isobutyl-5-phenyl-pentyl]benzamide
State
State

At room temperature, amlodipine is a solid. It is often supplied in its salt form as amlodipine besylate, which is commonly used in tablet formulations for medication.

Melting point (Celsius)
178.00
Melting point (Kelvin)
451.00
Boiling point (Celsius)
302.80
Boiling point (Kelvin)
576.00
General information
Molecular weight
409.49g/mol
Molar mass
409.4900g/mol
Density
1.3850g/cm3
Appearence

Amlodipine is typically found as a white to off-white crystalline powder. It is practically insoluble in water and sparingly soluble in ethanol.

Comment on solubility

Solubility of 3-amino-N-[4-[[2-(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-1-isobutyl-5-phenyl-pentyl]benzamide (C20H25ClN2O5)

Understanding the solubility of 3-amino-N-[4-[[2-(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-1-isobutyl-5-phenyl-pentyl]benzamide is crucial for its application and efficacy in various scientific fields. Here are some key points regarding its solubility:

  • Polar vs. Non-Polar Solvents: Due to its complex structure featuring both polar and non-polar components, this compound is likely soluble in polar solvents like water and methanol, as well as in non-polar solvents such as hexane, though the extent of solubility may vary significantly.
  • Temperature Dependency: The solubility of organic compounds often increases with temperature. Therefore, heating the solvent may enhance the solubility of this compound.
  • Influence of pH: The presence of functional groups such as amino and hydroxyl may lead to ionization, making the solubility dependent on pH. Compounds can become more soluble in a basic environment due to deprotonation.
  • Salt Formation: If the compound interacts with acids or bases, it may form salts that have markedly different solubility characteristics compared to the neutral form.

In summary, the solubility of 3-amino-N-[4-[[2-(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-1-isobutyl-5-phenyl-pentyl]benzamide can be described as multifaceted and highly dependent on several factors such as solvent choice, temperature, and pH. Awareness of these factors is essential for maximizing the compound's utility in applications.

Interesting facts

Interesting Facts About 3-amino-N-[4-[[2-(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-1-isobutyl-5-phenyl-pentyl]benzamide

3-amino-N-[4-[[2-(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-1-isobutyl-5-phenyl-pentyl]benzamide is a fascinating compound with a complex structure and several noteworthy properties:

  • Pharmacological Potential: This compound has garnered attention in medicinal chemistry due to its potential therapeutic applications. It may exhibit properties beneficial for targeting certain diseases, making it a candidate for drug development.
  • Structural Complexity: The compound integrates various functional groups, including amino, hydroxy, and acyl functionalities. This complexity can influence its biological activity and interaction with receptors.
  • Local Anesthetics: Some related compounds in this family are being researched for their effectiveness as local anesthetics, which is essential in pain management and surgical procedures, suggesting that this compound might also have similar potential.
  • Drug Design: The presence of a phenyl ring and dimethylphenoxy unit indicate that the compound may engage in significant π-π stacking interactions, which is crucial in drug-receptor interactions, enhancing binding affinity.
  • Research Relevance: Scientists are illuminating the importance of structural modifications in optimizing drug-like properties. This compound can serve as a model for exploring these modifications in therapeutic settings.

In summary, 3-amino-N-[4-[[2-(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-1-isobutyl-5-phenyl-pentyl]benzamide exemplifies the intricate relationship between structure and function in pharmacy. With ongoing research, it holds promise for future innovations in medicinal chemistry.

Synonyms
SCHEMBL4998034
PD040556