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Pyrazinamide

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Identification
Molecular formula
C5H5N3O
CAS number
98-96-4
IUPAC name
3-amino-6-chloro-N-(diaminomethylene)-5-(dimethylamino)pyrazine-2-carboxamide
State
State

Pyrazinamide is a solid at room temperature. It is generally used in the form of tablets for medical purposes, particularly as an antibacterial medication.

Melting point (Celsius)
190.00
Melting point (Kelvin)
463.15
Boiling point (Celsius)
390.00
Boiling point (Kelvin)
663.15
General information
Molecular weight
123.11g/mol
Molar mass
123.1110g/mol
Density
1.5000g/cm3
Appearence

Pyrazinamide appears as a white crystalline powder. It is practically odorless and has a slightly bitter taste.

Comment on solubility

Solubility of 3-amino-6-chloro-N-(diaminomethylene)-5-(dimethylamino)pyrazine-2-carboxamide

The solubility of 3-amino-6-chloro-N-(diaminomethylene)-5-(dimethylamino)pyrazine-2-carboxamide (C5H5N3O) can be influenced by various factors, including its molecular structure and the presence of functional groups. Understanding its solubility is crucial for its application in chemical processes and formulations. Here are some key points to consider:

  • Polarity: The compound possesses both amino groups and a carboxamide functional group, contributing to increased polarity. This can potentially enhance the solubility in polar solvents, such as water.
  • Hydrogen Bonding: The presence of multiple amino groups may allow for significant hydrogen bonding with solvents, thus improving solubility.
  • Solvent Compatibility: While this compound is likely to be more soluble in aqueous mediums due to its polar nature, it may exhibit variable solubility in organic solvents.

In conclusion, the solubility of 3-amino-6-chloro-N-(diaminomethylene)-5-(dimethylamino)pyrazine-2-carboxamide is expected to be influenced by its polar characteristics and ability to engage in hydrogen bonding. Yet, for precise solubility data, experimental evaluations in different solvents would provide the most accurate insights.

Interesting facts

3-amino-6-chloro-N-(diaminomethylene)-5-(dimethylamino)pyrazine-2-carboxamide

This intriguing compound belongs to the class of pyrazine derivatives, well-known for their diverse biological activities. The structural complexity of 3-amino-6-chloro-N-(diaminomethylene)-5-(dimethylamino)pyrazine-2-carboxamide not only makes it interesting but also emphasizes the importance of functional groups in determining chemical properties and reactivity.

Key Features

  • Pharmacological Potential: Pyrazine derivatives often show promise as pharmaceutical agents. They may exhibit a range of biological functions, including antibacterial, antifungal, or even anticancer activities.
  • Structural Highlights: The inclusion of amino and chloro groups in this molecule contributes to its overall reactivity, making it an interesting subject for synthetic chemists looking to modify or optimize its properties.
  • Interactions: The presence of multiple nitrogen atoms in its structure suggests potential for diverse bonding interactions, such as hydrogen bonding or coordination with metal ions, which may influence its behavior in various solvents or biological systems.

This compound serves as a fascinating example of how modifications to a pyrazine core can lead to new chemical properties and functions. It highlights the importance of exploring and understanding similar derivatives in drug discovery and materials science, making it a prime target for future research.

In conclusion, the exploration of 3-amino-6-chloro-N-(diaminomethylene)-5-(dimethylamino)pyrazine-2-carboxamide not only expands our understanding of pyrazine chemistry but also provides valuable insights for developing novel compounds with significant biological relevance.

Synonyms
5-dimethylamiloride
dimethylamiloride
1214-79-5
dimethyl amylioride
5-(N,N-Dimethyl)amiloride
Dma cpd
5-DMA
5-(N,N-Dimethyl) amiloride
Amiloride, 5-(N,N-Dimethyl)-, hydrochloride
MK 685
MK-685
UNII-3GC547293P
5-(N,N)-Dimethylamiloride
3-Amino-5-dimethylamino-6-chloro-N-(diaminomethylene)pyrazinecarboxamide
3-amino-6-chloro-n-(diaminomethylidene)-5-(dimethylamino)pyrazine-2-carboxamide
CHEMBL465179
DTXSID70923797
Dimethyl amiloride
3GC547293P
2-PYRAZINECARBOXAMIDE, 3-AMINO-N-(AMINOIMINOMETHYL)-6-CHLORO-5-(DIMETHYLAMINO)-
L 591605
L-591605
N,N-DIMETHYLAMILORIDE
Pyrazinecarboxamide, 3-amino-N-(aminoiminomethyl)-6-chloro-5-(dimethylamino)-
Spectrum_001698
3-Amino-5-(N,N-dimethylamino)-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide
SpecPlus_000756
Spectrum2_001615
Spectrum4_001080
Spectrum5_001646
Lopac-A-4562
Lopac0_000017
KBioGR_001440
KBioSS_002178
BIDD:GT0310
DivK1c_006852
SPBio_001649
LT-2
SCHEMBL9852481
KBio1_001796
KBio2_002178
KBio2_004746
KBio2_007314
RXMUPNVSYKGKMY-UHFFFAOYSA-N
DTXCID901352645
BAA21479
BDBM50485565
EX-A10488
CCG-204113
SDCCGSBI-0050006.P003
NCGC00015059-01
NCGC00015059-02
NCGC00015059-03
NCGC00015059-05
NCGC00162045-01
DA-60391
PD034519
HY-138866
CS-0169666
G77813
Q27257185
N-(3-Amino-6-chloro-5-dimethylamino-pyrazine-2-carbonyl)-guanidine
3-amino-N-carbamimidoyl-6-chloro-5-(dimethylamino)pyrazine-2-carboxamide