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Paclitaxel

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Identification
Molecular formula
C47H51NO14
CAS number
33069-62-4
IUPAC name
[3-acetoxy-6-[formyl(methyl)amino]-1-[5-(16-hydroxy-10,22-dimethoxy-11,21-dimethyl-12,18-dioxo-3,7,19,27-tetraoxa-29,30,31-triazatetracyclo[24.2.1.12,5.16,9]hentriaconta-1(28),2(31),4,6(30),8,13,24,26(29)-octaen-20-yl)-4-methoxy-3-methyl-pentyl]-2,4-dimethyl-hex-5-enyl] 2,3-dimethoxypropanoate
State
State

At room temperature, Paclitaxel is typically found as a solid crystalline powder. It is hydrophobic and not readily dissolvable in water, necessitating specific solvents for administration as a medication.

Melting point (Celsius)
213.00
Melting point (Kelvin)
486.20
Boiling point (Celsius)
961.40
Boiling point (Kelvin)
1 234.60
General information
Molecular weight
853.91g/mol
Molar mass
853.9070g/mol
Density
1.4320g/cm3
Appearence

Paclitaxel appears as a white to off-white crystalline powder. It is not soluble in water, making it necessary to dissolve it in suitable diluents for pharmaceutical use. The compound is known for its ability to be used as an injectable for cancer treatment, hence it is often seen in the form of a liquid solution.

Comment on solubility

Solubility of 3-acetoxy-6-[formyl(methyl)amino]-1-[5-(16-hydroxy-10,22-dimethoxy-11,21-dimethyl-12,18-dioxo-3,7,19,27-tetraoxa-29,30,31-triazatetracyclo[24.2.1.12,5.16,9]hentriaconta-1(28),2(31),4,6(30),8,13,24,26(29)-octaen-20-yl)-4-methoxy-3-methyl-pentyl]-2,4-dimethyl-hex-5-enyl] 2,3-dimethoxypropanoate

The solubility of a compound can significantly influence its chemical behavior and practical applications. In the case of the compound with the formula C47H51NO14, the following points are pertinent:

  • Polarity: Given the presence of functional groups such as acetoxy and dimethoxy, this compound is likely to have polar characteristics, which could enhance its solubility in polar solvents like water.
  • Size and Structure: The large molecular structure can impede solubility in some less polar solvents, affecting how it interacts with various chemical environments.
  • Hydrogen Bonding: The ability to form hydrogen bonds due to hydroxyl or ether groups may facilitate solubility in alcohols and other similar organic solvents.
  • Solvent Dependency: The overall solubility could vary drastically based on the solvent, demonstrating a potential for better solubility in organic solvents versus aqueous solutions.

In conclusion, understanding the solubility of this complex compound is essential for predicting its behavior in various chemical reactions and potential applications. As is often the case in chemistry, solubility can be a decisive factor in the success of utilizing this compound in real-world scenarios.

Interesting facts

Interesting Facts about 3-acetoxy-6-[formyl(methyl)amino]-1-[5-(16-hydroxy-10,22-dimethoxy-11,21-dimethyl-12,18-dioxo-3,7,19,27-tetraoxa-29,30,31-triazatetracyclo[24.2.1.12,5.16,9]hentriaconta-1(28),2(31),4,6(30),8,13,24,26(29)-octaen-20-yl)-4-methoxy-3-methyl-pentyl]-2,4-dimethyl-hex-5-enyl] 2,3-dimethoxypropanoate

This remarkable compound showcases the intricate complexity of organic chemistry. Here are some compelling characteristics:

  • Structural Complexity: The name itself suggests a highly intricate structure, reflecting a rich tapestry of chemical functionalities.
  • Applications: Compounds with such elaborate structures are often researched for potential applications in pharmaceuticals, particularly in drug development for complex diseases.
  • Active Ingredients: This compound may serve as an active ingredient in various formulations, hinting at its potential biological activity.
  • Research Interest: Given its elaborate carbon skeleton and functional groups, it is a prime candidate for studies in medicinal chemistry and bioactivity.

As a chemistry student or researcher, one can appreciate the depth of study required to synthesize and analyze such compounds. The variation in functionalities brings about opportunities to explore interactions at the molecular level. It is essential to note that compounds of this nature often inspire discussions around their synthesis, mechanism of action, and potential for innovation in drug discovery.

As phrased by a seasoned chemist, "The beauty of organic chemistry lies not just in the compounds themselves, but in the stories they tell of nature's ingenuity."

In summary, studying complex compounds like this one provides rich educational experiences and paves the way for advancements in various scientific fields.

Synonyms
mycalolide b
Mycalolide-B
122752-21-0
CHEBI:177640
[4-acetyloxy-1-[ormyl(methyl)amino]-11-(16-hydroxy-10,22-dimethoxy-11,21-dimethyl-12,18-dioxo-3,7,19,27-tetraoxa-29,30,31-triazatetracyclo[24.2.1.12,5.16,9]hentriaconta-1(28),2(31),4,6(30),8,13,24,26(29)-octaen-20-yl)-10-methoxy-3,5,9-trimethylundec-1-en-6-yl] 2,3-dimethoxypropanoate