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Staurosporine

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Identification
Molecular formula
C28H26N4O3
CAS number
62996-74-1
IUPAC name
3-[8-[(dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dione
State
State

At room temperature, staurosporine is typically found in a solid state as a powder.

Melting point (Celsius)
219.00
Melting point (Kelvin)
492.15
Boiling point (Celsius)
280.00
Boiling point (Kelvin)
553.15
General information
Molecular weight
466.54g/mol
Molar mass
466.5390g/mol
Density
1.2765g/cm3
Appearence

Staurosporine typically appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of 3-[8-[(dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dione

The solubility of the compound C28H26N4O3 can be influenced by a variety of factors. Here are some key considerations:

  • Polarity: This compound contains both hydrophilic (water-attracting) and hydrophobic (water-repelling) regions due to its complex structure. The presence of multiple nitrogen atoms in the form of dimethylamino and pyrrole contributes to its potential water solubility, making it somewhat polar.
  • Solvent Interaction: The solubility may vary significantly depending on the solvent used. For instance, it could show better solubility in organic solvents (such as dimethyl sulfoxide or ethanol) compared to water.
  • Temperature Effects: Generally, solubility can increase with temperature; thus, higher temperatures might enhance the dissolving process in a suitable solvent.
  • pH of the Solution: The compound may also show variable solubility across different pH levels, as certain functional groups can become protonated or deprotonated, leading to altered solubility.

In conclusion, while the precise solubility characteristics may require experimental determination, understanding the interplay of polarity, solvent interactions, temperature, and pH is critical in predicting the behavior of this chemical compound in various environments.

Interesting facts

Interesting Facts about 3-[8-[(dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dione

This compound, with a complex structure, belongs to the class of pyrrole derivatives, which are known for their significant biological activities. It's fascinating to observe how the intricate arrangement of atoms can influence the properties and applications of such compounds. Here are some intriguing aspects:

  • Diverse Applications: Pyrrole derivatives, like this compound, often exhibit a range of pharmacological activities, making them valuable in medicinal chemistry.
  • Structure-Activity Relationship (SAR): The presence of functional groups, such as the dimethylamino moiety, significantly alters the reactivity and interaction of the molecule with biological targets.
  • Novel Therapeutics: Compounds with similar structures are being investigated for their potential use as therapeutic agents in neuropharmacology, particularly against neurological disorders.
  • Indole Connection: The indole rings present in the structure are common in many natural products and pharmaceutical agents, often known for their role in serotonin receptor modulation.
  • Research Interest: The ongoing research into compounds with such sophisticated frameworks could lead to the development of new drugs that are both potent and selective.

In summary, this compound showcases the beauty of chemical architecture and its profound impact on biological systems. As research progresses, we may uncover even more about the mechanisms of action and therapeutic potential inherent in these remarkable structures.

Synonyms
131848-98-1
Ro 31-8830
Ro-31-8830
Bisindolylmaleimide deriv. 18b
3-(8-((Dimethylamino)methyl)-6,7,8,9-tetrahydropyrido(1,2-a)indol-10-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
3-[8-[(dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dione
1H-Pyrrole-2,5-dione, 3-[8-[(dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-
1H-Pyrrole-2,5-dione, 3-(8-((dimethylamino)methyl)-6,7,8,9-tetrahydropyrido(1,2-a)indol-10-yl)-4-(1-methyl-1H-indol-3-yl)-
3-[8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Bisindolylmaleimide XI
BIM-XI
BIM11
RKX867S6TK
CHEMBL95925
BDBM2705
SCHEMBL5036866
DTXSID20927366
HMS3401G14
HMS3401J16
EX-A11216
HSCI1_000347
NSC767270
AKOS040749339
BIM 11; Bisindolylmaleimide XI, HCl
NSC-767270
Ro31-8830
SDCCGRCH-0000100.P001
NCGC00163696-01
NCGC00163696-04
HY-117610
K00206
3-[8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione Hydrochloride
3-{2-[(dimethylamino)methyl]-1H,2H,3H,4H-pyrido[1,2-a]indol-10-yl}-4-(1-methyl-1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione
3-{8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl}-5-hydroxy-4-(1-methyl-1H-indol-3-yl)-2H-pyrrol-2-one