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Amoxapine

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Identification
Molecular formula
C17H18ClN3O
CAS number
14028-44-5
IUPAC name
3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethyl-propan-1-amine
State
State

Amoxapine is a solid at room temperature. It is often available in crystalline form as a pharmaceutical compound.

Melting point (Celsius)
209.00
Melting point (Kelvin)
482.15
Boiling point (Celsius)
267.00
Boiling point (Kelvin)
540.15
General information
Molecular weight
313.41g/mol
Molar mass
313.4140g/mol
Density
0.2204g/cm3
Appearence

Amoxapine typically appears as a white to off-white crystalline powder. It is practically insoluble in water but soluble in organic solvents like DMSO.

Comment on solubility

Solubility of 3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethyl-propan-1-amine

The solubility of the compound 3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethyl-propan-1-amine, with the chemical formula C17H18ClN3O, can be influenced by several factors due to its complex structure. Understanding solubility is essential for various applications in chemistry, pharmacology, and material science. Here are some key points regarding its solubility:

  • Polarity: The presence of polar functional groups can enhance solubility in polar solvents and reduce solubility in non-polar solvents.
  • Hydrogen Bonding: Compounds capable of hydrogen bonding often exhibit increased solubility in water. If this compound can participate in hydrogen bonding, it may dissolve in aqueous solutions.
  • Temperature Effect: As temperature increases, solubility often increases for many solids; thus, testing solubility at different temperatures may provide insights.
  • pH Dependency: The solubility of ionic compounds can be affected by the pH of the solution, making it crucial to consider the environment in which the compound is tested.

In conclusion, although specific solubility data may not be readily available for this compound, its unique structural characteristics suggest potential variability in solubility based on the above factors. Understanding these solubility parameters can aid in predicting the behavior of the compound in different chemical environments.

Interesting facts

Interesting Facts About 3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethyl-propan-1-amine

3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethyl-propan-1-amine is a fascinating compound within the realm of organic chemistry. This compound possesses unique structural characteristics that make it noteworthy for several reasons:

  • Complex Structure: The compound features a complex bicyclic structure, specifically a fusion of benzene and oxepine rings, which contributes to its interesting chemical properties and potential reactivity.
  • Biological Activity: Compounds related to benzoxepins are often studied for their biological activities. They may exhibit antidepressant, anxiolytic, or antipsychotic effects, making them important in pharmacological research.
  • Synthetic Pathways: The synthesis of this compound can be a challenging but rewarding endeavor. It often involves multistep reactions, making it a valuable example for students learning about synthetic organic chemistry.
  • Chemical Versatility: Due to the presence of amine and ylidene functional groups, this compound can potentially undergo a variety of chemical reactions, such as nucleophilic additions or substitutions. This versatility allows for further functionalization, which is crucial in drug design.

As a chemical scientist or student, one might find it intriguing to explore how slight modifications to the structure of 3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethyl-propan-1-amine can lead to compounds with vastly different properties and effects.

In the words of a renowned chemist, "The beauty of chemistry lies in the intricate dance of atoms and molecules, where small changes can have profound implications." This compound exemplifies that philosophy, showcasing the potential of molecular design in creating targeted therapeutic agents.

Synonyms
doxepin
1668-19-5
Zonalon
Sinequan
Doxepine
3-(Dibenzo[b,e]oxepin-11(6H)-ylidene)-N,N-dimethylpropan-1-amine
CHEBI:4710
1-Propanamine, 3-dibenz[b,e]oxepin-11(6H)-ylidene-N,N-dimethyl-
(E)-Doxepin-d3
1-Propanamine, 3-dibenz(b,e)oxepin-11(6H)-ylidene-N,N-dimethyl-
DTXSID7022966
Sinepin
NSC 108160
Cidoxepin (free base)
Spectrum_000805
Prestwick0_000263
Prestwick1_000263
Spectrum2_000133
Spectrum3_000407
Spectrum4_000526
Oprea1_473232
SCHEMBL28054
KBioGR_001131
KBioSS_001285
DivK1c_000431
SPBio_000206
SPBio_002325
(E)-3-(Dibenzo[b,e]oxepin-11(6H)-ylidene)-N,N-dimethylpropan-1-amine
(Z)-3-(dibenzo[b,e]oxepin-11(6H)-ylidene)-N,N-dimethylpropan-1-amine
CHEMBL1628227
KBio1_000431
KBio2_001285
KBio2_003853
KBio2_006421
KBio3_001154
NINDS_000431
DAA60734
3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethylpropan-1-amine
BDBM50225488
AKOS028110197
NCGC00015344-05
G78292
11-(3-dimethylamino-propylidene)-6,11-dihydrodibenzo-[b,e]-oxepine
3-(6,11-Dihydrodibenz[b,e]oxepin-11-yliden)-N,N-dimethylpropylamin
(3Z)-3-(Dibenzo[b,e]Oxepin-11(6H)-Ylidene)-N,N-Dimethyl-1-Propanamine
11-(3-dimethylamino-propylidene)- 6,11-dihydrodibenzo- [b,e]-oxepine
DIMETHYL(3-{9-OXATRICYCLO[9.4.0.0(3),?]PENTADECA-1(11),3,5,7,12,14-HEXAEN-2-YLIDENE}PROPYL)AMINE