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3-(5-fluoro-1H-indol-3-yl)propyl dihydrogen phosphate

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Identification
Molecular formula
C11H13FN2O3P
CAS number
183654-48-6
IUPAC name
3-(5-fluoro-1H-indol-3-yl)propyl dihydrogen phosphate
State
State

This compound is generally in a solid state at room temperature.

Melting point (Celsius)
107.00
Melting point (Kelvin)
380.15
Boiling point (Celsius)
275.00
Boiling point (Kelvin)
548.00
General information
Molecular weight
287.22g/mol
Molar mass
287.2210g/mol
Density
1.4600g/cm3
Appearence

3-(5-Fluoro-1H-indol-3-yl)propyl dihydrogen phosphate is typically a white to off-white crystalline solid. It may also appear as a fine powder, depending on its preparation and storage conditions.

Comment on solubility

Solubility of 3-(5-fluoro-1H-indol-3-yl)propyl dihydrogen phosphate

The solubility of 3-(5-fluoro-1H-indol-3-yl)propyl dihydrogen phosphate (C11H13FN2O3P) can be influenced by several factors, making it a fascinating compound to study in this regard. Here are some key points to consider:

  • Polar Functional Groups: The presence of dihydrogen phosphate groups typically enhances water solubility due to their strong hydrogen bonding capabilities.
  • Indole Moiety: The indole ring can introduce hydrophobic characteristics, which may reduce overall solubility in polar solvents.
  • Effect of Fluorine: The fluorine atom can affect both polarity and stability, potentially influencing the compound's solubility in organic solvents.
  • pH Sensitivity: As a phosphate compound, its solubility may vary significantly with changes in pH, highlighting the importance of environmental conditions.

In conclusion, the solubility of this compound is likely to be moderate in aqueous solutions and could exhibit different behaviors in organic solvents based on the interactions mentioned. Understanding the balance of hydrophilic and hydrophobic components in its structure is crucial when predicting its solubility profile.

Interesting facts

Interesting Facts about 3-(5-fluoro-1H-indol-3-yl)propyl dihydrogen phosphate

3-(5-fluoro-1H-indol-3-yl)propyl dihydrogen phosphate is a fascinating compound that combines the grace of indole chemistry with the versatility of phosphates. This compound is notable for several reasons:

  • Biological Relevance: The indole core is a common structure in many biologically active molecules, which makes this compound of interest for pharmacology and medicinal chemistry.
  • Fluorine Substitution: The presence of a fluorine atom not only enhances the lipophilicity of the compound but can also influence its biological activity, making fluorinated compounds significant in drug design.
  • Phosphorylation: The dihydrogen phosphate group introduces the potential for this compound to participate in phosphorylation reactions, which are vital in biochemical pathways, including signal transduction and enzyme regulation.
  • Potential Therapeutic Applications: Given its unique structure, it may exhibit properties that can be leveraged in developing treatments for conditions affected by indole-based compounds, like cancer or neurodegenerative disorders.

In summary, 3-(5-fluoro-1H-indol-3-yl)propyl dihydrogen phosphate presents a blend of *chemical properties* and *biological activities* that could open avenues for new research. With its potential to influence various pathways through its indole and phosphate functionalities, it certainly holds a captivating place in the realm of chemical compounds.

As the renowned chemist Friedrich August Kekulé once said, “The more I study, the more I am amazed at the blessings of chemistry.” This compound is a splendid example of such blessings.

Synonyms
5-fluoroindole propanol phosphate
(3-(5-fluoro-1H-indol-3-yl)propoxy)phosphonic acid
[3-(5-fluoro-1H-indol-3-yl)propoxy]phosphonic acid
3-(5-fluoro-1H-indol-3-yl)propyl dihydrogen phosphate
CHEMBL1160523
DB07773
PD005477
NS00069149
Q27096992