3-(4-Methoxyphenyl)sulfonyltetralin-2-carbohydroxamic acid

Identification

Molecular formula

C₁₇H₁₇NO₅S

CAS number

1047704-64-2

IUPAC name

3-(4-methoxyphenyl)sulfonyltetralin-2-carbohydroxamic acid

State

At room temperature, 3-(4-Methoxyphenyl)sulfonyltetralin-2-carbohydroxamic acid is typically a solid. It retains its structure under standard conditions and is stable in its crystalline form.

Melting point (Celsius)

210.00

Melting point (Kelvin)

483.15

Boiling point (Celsius)

315.00

Boiling point (Kelvin)

588.15

General information

Molecular weight

337.36g/mol

Molar mass

337.3600g/mol

Density

1.2810g/cm³

Appearence

3-(4-Methoxyphenyl)sulfonyltetralin-2-carbohydroxamic acid is generally a white to off-white crystalline solid. The compound may appear as small crystals or powder, with its exact appearance depending upon the specific conditions of crystallization.

Comment on solubility

Solubility of 3-(4-methoxyphenyl)sulfonyltetralin-2-carbohydroxamic acid

The solubility of the compound 3-(4-methoxyphenyl)sulfonyltetralin-2-carbohydroxamic acid (C₁₇H₁₇NO₅S) is an essential factor to consider in various applications, particularly in medicinal chemistry and pharmacology. This compound's solubility characteristics are heavily influenced by its molecular structure, which includes both hydrophobic and hydrophilic components.

Key factors affecting its solubility include:

Polarity: The presence of hydroxamic acid functional groups contributes to higher solubility in polar solvents like water.
Hydrophobic regions: The methoxy group and sulfonyl moiety may decrease solubility in non-polar solvents, indicating a dual nature.
Temperature: Increased temperature generally enhances the solubility of organic compounds, and this may also apply to this specific compound.

In general, compounds like 3-(4-methoxyphenyl)sulfonyltetralin-2-carbohydroxamic acid may exhibit:

Moderate solubility in aqueous solutions due to their functional groups.
Increased solubility in organic solvents because of hydrophobic interactions.

Understanding the solubility of this compound is crucial for predicting its behavior in biological systems and formulations. As one delves deeper into its solubility properties, further studies are likely needed to comprehensively understand its interactions with various solvents and environments.

Interesting facts

Exploring 3-(4-methoxyphenyl)sulfonyltetralin-2-carbohydroxamic Acid

The compound 3-(4-methoxyphenyl)sulfonyltetralin-2-carbohydroxamic acid is a fascinating example of an organic molecule that showcases the intersection of aromatic chemistry and biological activity. This compound is derived from tetralin, which contributes a bicyclic structure, and is modified with a sulfonyl group and a hydroxamic acid functional moiety, making it of interest in medicinal chemistry.

Key Features and Applications:

Versatile Functional Group: The presence of the hydroxamic acid group is notable; these compounds are often associated with various biological activities, including inhibition of metalloproteinases, which play a critical role in tissue remodeling and disease progression.
Aromatic Influence: The 4-methoxyphenyl group enhances the compound's solubility and can influence its pharmacokinetic properties, making it more effective when developed for therapeutic applications.
Potential Therapeutic Use: Research indicates that compounds with similar structures may show promise in treating conditions like cancer and inflammatory disorders due to their ability to modulate biological pathways.
Chirality and Isomerism: The stereochemistry around the tetralin structure offers opportunities for creating enantiomerically pure compounds that could exhibit different biological profiles—it’s a prime focus area for asymmetric synthesis in drug development.

As stated by leading chemists, "the intricate balance between structure and function is what defines the potential of organic compounds in therapeutic settings." Understanding the nuances of compounds like 3-(4-methoxyphenyl)sulfonyltetralin-2-carbohydroxamic acid not only broadens our chemical knowledge but also paves the way for innovative drug design.

In conclusion, this compound embodies the versatility and complexity found in modern organic chemistry. Continued research could unveil further applications and enhance our understanding of how minor structural changes can lead to significant differences in biological activity.