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4-Hydroxyphenylpyruvic acid

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Identification
Molecular formula
C9H8O4
CAS number
156-39-8
IUPAC name
3-(4-hydroxyphenyl)-2-oxo-propanoic acid
State
State
At room temperature, 4-Hydroxyphenylpyruvic acid is in a solid state. It remains stable under normal conditions and is accessible in laboratory environments for chemical reactions and studies.
Melting point (Celsius)
157.00
Melting point (Kelvin)
430.15
Boiling point (Celsius)
350.00
Boiling point (Kelvin)
623.15
General information
Molecular weight
180.16g/mol
Molar mass
180.1570g/mol
Density
1.3661g/cm3
Appearence

4-Hydroxyphenylpyruvic acid appears as a white to off-white crystalline solid. It is typically a powder form and is visually characterized by its fine nature without any significant impurities visible to the naked eye.

Comment on solubility

Solubility of 3-(4-hydroxyphenyl)-2-oxo-propanoic acid

The solubility of 3-(4-hydroxyphenyl)-2-oxo-propanoic acid (C9H8O4) is an intriguing aspect of this compound that merits attention. This organic acid, characterized by its phenolic structure, exhibits some notable solubility traits:

  • Water Solubility: This compound is moderately soluble in water due to the presence of the hydroxy (–OH) group, which can form hydrogen bonds with water molecules, enhancing its solubility.
  • Solvent Interactions: In organic solvents, such as ethanol or methanol, 3-(4-hydroxyphenyl)-2-oxo-propanoic acid tends to be more soluble, reflecting its non-polar characteristics due to the aromatic ring.
  • pH Dependent Solubility: The solubility can be influenced by the pH of the solution; it is generally more soluble in alkaline conditions where it can exist predominantly in its anionic form.

In summary, while the solubility of this compound in water is limited, its behavior in different solvents and under varying pH conditions illustrates the complexity of its chemical interactions. Understanding these solubility dynamics is essential for its applications in medicinal chemistry and other fields.


Interesting facts

Interesting Facts about 3-(4-Hydroxyphenyl)-2-oxo-propanoic Acid

3-(4-hydroxyphenyl)-2-oxo-propanoic acid, also known as Phenylpyruvic acid, is a fascinating compound that plays a notable role in biochemistry and medicinal chemistry. Here are some key points to consider:

  • Metabolic Importance: This compound is implicated in the metabolic pathway of the amino acid phenylalanine, pointing towards its significance in understanding metabolic disorders such as phenylketonuria (PKU).
  • Biological Activity: 3-(4-hydroxyphenyl)-2-oxo-propanoic acid exhibits intriguing biological properties, which may include antioxidant activities that are beneficial in various physiological processes.
  • Research Applications: The compound serves as a substrate for various enzymatic reactions, making it a valuable tool in biochemical research. Its ability to participate in reactions involving phenolic compounds can aid in the study of drug design and development.
  • Natural Occurrence: It has been found in certain plants and can relate to the biosynthesis of various natural products, showing how nature utilizes this compound in metabolic processes.
  • Potential Therapeutic Roles: Due to its structure, researchers are exploring its potential use in the development of pharmaceuticals aimed at treating metabolic conditions closely related to amino acid catabolism.

In summary, the compound 3-(4-hydroxyphenyl)-2-oxo-propanoic acid is not merely a chemical formula on a page; it represents a critical intersection of nutrition, metabolism, and medicinal chemistry. It emphasizes the importance of understanding metabolites for advancements in health sciences.

Synonyms
4-Hydroxyphenylpyruvic acid
156-39-8
3-(4-Hydroxyphenyl)-2-oxopropanoic acid
Testacid
4-hydroxyphenylpyruvate
p-Hydroxyphenylpyruvic acid
3-(4-Hydroxyphenyl)pyruvic acid
Testacide
(P-HYDROXYPHENYL)PYRUVIC ACID
3-(p-Hydroxyphenyl)pyruvic acid
(4-hydroxyphenyl)pyruvic acid
3-(p-Hydroxyphenyl)-2-oxopropanoic acid
p-hydroxyphenylpyruvate
3-(4-HYDROXY-PHENYL)PYRUVIC ACID
(p-hydroxyphenyl)-pyruvic acid
Pyruvic acid, p-hydroxyphenyl-
NSC 100738
Pyruvic acid, (p-hydroxyphenyl)-
4-Hydroxy alpha-oxobenzenepropanoic acid
HPPA
Benzenepropanoic acid, 4-hydroxy-alpha-oxo-
BRN 2691632
3-(4-Hydroxyphenyl)pyruvate
4-Hydroxy-a-oxobenzenepropanoic acid
EINECS 205-852-9
UNII-0YP1694WNQ
MFCD00002591
p-hydroxyphenylpyruvic
CHEBI:15999
3-(4-hydroxyphenyl)-2-oxo-propanoic acid
4HPPA
4-Hydroxy-Phenylpyruvate
(p-Hydroxyphenyl)pyruvate
Benzenepropanoic acid, 4-hydroxy-.alpha.-oxo-
(p-hydroxyphenyl)-Pyruvate
4-HPPA
NSC-100738
NSC-666757
4-?Hydroxyphenylpyruvic acid
3-(p-Hydroxyphenyl)-2-oxopropionic acid
3-(4-Hydroxyphenyl)-2-oxopropionic acid
0YP1694WNQ
4-Hydroxy-a-oxobenzenepropanoate
DTXSID80166017
4-10-00-03630 (Beilstein Handbook Reference)
4-Hydroxy-alpha-oxobenzenepropanoate
3-(p-Hydroxyphenyl)-2-oxopropionate
NSC666757
3-(4-Hydroxyphenyl)-2-oxopropionate
3-(4-hydroxyphenyl)-2-oxo-propanoate
4-Hydroxy-alpha-oxobenzenepropanoic acid
hydroxyphenylpyruvate
Benzenepropanoic acid, 4-hydroxy-alpha-oxo- (9CI)
(4-hydroxyphenyl)pyruvate
3-(p-Hydroxyphenyl)pyruvate
ENO
para-hydroxyphenylpyruvic acid
4-ydroxyphenylpyruvic acid
WLN: QVV1R DQ
bmse000262
4- Hydroxyphenylpyruvic acid
SCHEMBL24157
3-(4-hydroxy-phenyl)pyruvate
CHEMBL607712
GTPL6629
4-Hydroxy a-oxobenzenepropanoate
DTXCID9088508
4-Hydroxyphenylpyruvic acid, 98%
4-Hydroxy I+--oxobenzenepropanoate
STR05283
4-Hydroxy a-oxobenzenepropanoic acid
4-Hydroxy alpha-oxobenzenepropanoate
3-(p-Hydroxyphenyl)-2-oxopropanoate
BBL104224
GEO-01551
NSC100738
s2995
STL558218
AKOS000136920
4-Hydroxy I+--oxobenzenepropanoic acid
AC-7498
CS-W010756
DB07718
FD10465
FH37633
HY-W010040
NSC 666757
3-(4-Hydroxyphenyl)-2-oxopropanoicacid
Benzenepropanoic acid, ?-hydroxy-?-oxo-
p-Hydroxyphenyl-brenztraubensA currencyure
PD005526
Pyruvic acid, (p-hydroxyphenyl)- (8CI)
SY050624
3-(4-hydroxyphenyl)-2-oxo-propionic acid
3-(4-hydroxy phenyl)-2-oxo propanoic acid
3-(4-Hydroxyphenyl)-2-oxopropanoic acid #
NS00015136
C01179
EN300-1855716
4-HYDROXY-.ALPHA.-OXOBENZENEPROPANOIC ACID
Q2823224
87E988C4-F26C-4E03-9A40-1B0C0B36CA67
4-Hydroxyphenylpyruvic acid, Grade II, 98-100%, crystalline
(p-Hydroxyphenyl)pyruvic Acid; 3-(4-Hydroxyphenyl)-2-oxopropanoic Acid;
3-(4-Hydroxyphenyl)-2-oxopropionic Acid; 3-(4-Hydroxyphenyl)pyruvic Acid;
3-(p-Hydroxyphenyl)-2-oxopropionic Acid; 3-(p-Hydroxyphenyl)pyruvic Acid;
4-Hydroxy-a-oxobenzenepropanoic Acid; HPPA; NSC 100738; NSC 666757;