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Didanosine

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Identification
Molecular formula
C10H12N4O3
CAS number
69655-05-6
IUPAC name
3-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-7,8-dihydro-4H-imidazo[4,5-d][1,3]diazepin-8-ol
State
State

At room temperature, didanosine is in a solid state, typically appearing as a powder, making it suitable for formulation into tablets or capsules for medicinal use.

Melting point (Celsius)
172.00
Melting point (Kelvin)
445.15
Boiling point (Celsius)
157.00
Boiling point (Kelvin)
430.15
General information
Molecular weight
236.23g/mol
Molar mass
236.2340g/mol
Density
1.6600g/cm3
Appearence

Didanosine typically appears as a white, crystalline powder. It is slightly hygroscopic and may absorb moisture when exposed to air. The compound is usually marketed in formulations suitable for oral administration.

Comment on solubility

Solubility of 3-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-7,8-dihydro-4H-imidazo[4,5-d][1,3]diazepin-8-ol

The solubility of the compound 3-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-7,8-dihydro-4H-imidazo[4,5-d][1,3]diazepin-8-ol (C10H12N4O3) can be influenced by several factors due to its structural complexity and functional groups present.

Solubility characteristics:

  • Polarity: The presence of hydroxyl groups typically increases polarity, which can enhance solubility in polar solvents such as water.
  • Hydrogen bonding: This compound can engage in significant hydrogen bonding owing to its multiple hydroxyl functional groups, potentially promoting solubility in aqueous environments.
  • Solvent Effects: While it may exhibit solubility in water, variations in temperature and pH can also affect its solubility profile.
  • Organic solvents: Depending on the presence of hydrophobic regions, it may also be soluble in some organic solvents, albeit to a lesser extent compared to its solubility in water.

In practical applications, understanding the solubility of this compound is crucial as high solubility can be advantageous in pharmaceutical formulations where rapid dissolution is required for bioavailability. On the other hand, poor solubility may pose challenges that necessitate the use of solubility enhancers or the development of specialized formulations.

Interesting facts

Interesting Facts About 3-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-7,8-dihydro-4H-imidazo[4,5-d][1,3]diazepin-8-ol

This fascinating compound is a part of a larger family of imidazo[4,5-d][1,3]diazepines, which are known for their diverse applications in medicinal chemistry. Here are some notable aspects of this compound:

  • Structure and Function: The compound exhibits a unique structural arrangement that combines a tetrahydrofuran moiety with an imidazodiazepine framework, contributing to its potential biological activity. Its specific arrangement of functional groups may influence its interaction with biological targets, making it of interest for drug development.

  • Biological Relevance: Compounds like these are often investigated for their therapeutic implications. There is a possibility of them acting as anxiolytics, hypnotics, or anticonvulsants due to their interaction with the GABA receptor systems in the brain.

  • Synthetic Pathways: The synthesis of this compound involves intricate organic reactions, showcasing the beauty of organic chemistry in constructing complex molecules. The presence of hydroxyl groups in its structure highlights the role of stereochemistry in pharmaceutical activity.

  • Potential Research Applications: Due to its novelty, ongoing research might reveal additional pharmacological properties, making it an exciting subject for further study in the field of drug discovery.

In considering this compound, one cannot ignore the words of renowned chemists who emphasize the importance of understanding molecular connections: "The beauty of a molecule lies not only in its structure but in its capacity to interact dynamically with biological systems."

With its intricate composition, this compound not only represents a step towards greater knowledge in organic chemistry but also holds the potential to contribute significantly to advancements in human health.

Synonyms
53910-25-1
2'-Deoxycoformycin
Vidarbine
CO-Vidarabine
Co-V
Deaminase inhibitor (PD)
Vira A deaminase inhibitor
Deaminase inhibitor
2'-Dexoycoformycin
NSC 218321
CI-825;Deoxycoformycin
CL 67310465
dCF
SCHEMBL14031902
DTXSID00860661
FPVKHBSQESCIEP-UHFFFAOYSA-N
HMS3870I13
Imidazo(4,5-d)(1,3)diazepin-8-ol, 3-(2-deoxy-.beta.-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydro-, (R)-
PB12063
3-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-7,8-dihydro-4H-imidazo[4,5-d][1,3]diazepin-8-ol
LS-13984
EN300-297506
3-(2-Deoxypentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol
(8R)-3-[(4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-7,8-dihydro-4H-imidazo[4,5-d][1,3]diazepin-8-ol
3-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H,6H,7H,8H-imidazo[4,5-d][1,3]diazepin-8-ol