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Clomipramine

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Identification
Molecular formula
C19H23ClN2
CAS number
303-49-1
IUPAC name
3-(4-chlorophenyl)-N,N-dimethyl-3-(2-pyridyl)propan-1-amine
State
State

At room temperature, clomipramine is typically found in a solid state as a crystalline powder. It is stable under normal conditions when stored and handled properly.

Melting point (Celsius)
192.00
Melting point (Kelvin)
465.15
Boiling point (Celsius)
452.50
Boiling point (Kelvin)
725.65
General information
Molecular weight
314.86g/mol
Molar mass
314.8640g/mol
Density
1.1800g/cm3
Appearence

Clomipramine is a white to off-white crystalline powder. It is practically insoluble in water, soluble in acetone, and very soluble in chloroform. The powder can exhibit a slight odor that is not pungent.

Comment on solubility

Solubility of 3-(4-chlorophenyl)-N,N-dimethyl-3-(2-pyridyl)propan-1-amine

The solubility of the compound C19H23ClN2, also known as 3-(4-chlorophenyl)-N,N-dimethyl-3-(2-pyridyl)propan-1-amine, can be influenced by various factors due to its chemical structure and functional groups.

Key Points Regarding Solubility:

  • Nonpolar Nature: The presence of large hydrophobic phenyl and pyridine rings contributes to lower solubility in polar solvents like water.
  • Solvent Polarity: This compound is more likely to dissolve in organic solvents such as ethanol, acetone, or chloroform due to its nonpolar characteristics.
  • Temperature Effects: Increased temperature typically enhances the solubility of solid compounds in liquids, which could be beneficial for this molecule.
  • Amine Group: The presence of the amine functional group may allow for some interaction with water molecules, potentially leading to limited solubility.

In summary, while C19H23ClN2 possesses some structural components that may interact favorably with polar solvents, its overall hydrophobic nature could restrict solubility in aqueous environments. As with many organic compounds, solubility behavior is complex and can vary significantly based on the specific conditions used during experimentation.

Interesting facts

Interesting Facts about 3-(4-chlorophenyl)-N,N-dimethyl-3-(2-pyridyl)propan-1-amine

This compound, often referred to in the realm of medicinal chemistry, is known for its intriguing structure and properties. Its framework includes both an aromatic chlorophenyl group and a pyridyl group, making it a valuable candidate for various chemical studies.

Key Features:

  • Drug Development: This compound serves as a potential lead in the development of new pharmacological agents, highlighting the significance of structure-activity relationships in medicinal chemistry.
  • Mechanism of Action: Compounds of this type are often explored for their interaction with neurotransmitter systems, which can be essential for treating conditions such as depression and anxiety.
  • Research Applications: Scientists are particularly interested in how such compounds can modulate specific receptors, providing insights into the design of selective ligands.
  • Collaborative Studies: The synthesis and characterization of this compound can foster collaboration across various fields, including organic synthesis, pharmacology, and chemical biology.

As quoted by a prominent chemist, “The path to discovery is paved with unique compounds that unveil the complexity of nature.” This compound exemplifies the intricate balance of chemistry and biology, offering a multitude of avenues for exploration.

With ongoing research, we may uncover even more about its potential therapeutic applications and the ways in which its unique structure can be optimized for better efficacy.

Synonyms
chlorpheniramine
Chlorphenamine
132-22-9
Chlorophenylpyridamine
Teldrin
Chloropheniramine-d4
Clorfeniramina
Clorfenamina
Haynon
Chloropheniramine
Chlor-trimeton
Chlorprophenpyridamine
Allergican
Allergisan
Chloropiril
Histadur
Polaronil
Chlorpheniraminum
Chloroprophenpyridamine
Chlorphenaminum
Phenetron
4-Chloropheniramine
Chlorpheniramine polistirex
Clofeniramina
Chlorphenamin
1-(p-Chlorophenyl)-1-(2-pyridyl)-3-dimethylaminopropane
HSDB 3032
3-(p-Chlorophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine
gamma-(4-Chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine
gamma-(4-Chlorophenyl)-gamma-(2-pyridyl)propyldimethylamine
1-(p-Chlorophenyl)-1-(2-pyridyl)-3-N,N-dimethylpropylamine
3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
3-(4-chlorophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine
Clorfenamina [INN-Spanish]
EINECS 205-054-0
Chlorphenaminum [INN-Latin]
UNII-3U6IO1965U
2-Pyridinepropanamine, gamma-(4-chlorophenyl)-N,N-dimethyl-
Chlo-amine
Chlorphenamine [INN]
CHEBI:52010
3U6IO1965U
CHEMBL505
Chlorphenamine Maleate
Dexchlorpheniramine free base
2-(p-Chloro-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine
Cloropiril
DTXSID0022804
783AHI015X
25523-97-1 (free base)
Chlorphenamine (INN)
3-(4-chlorophenyl)-N,N-dimethyl-3-(2-pyridyl)propan-1-amine
Hayon
Aller-Chlor
TUZISTRA COMPONENET OF CHLORPHENIRAMINE
Clorfenamina (INN-Spanish)
Chlorphenaminum (INN-Latin)
Chloropheniramine maleate
2-[p-chloro-alpha-[2-(dimethylamino)ethyl]benzyl]pyridine
Telachlor
Clorfeniramina [Italian]
(R)-Chloropheniramine
113-92-8
Chlorphenamine [INN:BAN]
PiriIton
Chlor-Pro
[3H]Chlorphenamine
Clofeniramina (TN)
[3H]Chlorpheniramine
chlorpheniaramine maleate
S-(+)-Chlorpheniramine
Prestwick0_000117
Prestwick1_000117
Prestwick2_000117
Prestwick3_000117
NCGC00015227-04
5-HT,N-ACETYL
SCHEMBL4219
Lopac0_000261
Oprea1_779072
BSPBio_000134
CHLORPHENIRAMINE [MI]
DivK1c_000596
SPBio_002073
CHLORPHENIRAMINE [HSDB]
BPBio1_000148
DTXCID402804
GTPL6976
CHLORPHENAMINE [WHO-DD]
CHLORPHENIRAMINE [VANDF]
BDBM35938
KBio1_000596
R06AB04
Chlorpheniramine-d6see c424303
NINDS_000596
HMS2090M21
HMS3428J07
Chlorpheniramine polistirex [USAN]
2-Pyridinepropanamine, .gamma.-(4-chlorophenyl)-N,N-dimethyl-
HBA18809
HY-B0286
BBL012285
STK736174
AKOS001650136
AKOS022060794
CCG-108982
DB01114
SB19135
SDCCGSBI-0050249.P002
IDI1_000596
NCGC00015227-03
NCGC00015227-05
NCGC00015227-06
NCGC00015227-09
NCGC00015227-19
NCGC00162108-01
NCGC00162108-02
DA-62286
CHLORPHENIRAMINE COMPONENT OF TUZISTRA
CS-0009285
NS00010179
C06905
D07398
EN300-708772
G77687
L000003
Q420133
BRD-A04553218-050-03-0
BRD-A04553218-050-08-9
BRD-A04553218-050-16-2
[3-(4-chlorophenyl)-3-(pyridin-2-yl)propyl]dimethylamine
pyridine, 2-[p-chloro-alpha-(2-dimethylaminoethyl)benzyl]-
.gamma.-(4-Chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine
2-(P-CHLORO-.ALPHA.-(2-(DIMETHYLAMINO)ETHYL)BENZYL)PYRIDINE
N-[3-(4-Chlorophenyl)-3-(2-pyridinyl)propyl]-N,N-dimethylamine #
n.-Propanamine, 3-(4-chlorophenyl)-3-(2-pyridyl)-N,N-dimethyl-
2-Pyridinepropanamine, .gamma.-(4-chlorophenyl)-N,N-dimethyl-, (S)-
Pyridine, 2-[p-chloro-.alpha.-[2-(dimethylamino)ethyl]benzyl]-, (S)-(+)-
205-054-0