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PF-04479745

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Identification
Molecular formula
C18H20ClN5
CAS number
956905-27-2
IUPAC name
3-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]-7H-pyrrolo[2,3-b]pyridine
State
State

At room temperature, PF-04479745 is found in a solid state. It is chemically stable and typically stored in airtight containers to prevent exposure to moisture and ambient atmospheric conditions.

Melting point (Celsius)
250.00
Melting point (Kelvin)
523.00
Boiling point (Celsius)
420.00
Boiling point (Kelvin)
693.00
General information
Molecular weight
343.84g/mol
Molar mass
343.8280g/mol
Density
1.2600g/cm3
Appearence

PF-04479745 is typically encountered in a crystalline solid form, with an off-white to light yellow color. Its appearance can vary somewhat depending on the specific conditions of synthesis and any impurities that may be present.

Comment on solubility

Solubility of 3-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]-7H-pyrrolo[2,3-b]pyridine

The solubility of the compound 3-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]-7H-pyrrolo[2,3-b]pyridine (C18H20ClN5) is an important characteristic that influences its potential applications, especially in pharmaceuticals. Understanding its solubility can help predict its behavior in biological systems.

Factors Influencing Solubility

Key factors that impact the solubility of this compound include:

  • Polarity: The presence of polar functional groups can increase solubility in polar solvents, while non-polar characteristics may lead to greater solubility in organic solvents.
  • Hydrogen Bonding: Capable of forming hydrogen bonds may enhance solubility in aqueous solutions.
  • Molecular Size: Larger molecules may present difficulties in dissolving due to steric hindrance.

General Observations

In terms of solubility, the compound can be expected to exhibit:

  • Higher solubility in organic solvents such as ethanol or dimethyl sulfoxide (DMSO).
  • Limited solubility in water, which is common for many compounds that contain aromatic rings.

As highlighted by the general rule of thumb, "like dissolves like," the solubility of this compound can be better understood by considering its chemical structure and composition. Therefore, for practical applications, solubility tests should be conducted to determine its efficacy in various solvents.

Interesting facts

Interesting Facts about 3-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]-7H-pyrrolo[2,3-b]pyridine

This compound is a fascinating example of a complex organic structure that showcases the interplay between pharmacology and chemistry. Often studied for its potential applications in the field of medicinal chemistry, this compound reflects how specific molecular arrangements can influence biological activity. Here are some interesting insights:

  • Pharmacological Potential: The unique structure, which includes a piperazine ring, is known for its pharmacological properties. Compounds with such scaffolds are often investigated for their abilities to interact with neurotransmitter systems in the brain, potentially targeting conditions like anxiety and depression.
  • Chlorine Substitution: The presence of the 4-chlorophenyl group can enhance the biological activity and lipophilicity of the compound. Chlorine atoms are commonly used in drug design to fine-tune the properties of candidate molecules.
  • Novel Ring Structures: The pyrrolo[2,3-b]pyridine core presents an intriguing framework. Such heterocyclic compounds have gained significant attention due to their versatility in synthesizing new drugs, especially in therapeutic areas such as oncology.
  • Synthetic Pathways: The synthesis of this compound may involve intricate multi-step procedures that highlight the creativity and complexity of organic synthesis. Chemists often explore various methodologies to optimize yields and purities when developing such compounds.
  • Structure-Activity Relationship: Understanding how modifications to its structure impact biological activity forms a crucial part of medicinal chemistry research. This compound serves as a crucial scaffold in studies focused on developing new therapeutic agents.

In summary, 3-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]-7H-pyrrolo[2,3-b]pyridine exemplifies how intricate chemical structures can pave the way for innovative drug development. The ongoing research surrounding this compound continues to fuel discussions in the scientific community regarding its potential to influence future treatments.