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Bazedoxifene

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Identification
Molecular formula
C30H34N2O3S
CAS number
198481-32-2
IUPAC name
3-[[4-(2-pyrrolidin-1-ylethoxy)phenyl]methyl]-2-[6-(2-pyrrolidin-1-ylethoxy)-3-pyridyl]benzothiophen-6-ol
State
State

At room temperature, bazedoxifene is typically a solid when in a pure state or as its acetate form used in medications.

Melting point (Celsius)
203.50
Melting point (Kelvin)
476.65
Boiling point (Celsius)
994.30
Boiling point (Kelvin)
1 267.45
General information
Molecular weight
470.68g/mol
Molar mass
470.6140g/mol
Density
2.3835g/cm3
Appearence

Bazedoxifene is a white to off-white powder. It is supplied typically in its acetate salt form for pharmaceutical use.

Comment on solubility

Solubility of 3-[[4-(2-pyrrolidin-1-ylethoxy)phenyl]methyl]-2-[6-(2-pyrrolidin-1-ylethoxy)-3-pyridyl]benzothiophen-6-ol

The solubility profile of the compound 3-[[4-(2-pyrrolidin-1-ylethoxy)phenyl]methyl]-2-[6-(2-pyrrolidin-1-ylethoxy)-3-pyridyl]benzothiophen-6-ol (C30H34N2O3S) is an intriguing aspect due to its complex structure. The solubility can be influenced by several factors:

  • Polarity: The presence of influential functional groups, such as the 2-pyrrolidin-1-ylethoxy substituents, indicates that this compound may exhibit increased solubility in polar solvents.
  • Hydrogen Bonding: The hydroxyl group (-OH) in the benzothiophen-6-ol moiety can facilitate hydrogen bonding with solvents, potentially enhancing solubility.
  • Chain Flexibility: The ethoxy chain may contribute to a favorable solvation by allowing the compound to adapt its conformation in solution.
  • Solvent Interaction: The compatibility with different solvents such as water, methanol, or ethanol should be explored, as it will largely determine the compound's practical applications.

In summary, while predicting the precise solubility of this complex molecular structure without experimental data is challenging, its design suggests a tendency towards higher solubility in polar solvents, making it a compound of interest for various applications.

Interesting facts

Interesting Facts about 3-[[4-(2-pyrrolidin-1-ylethoxy)phenyl]methyl]-2-[6-(2-pyrrolidin-1-ylethoxy)-3-pyridyl]benzothiophen-6-ol

This compound represents a fascinating entry into the world of organic synthesis and medicinal chemistry. Its complex structure, characterized by various functional groups and a unique arrangement of atoms, provides insightful implications for its biological activities.

Key Highlights:

  • Multi-Functional Potential: With its combination of a benzothiophene core and pyrrolidine moieties, this compound may exhibit diverse pharmacological properties, making it a potential candidate for drug development.
  • Structural Diversity: The presence of both aromatic rings and heterocycles in the molecule enhances its ability to interact with biological targets, potentially leading to unique mechanisms of action.
  • Interest in Medicinal Applications: Compounds with similar structures have been explored for their roles in treating conditions such as inflammation, pain, and even neurodegenerative diseases.
  • Research Insights: Studies on similar compounds reveal that functionalizing the benzothiophene or expanding the pyrrolidine substituents can tune their biological activity, suggesting a promising avenue for research.

As a chemist or student in the field, understanding the synthesis and reactivity of such compounds is crucial. The intricate design indicates that tailoring substituents on the core structure can drastically influence the compound's efficacy and selectivity in biological systems.

In sum, this compound not only exemplifies the beauty of organic chemistry but also underscores the potential transformation of synthetic compounds into therapeutic agents. It invites further investigation into its properties and effects, paving the way for innovative breakthroughs in medicine.

Synonyms
3-[4-(2-pyrrolidin-1-yl-ethoxy)-benzyl]-2-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl] -benzo[b]thiophen-6-ol
1d3p
BT3
SCHEMBL8150439
Q27458540
3-(4-(2-(Pyrrolidin-1-yl)ethoxy)benzyl)-2-(6-(2-(pyrrolidin-1-yl)ethoxy)pyridin-3-yl)benzo[b]thiophen-6-ol
3-[4-(2-pyrrolidin-1-ylethoxy)benzyl]-2-[6-(2-pyrrolidin-1-ylethoxy)pyridin-3-yl]-1-benzothiophene-6-ol
828268-55-9