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Methylenedioxymethamphetamine (MDMA)

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Identification
Molecular formula
C12H15NO2
CAS number
42542-10-9
IUPAC name
3-[4-(2-ethoxy-2-phenyl-ethyl)piperazin-1-yl]-2-methyl-1-phenyl-propan-1-one
State
State

At room temperature, MDMA is typically solid in its pure form. The compound is often distributed in crystalline or powdered form and is also pressed into tablets or capsules for recreational use.

Melting point (Celsius)
148.50
Melting point (Kelvin)
421.65
Boiling point (Celsius)
557.30
Boiling point (Kelvin)
830.45
General information
Molecular weight
193.26g/mol
Molar mass
193.2560g/mol
Density
1.2000g/cm3
Appearence

MDMA is commonly found in crystalline powder form. It is often seen in white, off-white, or slightly yellowish colors. When in pill form, it may be colored or stamped with various designs.

Comment on solubility

Solubility of 3-[4-(2-ethoxy-2-phenyl-ethyl)piperazin-1-yl]-2-methyl-1-phenyl-propan-1-one (C12H15NO2)

The solubility of 3-[4-(2-ethoxy-2-phenyl-ethyl)piperazin-1-yl]-2-methyl-1-phenyl-propan-1-one in various solvents can be influenced by its unique structure. Understanding its solubility characteristics is essential for applications in pharmaceutical formulations.

Factors Influencing Solubility

  • Polarity: The introduction of the piperazine and ethoxy group contributes to the overall polarity of the molecule, affecting how it solubilizes in polar vs. non-polar solvents.
  • Hydrogen Bonding: The presence of nitrogen atoms can participate in hydrogen bonding, enhancing solubility in polar solvents like water and alcohols.
  • Molecular Interactions: The phenyl groups may interact favorably with non-polar solvents, suggesting possible solubility in organic solvents like dichloromethane or ethyl acetate.

Potential Solubility Profiles

Based on the structure, one might note:

  • Moderate solubility in water, likely due to hydrogen bonding capabilities.
  • Good solubility in organic solvents like ethanol or acetone owing to its hydrophobic regions.

In conclusion, while specific solubility data is essential for practical applications, the molecular structure suggests a versatility in solubility that can be harnessed effectively in various formulations.

Interesting facts

Interesting Facts about 3-[4-(2-ethoxy-2-phenyl-ethyl)piperazin-1-yl]-2-methyl-1-phenyl-propan-1-one

This compound is an intriguing member of the piperazine family, known for its diverse applications in medicinal chemistry. Here's why it stands out:

  • Pharmacological Potential: The unique structure of this compound allows it to target various biological systems, making it a candidate for developing new therapeutic agents.
  • Piperazine Derivative: The presence of a piperazine ring is significant because it enhances the solubility and bioavailability of drugs, which is crucial in pharmaceutical development.
  • Ether Group Influence: The ethoxy group attached to the phenyl chain plays a critical role in defining the compound's chemical reactivity, which can influence interaction with biological targets.
  • Structural Diversity: The combination of piperazine with a phenyl and an alkyl chain results in a compound that can exhibit varied pharmacokinetic and pharmacodynamic properties, making it a subject of ongoing research.

In addition, scientists appreciate the complexity of its synthesis. The meticulous approach required to construct such a compound not only enhances its uniqueness but also provides valuable insights into synthetic methods used in organic chemistry. Furthermore, understanding the interactions of this compound with various receptors can pave the way for innovative therapeutic strategies that enhance patient care and treatment outcomes.

As a chemistry student, exploring compounds like this can stimulate a deeper understanding of structure-activity relationships, expanding your insight into how slight modifications can yield significant changes in biologically active compounds.

Synonyms
Eprazinone
10402-90-1
3-(4-(2-Ethoxy-2-phenylethyl)piperazin-1-yl)-2-methyl-1-phenylpropan-1-one
Eprazinona
Eprazinonum
3-[4-(2-ethoxy-2-phenylethyl)piperazin-1-yl]-2-methyl-1-phenylpropan-1-one
Eprazinone [INN:DCF]
Eprazinonum [INN-Latin]
Eprazinona [INN-Spanish]
1-(2-Phenyl-2-ethoxyethyl)-4-(2-benzyloxypropyl)piperazine
EINECS 233-873-3
UNII-883YNL63WU
Eprazinone (INN)
BRN 0844684
883YNL63WU
3-(4-(beta-Ethoxyphenethyl)-1-piperazinyl)-2-methylpropiophenone
CHEBI:82716
EPRAZINONE [MI]
EPRAZINONE [INN]
EPRAZINONE [WHO-DD]
3-(4-(2-Ethoxy-2-phenylethyl)-1-piperazinyl)-2-methyl-1-phenyl-1-propanone
DTXSID1048336
5-23-02-00216 (Beilstein Handbook Reference)
1-Propanone, 3-(4-(2-ethoxy-2-phenylethyl)-1-piperazinyl)-2-methyl-1-phenyl-
1-Propanone, 3-[4-(2-ethoxy-2-phenylethyl)-1-piperazinyl]-2-methyl-1-phenyl-
3-(4-(.beta.-Ethoxyphenethyl)-1-piperazinyl)-2-methylpropiophenone
Propiophenone, 2-(4-(beta-ethoxyphenethyl)-1-piperazinyl)methyl-
Eprazinonum (INN-Latin)
Eprazinona (INN-Spanish)
3-[4-(.beta.-Ethoxyphenylethyl)-1-piperazinyl]-2-methylpropiophenone
Propiophenone, 2-(4-(.beta.-ethoxyphenethyl)-1-piperazinyl)methyl-
3-[4-(2-ethoxy-2-phenyl-ethyl)piperazin-1-yl]-2-methyl-1-phenyl-propan-1-one;3-[4-(2-ethoxy-2-phenyl-ethyl)piperazin-1-yl]-2-methyl-1-phenyl-propan-1-one
NCGC00167445-01
Eprazinon
MFCD00866843
SCHEMBL20156
CHEMBL1885437
DTXCID6028311
R05CB04
HY-B2078
AKOS005066066
DB08990
NCGC00167445-03
AS-73208
DB-040504
CS-0017484
NS00010370
D07902
F15043
SBI-0654070.0001
AB01565801_02
Q389207
SR-01000945262
SR-01000945262-1
BRD-A72212290-300-01-4
BRD-A72212290-300-02-2
1-(2-phenyl-2-ethoxy)ethyl-4-(2-benzyloxy)propylpiperazine
3-(4-(beta-Ethoxyphenylethyl)-1-piperazinyl)-2-methylpropiophenone
1-(2-phenyl-2-ethoxy)ethyl-4-(3-phenyl-2-methyl-3-propanone)piperazine
3-[4-(2-ethoxy-2-phenyl-ethyl)piperazin-1-yl]-2-methyl-1-phenyl-propan-1-one
233-873-3
3-[4-(2-Ethoxy-2-phenylethyl)-1-piperazinyl]-2-methyl-1-phenyl-1-propanone, dihydrochloride