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Uridine 5'-monophosphate

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Identification
Molecular formula
C9H13N2O9P
CAS number
58-97-9
IUPAC name
3-[3,4-dihydroxy-5-(phosphonooxymethyl)tetrahydrofuran-2-yl]-2,6-dioxo-pyrimidine-4-carboxylic acid
State
State

At room temperature, Uridine 5'-monophosphate is typically in a solid state. It is often encountered as a powder in laboratory settings, which can be easily dissolved in water to be utilized in aqueous solutions for various biochemical applications.

Melting point (Celsius)
205.00
Melting point (Kelvin)
478.15
Boiling point (Celsius)
300.00
Boiling point (Kelvin)
573.15
General information
Molecular weight
324.18g/mol
Molar mass
324.1820g/mol
Density
2.2300g/cm3
Appearence

Uridine 5'-monophosphate (UMP) typically appears as a white crystalline powder. It is soluble in water and commonly used in biological and chemical research as a nucleotide for synthesizing RNA. Its crystalline nature can be observed under a microscope, characterized by a uniform and well-defined crystal structure. UMP does not have any significant odor.

Comment on solubility

Solubility of 3-[3,4-dihydroxy-5-(phosphonooxymethyl)tetrahydrofuran-2-yl]-2,6-dioxo-pyrimidine-4-carboxylic acid

The compound with the formula C9H13N2O9P shows distinct solubility characteristics due to its complex structural features. This compound is expected to exhibit high solubility in polar solvents, particularly in:

  • Water: Given its numerous hydroxyl (–OH) and phosphono (–PO3H2) functional groups, the molecule can form hydrogen bonds with water molecules, enhancing its solubility.
  • Alcohols: Similar to water, alcohols can solvate the compound effectively due to their polar nature.

In contrast, its solubility in non-polar solvents such as hexane or toluene is expected to be extremely low. This is primarily due to the compound's:

  • Hydrophilic groups: The presence of multiple polar functional groups makes it unfavorable for the compound to interact with non-polar environments.
  • Overall molecular structure: The significant number of functional groups contributes to a strong interaction with polar solvents, further reducing solubility in non-polar solvents.

In conclusion, the solubility profile of this compound illustrates the essential principles of solubility, where like dissolves like: polar solvents enhance solubility, whereas non-polar solvents significantly impede it. Understanding these solubility characteristics is crucial for practical applications, including formulation and chemical interactions.

Interesting facts

Interesting Facts about 3-[3,4-Dihydroxy-5-(phosphonooxymethyl)tetrahydrofuran-2-yl]-2,6-dioxo-pyrimidine-4-carboxylic Acid

This intriguing compound, characterized by its complex structure, combines elements of both sugar and nucleobase chemistry, making it a fascinating subject for study in the field of biochemistry. Here are some noteworthy points about this compound:

  • Enzymatic Role: It is known to act as an intermediate in various biochemical pathways, particularly those involved in nucleotide metabolism.
  • Phosphorylation: The presence of phosphonooxymethyl groups enhances its biological activity, potentially influencing intracellular signaling mechanisms.
  • Hydroxyl Groups: The dihydroxy groups contribute to its solubility and reactivity, playing critical roles in its interaction with other biomolecules.
  • Structural Diversity: The hybrid nature of the molecule, featuring both pyrimidine and sugar moieties, invites comparisons with nucleosides and other related compounds, emphasizing the diversity of chemical structures found in nature.

Moreover, this compound underscores the importance of structure-function relationships in biochemistry. As noted by scientists, "Understanding the intricacies of molecular interactions can reveal insights into biological systems and metabolic pathways." The study of such compounds can lead to valuable applications in drug design and biotechnology, as they pave the way for the development of new therapeutic agents.

Overall, the bioactive nature and structural complexity of this compound make it a compelling topic of discussion for students and researchers alike, bridging concepts in organic chemistry, molecular biology, and pharmacology.

Synonyms
SCHEMBL12727823
DTXSID60862848
Q3138530
2,6-Dioxo-3-(5-O-phosphonopentofuranosyl)-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid