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Guanosine

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Identification
Molecular formula
C10H13N5O5
CAS number
118-00-3
IUPAC name
3-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-2,4-dihydropyrazolo[4,3-d]pyrimidin-7-one
State
State

At room temperature, guanosine is a solid.

Melting point (Celsius)
256.00
Melting point (Kelvin)
529.15
Boiling point (Celsius)
512.10
Boiling point (Kelvin)
785.25
General information
Molecular weight
283.24g/mol
Molar mass
283.2410g/mol
Density
1.9800g/cm3
Appearence

Guanosine is a white to off-white crystalline powder. It is odorless and is often found in its hydrated form.

Comment on solubility

Solubility of 3-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-2,4-dihydropyrazolo[4,3-d]pyrimidin-7-one

The solubility of the compound 3-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-2,4-dihydropyrazolo[4,3-d]pyrimidin-7-one (C10H13N5O5) is influenced by several factors due to its complex structure. Understanding its solubility profile can provide insight into its potential applications and formulations.

Factors Affecting Solubility

  • Polarity: The presence of multiple hydroxyl groups significantly increases the polarity of the molecule, enhancing its solubility in polar solvents like water.
  • Hydrogen Bonding: The ability to form hydrogen bonds with solvents further contributes to solubility. This compound's functional groups can engage in hydrogen bonding, which is critical for dissolution.
  • Molecular Size: The relatively small molecular size allows for better solvation in solutions, although sterics can play a role in limiting interaction in some cases.
  • pH Sensitivity: Changes in pH may impact ionization states, which can either increase or decrease solubility in aqueous solutions.

It is often said that “like dissolves like,” and in this case, the structure's hydroxyl functionalities make it particularly soluble in aqueous environments. However, specific quantitative solubility data can vary based on temperature and the presence of other solutes. Overall, understanding the solubility characteristics is essential for both practical applications and theoretical studies regarding the behavior of this compound in different environments.

Interesting facts

Interesting Facts about 3-[3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-2,4-dihydropyrazolo[4,3-d]pyrimidin-7-one

This intriguing compound, often referred to in the realm of medicinal chemistry, belongs to a class of molecules known for their potential biological activities. Here are some interesting facets to consider:

  • Diverse Applications: This compound is structurally unique, making it a candidate for research in various therapeutic areas, particularly in cancer research and pharmacology. Its pyrazolo[4,3-d]pyrimidine scaffold is notable for its potential in developing anti-inflammatory and anti-cancer agents.
  • Natural Product Inspiration: The inclusion of the tetrahydrofuran ring structure, derived from natural sources, highlights the importance of natural products in drug discovery. The presence of hydroxymethyl groups suggests enhanced biological activity due to increased solubility and potential interactions with biological targets.
  • Structure-Activity Relationship (SAR): Scientists are continuously investigating the structure-activity relationships of this compound. Modifications to the hydroxyl and amino groups can lead to varied biological responses, making it a fascinating subject for synthetic chemists.
  • Future Prospects: Ongoing studies may reveal more about the compound's mechanism of action. With the rise of personalized medicine, compounds like this one may contribute to more targeted therapeutic strategies.
  • Collaborative Research: Research on this compound may often involve interdisciplinary approaches, bridging the gaps between organic chemistry, medicinal chemistry, and pharmacology, highlighting the collaborative nature of modern scientific inquiry.
  • Quote: As the renowned chemist Linus Pauling once stated, "The best way to have a good idea is to have a lot of ideas." This compound exemplifies the creativity and innovation in the field of compound exploration.

In summary, the structural complexity and potential applications of 3-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-2,4-dihydropyrazolo[4,3-d]pyrimidin-7-one emphasize the significance of this compound in ongoing scientific research.