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Sertraline

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Identification
Molecular formula
C17H17Cl2N
CAS number
79617-96-2
IUPAC name
3-(3,4-dichlorophenyl)-N-methyl-indan-1-amine
State
State

At room temperature, sertraline is a solid.

Melting point (Celsius)
246.00
Melting point (Kelvin)
519.15
Boiling point (Celsius)
334.00
Boiling point (Kelvin)
607.15
General information
Molecular weight
306.23g/mol
Molar mass
306.2340g/mol
Density
1.2747g/cm3
Appearence

Sertraline appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of 3-(3,4-dichlorophenyl)-N-methyl-indan-1-amine (C17H17Cl2N)

The solubility of 3-(3,4-dichlorophenyl)-N-methyl-indan-1-amine in various solvents can be influenced by its unique chemical structure and the presence of chlorine atoms. Here are some key points regarding its solubility:

  • Polar Solvents: This compound is likely to show less solubility in polar solvents due to its hydrophobic indan moiety and chlorinated phenyl ring.
  • Non-Polar Solvents: It is expected to have higher solubility in non-polar organic solvents such as aromatic hydrocarbons or aliphatic hydrocarbons.
  • Factors Influencing Solubility:
    • Presence of Cl atoms may enhance solubility in certain medium due to dipole interactions.
    • Overall molecular size and structure can hinder solubility in aqueous phases.
  • Practical Implications: Its solubility profile is essential for applications in pharmaceuticals and material science, guiding formulation strategies.

In conclusion, while predicting the solubility of 3-(3,4-dichlorophenyl)-N-methyl-indan-1-amine can be complex, understanding its molecular characteristics allows for educated estimations of its behavior in various solvents.

Interesting facts

Interesting Facts about 3-(3,4-Dichlorophenyl)-N-methyl-indan-1-amine

3-(3,4-Dichlorophenyl)-N-methyl-indan-1-amine, a unique organic compound, has garnered attention in the realm of medicinal chemistry due to its structural characteristics and potential applications. Here are some intriguing aspects worth noting:

  • Molecular Structure: The compound features a complex indan amine structure, which contributes to its biological activity. The indane ring system fused with an amine group provides a scaffold that can mimic neurotransmitters.
  • Pharmacological Potential: Due to the presence of the dichlorophenyl group, this compound may exhibit affinity for certain receptors in the central nervous system. These interactions could make it a candidate for studies related to mood disorders or neurodegenerative diseases.
  • Synthesis Challenges: The synthesis of such a compound typically involves multi-step organic reactions, which could include halogenation, amination, and ring closures. Each step requires careful control of reaction conditions to yield the desired product effectively.
  • Environmental Considerations: Compounds with halogen substituents, like chlorine, often raise environmental concerns due to their persistence and potential toxicity. Researchers are increasingly focusing on the ecological impact of such compounds through environmental chemistry.

As a scientist or chemistry student delving into compounds like 3-(3,4-dichlorophenyl)-N-methyl-indan-1-amine, it’s fascinating to explore how modifications in molecular structure can lead to different biological activities, and how understanding these elements can contribute to advancements in medicinal therapy.

Synonyms
CHEMBL296602
indatralina
[3-(3,4-Dichloro-phenyl)-indan-1-yl]-methyl-amine
SCHEMBL11128740
DTXSID00861092
3-(3,4-dichlorophenyl)-N-methyl-2,3-dihydro-1H-inden-1-amine
BDBM50021226
[3-(3,4-Dichloro-phenyl)-indan-1-yl]-methyl-amine; hydrochloride
(1rs,3sr)-3-(3,4-dichlorophenyl)-1-methylamino-2,3-dihydro-1h-indene