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Mitoxantrone

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Identification
Molecular formula
C22H28N4O6
CAS number
65271-80-9
IUPAC name
3-[3-(dimethylamino)-2-hydroxy-propyl]-7-methoxy-23-methyl-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17,19,21-nonaene-12,14-dione
State
State

At room temperature, Mitoxantrone is in a crystalline solid state. It is typically handled in solution form during medical applications.

Melting point (Celsius)
215.00
Melting point (Kelvin)
488.15
Boiling point (Celsius)
315.00
Boiling point (Kelvin)
588.15
General information
Molecular weight
444.49g/mol
Molar mass
444.5000g/mol
Density
1.3400g/cm3
Appearence

Mitoxantrone is a blue-black crystalline powder that typically appears in a solid form. It is water-soluble and is usually encountered as a hydrochloride salt with a characteristic dark appearance.

Comment on solubility

Solubility of 3-[3-(dimethylamino)-2-hydroxy-propyl]-7-methoxy-23-methyl-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17,19,21-nonaene-12,14-dione

The solubility of the compound with the chemical formula C22H28N4O6 is a key parameter that can influence its bioavailability and effectiveness in various applications. Here are some crucial points regarding its solubility:

  • Water Solubility: Typically, complex organic compounds such as this one exhibit poor solubility in water due to their large and intricate structures.
  • Solvent Compatibility: The solubility may vary significantly in different organic solvents. Solvents like ethanol or methanol could show better solubility.
  • Polarity Effects: The presence of functional groups, such as dimethylamino and hydroxy, often enhances solubility, yet the overall hydrophobic nature can hinder it.
  • Temperature Influence: Solubility can increase with temperature, suggesting that heated solvents may provide better dissolution outcomes.
  • pH Considerations: The solubility might also be affected by the pH of the solution, particularly because the compound contains basic amine groups.

In conclusion, while specific solubility data may not be readily available, understanding the underlying factors that affect solubility can assist researchers in developing effective dissolution strategies for this compound. To quote, "solubility is not merely a property; it is a mixture of chemical composition and environmental interactions."

Interesting facts

Interesting Facts about 3-[3-(dimethylamino)-2-hydroxy-propyl]-7-methoxy-23-methyl-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17,19,21-nonaene-12,14-dione

This compound, with its intricate structure and diverse functional groups, presents numerous fascinating aspects for both chemists and those interested in the field of organic synthesis. It belongs to the class of tricyclic compounds, featuring a complex arrangement of rings, which can lead to interesting properties and potential applications.

Key Highlights:

  • Structural Complexity: The unique trifunctional and multi-cyclic arrangement enables varied reactivity and interaction with biological systems, making it a subject of interest in medicinal chemistry.
  • Dimethylamino Group: This part of the molecule can enhance the compound's lipophilicity and influence its pharmacological properties, promoting permeability across biological membranes.
  • Potential Applications: Compounds of this type may serve as starting materials for drug synthesis, especially in the development of pharmaceuticals targeting neurological conditions.
  • Hydroxy and Methoxy Functional Groups: These groups can participate in hydrogen bonding, influencing the solubility and reactivity of the compound.

As stated by several chemists in the field, "Understanding the nuances of complex compounds broadens our horizons in drug discovery." This specific compound serves as a reminder of the amazing potential found in organic chemistry and highlights the importance of investigating multifaceted molecular architectures. With ongoing studies, the full extent of its properties and applications may soon be unraveled.


Overall, this fascinating compound provides a rich ground for further exploration and exemplifies the depth of creativity found in chemical synthesis and research.

Synonyms
go 7874
Go7874
153207-86-4
CHEMBL157822
3-[3-(dimethylamino)-2-hydroxypropyl]-7-methoxy-23-methyl-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17,19,21-nonaene-12,14-dione
Go-7874
Gouml 7874
GTPL335
SCHEMBL4882087
BDBM50284318
AKOS040748440
HY-117786
G? 7874
Q27077834
[3-(dimethylamino)-2-hydroxy-propyl]-methoxy-methyl-[?]dione
13-(3-(dimethylamino)-2-hydroxypropyl)-3-methoxy-12-methyl-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
13-(3-dimethylamino-2-hydroxypropyl)-3-methoxy-12-methyl-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione
8-[3-(Dimethylamino)-2-hydroxypropyl]-5-methoxy-9-methyl-2H-azolidino[3,4-c]indolo[2,3-a]carbazole-1,3-dione