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Puromycin

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Identification
Molecular formula
C22H29N7O5
CAS number
58-58-2
IUPAC name
3-[[3-amino-5-[carbamimidoyl(methyl)amino]pentanoyl]amino]-6-(4-amino-2-oxo-pyrimidin-1-yl)-3,6-dihydro-2H-pyran-2-carboxylic acid
State
State

Under standard conditions, Puromycin is a solid compound.

Melting point (Celsius)
175.00
Melting point (Kelvin)
448.15
Boiling point (Celsius)
511.50
Boiling point (Kelvin)
784.65
General information
Molecular weight
471.53g/mol
Molar mass
471.5250g/mol
Density
1.3000g/cm3
Appearence

Puromycin appears as a white to off-white crystalline powder. It is a solid at room temperature and is often provided as a hydrochloride salt in lab settings.

Comment on solubility

Solubility of 3-[[3-amino-5-[carbamimidoyl(methyl)amino]pentanoyl]amino]-6-(4-amino-2-oxo-pyrimidin-1-yl)-3,6-dihydro-2H-pyran-2-carboxylic acid

The solubility of the compound C22H29N7O5 can be quite intriguing due to its complex structure and multiple functional groups. This compound appears to fall into the category of polar molecules due to the presence of amine (–NH2), carboxylic acid (–COOH), and possibly other heteroatoms in its framework.

Factors Influencing Solubility

Several factors can significantly affect the solubility of this compound:

  • Polarity: The multiple polar groups can lead to high solubility in polar solvents such as water.
  • Hydrogen Bonding: The ability to form hydrogen bonds with water molecules generally enhances solubility. Compounds with multiple –NH2 and –COOH groups tend to solvate well.
  • pH of the Solvent: The carboxylic acid group can ionize at certain pH levels, which can increase solubility in aqueous solutions.
  • Solvent-Solute Interactions: Similarity in the polarity and functional groups between the solute and solvent can lead to favorable interactions.

Expected Solubility Behavior

Given these considerations, one might expect:

  • The compound is likely to be soluble in water, particularly at physiological pH levels.
  • Limited solubility in non-polar solvents due to the presence of polar functionalities.
  • The possibility of reactivity with other compounds in solution can also affect its solubility characteristics.

In conclusion, while predicting the precise solubility requires empirical data, the structural attributes suggest a predominantly polar nature, likely leading to increased solubility in aqueous environments.

Interesting facts

3-[[3-amino-5-[carbamimidoyl(methyl)amino]pentanoyl]amino]-6-(4-amino-2-oxo-pyrimidin-1-yl)-3,6-dihydro-2H-pyran-2-carboxylic acid

This compound is a fascinating example of a complex organic molecule that blends amino acids, pyrimidine derivatives, and functional groups, showcasing the intricate connections within biochemical pathways. Its structure indicates a significant role in potential biological activities, making it of great interest in pharmaceutical and medicinal chemistry.

Key Features:

  • Multifunctionality: The compound integrates multiple functional groups, which may interact with specific biological targets, making it a candidate for drug development.
  • Protein Interactions: The incorporation of amino acids hints at potential interactions with proteins, possibly impacting enzymatic activities or receptor binding—which are vital in therapeutic contexts.
  • Pyrimidine Structure: The presence of the pyrimidine ring could enhance the compound's ability to interfere with nucleic acid synthesis or modulate related cellular processes, providing routes for research in genetic medicine.

Interestingly, the compound's intricate design may lead to challenges in synthesis and characterization; however, such complexity often correlates with unique biological efficacy. As scientists continue to explore similar molecules, this compound can serve as a template for creating new therapeutics that target specific diseases. Its potential also extends to understanding metabolic pathways, as it may mimic or inhibit substrates within biological systems.

In summary, 3-[[3-amino-5-[carbamimidoyl(methyl)amino]pentanoyl]amino]-6-(4-amino-2-oxo-pyrimidin-1-yl)-3,6-dihydro-2H-pyran-2-carboxylic acid not only exemplifies the beauty of molecular architecture but also represents the frontier of modern medicinal chemistry, where intricate structures pave the way for groundbreaking discoveries.

Synonyms
Blasticidin S
NSC613045
2079-00-7
Blasticidin S, Hydrochloride
SCHEMBL21704
CHEMBL1622944
DTXSID80862825
CAA07900
NSC-613045
DB-045371
1-(4-{(Z)-[3-Amino-1-hydroxy-5-(N-methylcarbamimidamido)pentylidene]amino}-2,3,4-trideoxyhex-2-enopyranuronosyl)-4-imino-1,4-dihydropyrimidin-2-ol
2(1H)-Pyrimidinone, 1-[4-[[3-amino-5-[(aminoiminomethyl)methylamino]-1-oxopentyl]amino]-2,3,4-trideoxyhex-2-enopyranuronosyl]-3,4-dihydro-4-imino-
3-[[3-amino-5-[carbamimidoyl(methyl)amino]pentanoyl]amino]-6-(4-imino-2-oxo-pyrimidin-1-yl)-3,6-dihydro-2H-pyran-2-carboxylic acid