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Clomipramine

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Identification
Molecular formula
C19H23Cl2NO
CAS number
303-49-1
IUPAC name
3-(2,4-dichlorophenoxy)-N-methyl-N-prop-2-ynyl-propan-1-amine
State
State

At room temperature, clomipramine is a solid compound.

Melting point (Celsius)
188.50
Melting point (Kelvin)
461.70
Boiling point (Celsius)
369.40
Boiling point (Kelvin)
642.50
General information
Molecular weight
314.18g/mol
Molar mass
314.1830g/mol
Density
1.1370g/cm3
Appearence

Clomipramine typically appears as a pale yellow to beige powder. It may also be available in the form of capsules for pharmaceutical use. It is hygroscopic and should be stored in a tightly sealed container to protect it from moisture.

Comment on solubility

Solubility of 3-(2,4-dichlorophenoxy)-N-methyl-N-prop-2-ynyl-propan-1-amine

The compound 3-(2,4-dichlorophenoxy)-N-methyl-N-prop-2-ynyl-propan-1-amine (C19H23Cl2NO) exhibits notable solubility characteristics. Understanding the solubility of this compound is essential for its applications in various fields.

Factors Influencing Solubility

  • Presence of Chlorine Atoms: The two chlorine atoms can impact solubility due to their electronegativity, which can create polar characteristics in the molecule.
  • Phenoxy Group: The phenoxy group contributes to the overall hydrophobic nature, possibly reducing solubility in water.
  • Amine Group: The presence of the amine functional group could enhance solubility in polar solvents, influencing its interaction with water and organic solvents.

Expected Solubility

Given the structural features of this compound, one might expect:

  • Moderate solubility in organic solvents such as ethanol and acetone.
  • Limited solubility in water due to the hydrophobic interactions from the phenyl and chlorinated groups.

Overall, while solubility can vary depending on the solvent system, the combination of hydrophobic and hydrophilic interactions complicates predictions. As always, empirical testing is advisable to determine the precise solubility in different environments.

Interesting facts

Interesting Facts about 3-(2,4-dichlorophenoxy)-N-methyl-N-prop-2-ynyl-propan-1-amine

This compound, known for its intriguing structure and properties, belongs to a class of chemicals often studied in medicinal chemistry and agriculture. Here are some noteworthy aspects:

  • Origin: The compound's structure features a dichlorophenoxy group, which is often found in herbicides and can impact plant growth and development.
  • Biological Activity: Research indicates that compounds similar to this one may exhibit a range of biological activities, making them of interest in pharmacological studies.
  • Symmetry and Functionality: The presence of both chlorinated aromatic rings and an amine group in its structure exhibits unique symmetry and gives it diverse functional properties.
  • Synthetic Pathways: Understanding the synthesis of this compound can provide insights into functionalization techniques used in organic chemistry, particularly with ynyl and amine groups.

As a student, you might find it fascinating that compounds like this one can serve as a bridge between herbicide design and therapeutic agents. They showcase the principles of structure-activity relationships (SAR) in drug development, where even minute changes in structure can lead to vastly different biological outcomes. Always remember the words of renowned chemist Linus Pauling: "The best way to have a good idea is to have lots of ideas."

In your future chemistries, whether they relate to agriculture or pharmaceuticals, consider how the intricate design of a compound can lead to innovative solutions and breakthroughs!

Synonyms
Clorgiline
CLORGYLINE
17780-72-2
Chlorgyline
Clorgilina
Clorgilinum
Clorgiline [INN]
M and B 9302
Clorgilinum [INN-Latin]
Clorgilina [INN-Spanish]
n-methyl-n-propargyl-3-(2,4-dichlorophenoxy)propylamine
M & B 9302
Clorgiline (INN)
M&B 9302
N-(3-(2,4-Dichlorophenoxy)propyl)-N-methyl-2-propynylamine
UNII-LYJ16FZU9Q
BRN 1976758
CHEBI:3763
Clorgiline [INN:BAN]
LYJ16FZU9Q
N-(3-(2,4-dichlorophenoxy)propyl)-N-methylprop-2-yn-1-amine
CHEMBL8706
Clorgilin
DTXSID3048445
N-[3-(2,4-dichlorophenoxy)propyl]-N-methylprop-2-yn-1-amine
2-Propyn-1-amine, N-(3-(2,4-dichlorophenoxy)propyl)-N-methyl-
M&B-9302
2-Propynylamine, N-(3-(2,4-dichlorophenoxy)propyl)-N-methyl-
Clorgilinum (INN-Latin)
Clorgilina (INN-Spanish)
2-Propyn-1-amine, N-(3-(2,4-dichlorophenoxy)propyl)-N-methyl- (9CI)
CAS-17780-75-5
3-(2,4-dichlorophenoxy)-N-methyl-N-prop-2-ynylpropan-1-amine
Prestwick0_000344
Prestwick1_000344
Prestwick2_000344
Prestwick3_000344
Lopac-M-3778
Lopac0_000746
SCHEMBL61914
BSPBio_000407
US8633208, Clorgyline
SPBio_002328
BPBio1_000449
GTPL6636
DTXCID9028419
BDBM15581
EX-A10906
CCG-204831
DB04017
SDCCGSBI-0050724.P003
NCGC00015669-01
NCGC00015669-02
NCGC00015669-03
NCGC00015669-04
NCGC00015669-11
NCGC00162235-01
AS-85980
HY-14197
SBI-0050724.P002
DB-266520
CS-0002917
NS00071662
D03248
L001342
Q2889652
BRD-K73251053-003-03-2
BRD-K73251053-003-13-1
BRD-K73251053-003-21-4
BRD-K73251053-003-22-2
[3-(2,4-Dichloro-phenoxy)-propyl]-methyl-prop-2-ynyl-amine
[3-(2,4-dichlorophenoxy)propyl](methyl)prop-2-yn-1-ylamine
N-[3-(2,4-dichlorophenoxy)propyl]-N-methyl-2-propyn-1-amine
N-[3-(2,4-dichlorophenoxy)propyl]-N-methyl-prop-2-yn-1-amine
3-(2,4-dichlorophenoxy)-N-methyl-N-prop-2-ynyl-propan-1-amine
CLG