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Anabasine

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Identification
Molecular formula
C10H14N2
CAS number
494-52-0
IUPAC name
3-(2-piperidyl)pyridine
State
State

At room temperature, anabasine is generally in a liquid state. As an oily substance, it can solidify into a crystalline form at lower temperatures.

Melting point (Celsius)
-16.50
Melting point (Kelvin)
256.65
Boiling point (Celsius)
262.50
Boiling point (Kelvin)
535.65
General information
Molecular weight
162.24g/mol
Molar mass
162.2480g/mol
Density
1.0966g/cm3
Appearence

Anabasine appears as a colorless to pale yellow, oily liquid. It is known to have a characteristic pungent odor, often described as similar to nicotine.

Comment on solubility

Solubility of 3-(2-piperidyl)pyridine (C10H14N2)

The solubility of 3-(2-piperidyl)pyridine, a compound featuring both a pyridine and a piperidine moiety, exhibits unique characteristics due to its chemical structure. Generally, the solubility of such nitrogen-containing heterocycles can be influenced by several factors:

  • Polarity: The presence of nitrogen atoms increases the polarity of the molecule, which may enhance its solubility in polar solvents.
  • Hydrogen Bonding: The ability of the compound to form hydrogen bonds can also play a significant role. This can facilitate interactions with solvents like water.
  • Alkyl Groups: The alkyl groups present may impart some hydrophobic character, potentially affecting its overall solubility profile.

In practice, 3-(2-piperidyl)pyridine is likely to be soluble in:

  • Polar organic solvents such as ethanol and methanol
  • Aqueous solutions at varying pH levels due to its basic nature

However, it may show limited solubility in less polar solvents like hydrocarbons. Understanding these solubility characteristics is crucial for applications in pharmaceuticals and chemical synthesis.

Interesting facts

Interesting Facts about 3-(2-piperidyl)pyridine

3-(2-piperidyl)pyridine is a fascinating compound that forms a bridge between the realms of organic chemistry and pharmacology. This compound is particularly notable for its structural complexity and the presence of both heterocyclic and aliphatic components, which leads to various interesting properties and applications.

Key Features:

  • Structure: This compound includes a pyridine ring, which is a common feature in many biologically active molecules, enhancing its potential for interactions with biological targets.
  • Biological Activity: Compounds containing piperidine moieties, like 3-(2-piperidyl)pyridine, are often explored for their roles in medicinal chemistry and their ability to act as pharmacophores.
  • Applications: Due to its structural features, it may be investigated for use in developing drugs targeting neurological conditions or for anti-inflammatory purposes.
  • Research Interest: Its potential as a ligand in coordination chemistry and its utility in forming various derivatives make it a topic of ongoing research in both organic synthesis and medicinal chemistry.

Because of its duality in structure, 3-(2-piperidyl)pyridine can participate in various chemical reactions such as electrophilic substitution, making it versatile for synthetic chemistry. Researchers are intrigued by the compound's capability to form strong hydrogen bonds, which may influence its reactivity and interactions in biological systems.

As emphasized by many in the field, understanding compounds like 3-(2-piperidyl)pyridine can lead to the development of *innovative therapies* that tackle a range of diseases, showcasing the vital links between chemistry and medicine. The exploration of this compound highlights the importance of structural chemistry in drug design and the development of new materials.

Synonyms
3-(piperidin-2-yl)pyridine
13078-04-1
Anabasine
(+/-)-Anabasine
3-piperidin-2-ylpyridine
(+-)-Anabasine
DL-Anabasine
(R,S)-ANABASINE
2-Pyridin-3-ylpiperidine
Pyridine, 3-(2-piperidinyl)-
(+/-)Anabasine
40774-73-0
(+/-) Anabasine
MFCD00006370
2-(3-Pyridyl)piperidine
2-(3-Pyridinyl)piperidine
CHEMBL280963
CHEBI:28986
( inverted exclamation markA) Anabasine
1,2,3,4,5,6-Hexahydro-[2,3']Bipyridinyl
3-[(2RS)-Piperidin-2-yl]pyridine ((RS)-Anabasine)
3-(2-piperidyl)pyridine
MLS000737148
2-(3-Pyridinyl)piperidine #
SR-01000765740
() Anabasine
Spectrum_000023
Anabasine, (+/-)
Anabasine, >=97%
SpecPlus_000616
(.+/-.)-Anabasine
Prestwick0_000669
Prestwick1_000669
Prestwick2_000669
Spectrum2_001792
Spectrum3_001356
Spectrum4_000071
Spectrum4_001899
Spectrum5_000558
2-(3-PYRIDYL)PIPERIDINE/(-)-ANABASINE
BSPBio_003171
KBioGR_000621
KBioGR_002463
KBioSS_000383
DivK1c_006712
SCHEMBL117530
2-(pyridin-3-yl)-piperidine
SPBio_001743
SPBio_002658
KBio1_001656
KBio2_000383
KBio2_002951
KBio2_005519
KBio3_002391
DTXSID50859409
HMS1570E19
HMS2269F13
rac.-2-(pyridin-3-yl)piperidine
ALBB-006068
BDBM50026461
PDSP1_000171
PDSP2_000170
STK028316
AKOS000276953
AKOS016050677
PYRIDINE,3-(2-PIPERIDINYL)-
AB00736
AB07621
AB49757
CCG-208545
FA17897
HY-W052144
PS-4547
SDCCGMLS-0066614.P001
SMP2_000070
NCGC00017173-02
NCGC00163365-01
AC-10023
SMR000528391
SY062144
DB-008085
DB-015784
CS-0044923
NS00010643
(+/-)-Anabasine, >=90% (TLC), liquid
EN300-95113
C06180
N10845
Q419308
SR-01000765740-4
BRD-A24284985-001-09-9
BRD-A24284985-003-03-8
E48D8A38-D352-4AA3-BCCF-B14E46A0556C
F2158-0913
(R,S)-3-(2-Piperidinyl)pyridine;(+/-)-Anabasine;1,2,3,4,5,6-Hexahydro-[2,3']bipyridinyl;Neonicotine