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Guaiacol glycerol ether

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Identification
Molecular formula
C10H14O4
CAS number
93-14-1
IUPAC name
3-(2-methoxyphenoxy)propane-1,2-diol
State
State

Guaiacol glycerol ether is typically a solid at room temperature under standard conditions. It is known to be quite stable and is frequently used in both academic research and practical applications involving its expectorant qualities.

Melting point (Celsius)
76.00
Melting point (Kelvin)
349.15
Boiling point (Celsius)
310.80
Boiling point (Kelvin)
583.95
General information
Molecular weight
198.22g/mol
Molar mass
198.2150g/mol
Density
1.1227g/cm3
Appearence

Guaiacol glycerol ether appears as a white crystalline solid or powder. It is often used in formulations for its mild expectorant properties and has a faint pleasant odor reminiscent of vanilla or liqourice, depending on purity and storage conditions.

Comment on solubility

Solubility of 3-(2-methoxyphenoxy)propane-1,2-diol (C10H14O4)

The solubility of 3-(2-methoxyphenoxy)propane-1,2-diol in various solvents is influenced by its molecular structure and functional groups. Here are some key points to consider:

  • Polarity: Due to the presence of multiple hydroxyl (–OH) groups in its structure, the compound displays a degree of polarity which typically enhances solubility in polar solvents such as water.
  • Hydrogen Bonding: The -OH groups can form hydrogen bonds with water molecules, facilitating solubility in aqueous solutions.
  • Solvent Compatibility: This compound is likely to be more soluble in organic solvents such as alcohols and ethers, as its methoxy and phenoxy groups contribute to compatibility with organic media.
  • Temperature Dependence: Solubility can vary with temperature; generally, higher temperatures increase the solubility of solids in liquids.

In conclusion, while 3-(2-methoxyphenoxy)propane-1,2-diol shows good solubility in water due to its functional groups, it is also soluble in various organic solvents, making it a versatile compound for different applications. Understanding its solubility characteristics is crucial for its practical utilizations in chemical formulations.

Interesting facts

Interesting Facts about 3-(2-methoxyphenoxy)propane-1,2-diol

3-(2-methoxyphenoxy)propane-1,2-diol, also known as a complex organic compound, presents intriguing properties and applications that make it noteworthy in both scientific and industrial contexts. Here are some captivating aspects about this compound:

  • Structural Features: This compound includes a unique combination of a propane backbone with two hydroxyl (-OH) groups, which enhances its potential for hydrogen bonding and solubility in polar solvents.
  • Functional Versatility: The presence of both methoxy and phenoxy groups contributes to its reactivity and provides various pathways for functionalization in organic synthesis.
  • Biological Significance: Compounds similar to 3-(2-methoxyphenoxy)propane-1,2-diol have been explored for their potential role in biomedical applications, including drug delivery systems and as intermediates in pharmaceutical formulations.
  • Environmental Impact: Understanding its degradation and environmental interactions is crucial, as many phenolic compounds can impact ecosystems.
  • Research Potential: Ongoing research into compounds with similar structures evokes enthusiasm in fields such as materials science, for applications in creating novel polymers and additives.

As one delves into the study of 3-(2-methoxyphenoxy)propane-1,2-diol, it's vital to acknowledge the emblematic quote from renowned chemist, Linus Pauling: "The best way to have a good idea is to have lots of ideas." This compound is a testament to the endless possibilities in organic chemistry.

In summary, the versatility and potential application avenues of 3-(2-methoxyphenoxy)propane-1,2-diol underscore its importance in chemical research and industry. With ongoing studies, we continue to unlock the mysteries of similar compounds, establishing connections between chemistry and real-world innovations.

Synonyms
guaifenesin
93-14-1
Guaiphenesin
Guaiacol glyceryl ether
3-(2-methoxyphenoxy)propane-1,2-diol
GLYCERYL GUAIACOLATE
Methphenoxydiol
Glycerol guaiacolate
Guaiphenesine
Robitussin
Mucinex
Aeronesin
Breonesin
Bronchol
Hustosil
Aresol
Propanosedyl
Calmipan
Cortussin
Dorassin
Flartussin
Guaiacuran
Guaiacurane
Guaiamar
Guaianesin
Guaiphesin
Myocaine
Myoscain
Creson
Gaiamar
Hytuss
Myocain
Reduton
Dilyn
Resyl
Glycerin guaiacolate
3-(o-Methoxyphenoxy)-1,2-propanediol
Glyceryl guaiacol
Methoxypropanediol
Metossipropandiolo
Metfenossidiolo
Amonidrin
Glycotuss
Guaifenesine
Guajacuran
Guajamar
Guayanesin
Guiaphenesin
Hustodil
Mintosyl
Miocaina
Miocurin
Miorelax
Mucostop
Muskurelax
Myorelax
Myoscaine
Neuroton
Neurotone
Reorganin
Respenyl
Ritussin
Tenntuss
Glyceryl guaicolate
Glyceryl guiacolate
Guanar
Oresol
Oreson
Respil
Sirotol
Gvaja
Resil
Tolyn
Tulyl
Tulyn
Guaiacol glycerol ether
Guaiacolglicerinetere
Guaia-rom
Relaxil G
Relaxyl-G
Guaicol glyceryl ether
Gnaifenesin
Glyceryl guaiacyl ether
Guaiacyl glyceryl ether
Guaicol glycerine ether
Organidin NR
o-Methoxyphenyl glyceryl ether
Glycero-guaiacol ether
Guaiacol glycerin ether
Guaifenesina
Guaifenesinum
Amonidren
Pneumomist
1,2-Propanediol, 3-(2-methoxyphenoxy)-
Trecid
Glycerylguaiacol
Glyceryl guaiacolate ether
3-(2-Methoxyphenoxy)-1,2-propanediol
Glycerin monoguaiacol ether
Guajacol-glycerinaether
Glyceryl guaiacol ether
3-o-Methoxyphenoxypropane 1:2-diol
Glycerol mono(2-methoxyphenyl) ether
Guaifensin
rac Guaifenesin
Actifed C
Guaiacolic acid, ester with glycerol
MY 301
SL-90
XL-90
1,2-Propanediol, 3-(o-methoxyphenoxy)-
alpha-Glyceryl guaiacol ether
1,2-Dihydroxy-3-(2-methoxyphenoxy)propane
alpha-Glyceryl guaiacolate ether
G 87
Glycerol-alpha-guajakolether
NSC-62112
component of Quibron
3-(o-Methoxyphenoxy)-propanediol-1,2
component of Hycotuss
Glycerol .alpha.-guiacyl ether
.alpha.-Glyceryl guaiacol ether
Glycerol .alpha.-guaiacyl ether
Guajacol-.alpha.-glycerin-ether
component of Brondecon
DTXSID5023114
.alpha.-Glyceryl guaiacolate ether
CVT-2534
Glycerol .alpha.-monoguaiacol ether
NSC62112
component of Quibron Plus
MFCD00016873
1,2,3-Propanetriol, ether with 2-methoxyphenol
495W7451VQ
Glycerol .alpha.-(o-methoxyphenyl)ether
Glycerol .alpha.-(2-methoxyphenyl) ether
CHEBI:5551
component of Colrex Expectorant
DTXCID403114
2-G
2/G
OBREDON COMPONENT GUAIFENESIN
FLOWTUSS COMPONENT GUAIFENESIN
MUCINEX D COMPONENT GUAIFENESIN
MUCINEX DM COMPONENT GUAIFENESIN
Guaiphenezine
Equicol
Glycodex
Colrex expectorant
GUAIFENESIN (MART.)
GUAIFENESIN [MART.]
GUAIFENESIN (USP-RS)
GUAIFENESIN [USP-RS]
(+/-)-3-(O-METHOXYPHENOXY)-1,2-PROPANEDIOL
(R)-Guaifenesin
GUAIFENESIN (EP MONOGRAPH)
GUAIFENESIN [EP MONOGRAPH]
Tenntus
Tussin
GUAIFENESIN (USP MONOGRAPH)
GUAIFENESIN [USP MONOGRAPH]
Glycerinmonoguaiacol ether
Benylin-E
Lufyllin-GG
Aether glycerinoguaiacolicus
Guaifenesine [INN-French]
Guaifenesinum [INN-Latin]
Guajacol-alpha-glycerinether
Tedral Expectorant
(component of) Deconsal II
Glycerol alpha-guiacyl ether
Guaifenesina [INN-Spanish]
Glycerol alpha-guaiacyl ether
MY-301
Guaiacolate, Glycerol
Glycerol alpha-monoguaiacol ether
Glycerol-alpha-monoguaiacol ether
Guajacol-glycerinaether [German]
HSDB 3089
SR-01000737186
Glycerol mono(2-methoxyphenyl)ether
Ether, Guaiacol Glyceryl
Glyceryl Ether, Guaiacol
EINECS 202-222-5
Glycerol-alpha-guajakolether [Czech]
NSC 62112
Glycerol alpha-(o-methoxyphenyl)ether
Glycerol alpha-(o-methoxyphenyl) ether
Glycerol alpha-(2-methoxyphenyl) ether
BRN 2049375
Guiafenesin
Guifenesin
Gecolate
Guailaxin
Liqufruta
Pharbinex
WalgreenCherry
glycerin ether
Mucosa
Guaap
Mucus
Akin
BroncomarSF
Glyc
wal tussin
Sunmark Tussin
AI3-24947
Gadavyt Cough
Siltussin Sa
TusnelEX
Tussin Chest
Geri-Tussin
Muca Clear
Ultra Tuss
Air Power
Cough Out
Rompe PechoEX
Rompe PechoSF
UNII-495W7451VQ
DRx Choice
Mucosa Guifenesin
Q-Tussin
Reeses TABtussin
Guaifenesin,(S)
Mucus Relief Max
CVS Adult Mucus
Simpex Guaifenesin
Tussin Expectorant
welby mucus relief
CAS-93-14-1
Topcare Mucus ER
Leader Cough Tabs
NCGC00016350-01
Hustosil (TN)
Marcs Mucus Relief
Organ-I Nr
Topco Mucus Relief
Prestwick_231
TopCare Tab Tussin
basic care mucus er
careone mucus relief
Curist Mucus Relief
Guaifenesin 200mg
Guaifenesin 400mg
Kroger Mucus Relief
Palatos Expectorante
Ritussin Expectorant
Safrel Mucus Relief
Entex (Salt/Mix)
TussinEXPECTORANT
caring mill mucus er
Guaifenesin Injection
EXCAUGH
HUMABID
MucusExtended Release
MUCUSOL
Sunmark Mucus Relief
Dg Health Mucus ER
Dimacol (Salt/Mix)
Kwelcof (Salt/Mix)
Good Sense Mucus ER
Guaifenesin 200 mg
Guaifenesin 400 mg
Guaifenesin 600 mg
Robafen Cough Formula
(2S)-3-(2-methoxyphenoxy)propane-1,2-diol
Hycotuss (Salt/Mix)
DRx ChoiceFruit Punch
Childrens Mucus Relief
Guaifenesin [USAN:USP:INN:BAN:JAN]
Refenesen Mucus Relief
Brondecon (Salt/Mix)
Congestac (Salt/Mix)
Giltuss EX Expectorant
MucinexMaximum Strength
Selecthealth Tussin DM
Triaminic (Salt/Mix)
Broncomar ExpectorantSF
dg health mucus er max
Dilor G (Salt/Mix)
Geri-tussin Expectorant
Guaifenesin (Standard)
Guaifenesin 1200 mg
Kids-EEZEChest Relief
Rugby Cough Guaifenesin
Spectrum_000835
Pneumomist (Salt/Mix)
Q-Tussin (Salt/Mix)
12 Hour Mucus Relief
Glycerol-a-guajakolether
GUAIFENESIN-ODAAT
Mucus Relief 600 mg
3-(2-Methoxy-phenoxy)-propane-1,2-diol
basic care mucus er max
Mucinex D (Salt/Mix)
ROBITUSSIN (TN)
Adult Tussin Expectorant
Glycerol a-guiacyl ether
Meijer Adult Mucus Plus
MMM guaifenesin solution
Select Brand Tab Tussin
Tussar-2 (Salt/Mix)
Brexin EX (Salt/Mix)
Tussar SF (Salt/Mix)
Up and Up Mucus Relief
GUAIFENESIN [MI]
Guaifenesin(Guaiphenesin)
a-Glyceryl guaiacol ether
Glycerol a-guaiacyl ether
Mucinex DM (Salt/Mix)
Prestwick0_000776
Prestwick1_000776
Prestwick2_000776
Prestwick3_000776
Spectrum2_001104
Spectrum3_000444
Spectrum4_000566
Spectrum5_000758
GUAIFENESIN [INN]
GUAIFENESIN [JAN]
Lufyllin-GG (Salt/Mix)
Naldecon-EX (Salt/Mix)
GuaifenesinExtended Release
Select Brand Mucus Relief
(+-)-3-(o-Methoxyphenoxy)-1,2-propanediol
Guaifenesin (Guaiphenesin)
GUAIFENESIN [HSDB]
GUAIFENESIN [USAN]
CHEMBL980
Diabetic Tussin Expectorant
Guaifensin Extended-Release
Mucus and Chest Congestion
Theolair Plus (Salt/Mix)
GUAIFENESIN [VANDF]
Robitussin CF (Salt/Mix)
tussinadult chest congestion
tussinexpectorant for adults
SCHEMBL4321
a-Glyceryl guaiacolate ether
Betr chest congestion relief
careone mucus reliefchildrens
Guaifenesin Extended-Release
Mucus ReliefMaximum Strength
Neothylline-GG (Salt/Mix)
Quality Choice Mucus Relief
Gecolate, Glycodex Injection
Select Brand Coughtab 400
Oprea1_193170
Pneumotussin HC (Salt/Mix)
WLN: Q1YQ1OR BO1
1, 3-(o-methoxyphenoxy)-
Bronkaid Caplets (Salt/Mix)
BSPBio_000852
BSPBio_002088
COMPRESSO GGF 95 SA
Glycerol a-monoguaiacol ether
GUAIFENESIN [WHO-DD]
KBioGR_000972
KBioSS_001315
Mucus ReliefImmediate Release
Slo-Phyllin GG (Salt/Mix)
1,2-Propanediol, 3-(2-methoxyphenoxy)- (+-)-
4-06-00-05576 (Beilstein Handbook Reference)
Adult Tussin Chest Congestion
Maximum Strength Mucus Relief
MLS000028402
Mucus Relief Chest Congestion
Mucus Relief Extended Release
Mucus Relief Extended-Release
1, 3-(2-methoxyphenoxy)-
DivK1c_000248
SPECTRUM1500321
Glycerol-.alpha.-guajakolether
Meijer Chest Congestion Relief
Shopko Chest Congestion Relief
SPBio_001208
SPBio_002791
PV Tussin Tablet (Salt/Mix)
Tedral Expectorant (Salt/Mix)
BPBio1_000938
Foster and Thrive Mucus Relief
GTPL7617
wal tussinadult chest congestion
CVS Adult Mucuschest congestion
Guaifenesin (JP18/USP/INN)
TopCare Chest Congestion Relief
Berkley and Jensen Mucus Relief
Equaline Chest Congestion Relief
Good Neighbor Pharmacy Tabtussin
GUAIFENESIN [GREEN BOOK]
rugby mucus and chest congestion
Tussi-Organidin NR (Salt/Mix)
tussinmucus plus chest congestion
Childrens Giltuss EX Expectorant
Childrens MucinexChest Congestion
Good Neighbor Pharmacy Mucus ER
HMS500M10
HY-B0264R
KBio1_000248
KBio2_001315
KBio2_003883
KBio2_006451
KBio3_001308
Scot-tussin Expectorant Sf Cough
Childrens Chest Congestion Relief
Contac Cough Formula (Salt/Mix)
GUAIFENESIN [ORANGE BOOK]
R05CA03
Refenesen Chest Congestion Relief
Ru-Tuss DE Tablets (Salt/Mix)
Glycerol a-(o-methoxyphenyl)ether
GUAIFENESIN 400MG CAPLETS
GUAIFENESIN-ODAAT1200 MG
NINDS_000248
ROBITUSSIN CHEST CONGESTION
Tussin Mucus and Chest Congestion
Childrens Mucinex Chest Congestion
Healthmart Chest Congestion Relief
HMS1570K14
HMS1920B15
HMS2090K20
HMS2091H21
HMS2097K14
HMS2231M20
HMS3369E03
HMS3369N15
HMS3651I17
HMS3714K14
Isoclor Expectorant C (Salt/Mix)
Pharmakon1600-01500321
Polaramine Expectorant (Salt/Mix)
Robitussin Direct Chest Congestion
TussinGuifenesin Expectrorant Syrup
Rugby Chest Congestion ReliefG450
Curist Mucus ReliefMaximum Strength
Glycerol a-(2-methoxyphenyl) ether
Good Neighbor Pharmacy Mucus Relief
HY-B0264
LCA24875
CVS HEALTH Chest Congestion Relief
Leader Chest Congestion ReliefG450
Tox21_110389
Tox21_302094
BBL009981
Betr remedies chest congestion relief
CCG-39687
Guaifenesin Extended Release 600 mg
Guaifenesin Extended-Release 600 mg
NSC757052
s1740
STK365152
Glycerol, 1-(2-methoxyphenyl) ether
Premier Value Chest Congestion Relief
Tussinadult mucus and chest congestion
AKOS005435152
Childrens Mucus ReliefChest Congestion
Guaifenesin Extended-Release 1200 mg
Preferred Plus Chest Congestion Relief
Robitussin Mucus Plus Chest Congestion
Tox21_110389_1
Tussin Mucus and Chest CongestionAdult
DB00874
FG61559
GUAIFENESIN COMPONENT OF OBREDON
KS-5306
Meijer Adult Mucus Pluschest congestion
NSC-757052
Always Save Chest Congestion ReliefGUAF
Childrens Chest Congestion Relief Grape
Guaiacol glyceryl ether, >=98% (GC)
GUAIFENESIN COMPONENT OF FLOWTUSS
IDI1_000248
Mucus Relief Maximum Strength 1200 mg
3-(2-Methoxyphenoxy)-1, 2-propanediol
GUAIFENESIN COMPONENT OF HYCOFENIX
HYCOFENIX COMPONENT OF GUAIFENESIN
NCGC00094689-01
NCGC00094689-02
NCGC00094689-03
NCGC00094689-04
NCGC00094689-06
NCGC00255343-01
topcare tussinmucus plus chest congestion
AC-26819
CareOne TussinMucus Plus Chest Congestion
DA-73936
DG Health Immediate Release Mucus Relief
Foster and Thrive Chest Congestion Relief
GUAIFENESIN COMPONENT OF MUCINEX D
SMR000058387
SY001753
Akin Expectorant Formula Strawberry Banana
Equaline Tussin Mucus and Chest Congestion
good sense tussinmucus and chest congestion
GUAIFENESIN COMPONENT OF MUCINEX DM
SBI-0051397.P003
The Medicine Shoppe Chest Congestion Relief
AB00052006
Childrens MucinexMini-Melts Chest Congestion
G0159
Guaifenesin Extended-Release Tablets, 600mg
Mucus Relief Extended ReleaseMaximum Strength
NS00007812
SW196538-3
1,3-Propanetriol, ether with 2-methoxyphenol
Guaifensin Extended-Release Tablets, 1200 mg
(2RS)-3-(2-Methoxyphenoxy)propane-1,2-diol
D00337
D70850
EXPECTORANT GUAIFENESIN EXTENDED-RELEASE
Guaifenesin Directly compressible granules 95%
Ranolazine metabolite CVT-2534 (Guaifenesin)
3-{[2-(methyloxy)phenyl]oxy}propane-1,2-diol
AB00052006-10
AB00052006-11
AB00052006_12
AB00052006_13
A844457
EN300-25998675
MAX Tussin Mucus and Chest Congestion Sugar Free
Q420682
Crcle Guaifenesin Extended-Release Tablets, 600 mg
Crcle Guaifensin Extended Release Tablet, 1200 mg
SR-01000737186-2
SR-01000737186-3
Adult Tussin Mucus and Chest Congestion DM Sugar Free
BRD-A90515964-001-05-8
BRD-A90515964-001-09-0
BRD-A90515964-001-15-7
BRD-A90515964-001-16-5
MUCUS RELIEFGUAIFENESIN EXTENDED-RELEASE 600 mg
Mucinex ChildrensChest Congestion Mini-Melts Bubble Gum
Mucinex Fast-Max Chest Congestion Honey and Berry Flavor
MUCUS RELIEFGUAIFENESIN EXTENDED-RELEASE 1200 mg
Z1255415511
1,2-PROPANEDIOL, 3-(2-METHOXYPHENOXY)- (+/-)-
1,2-PROPANEDIOL, 3-(2-METHOXYPHENOXY)-(+/-)-
Guaifenesin, European Pharmacopoeia (EP) Reference Standard
Guaifenesin, United States Pharmacopeia (USP) Reference Standard
Little Remedies Little Colds Mucus Relief Expectorant Melt Aways
Guaifenesin, Pharmaceutical Secondary Standard; Certified Reference Material
Guaifenesin for peak identification, European Pharmacopoeia (EP) Reference Standard
202-222-5
Guaiacol glyceryl ether;Glycerol guaiacolate;3-(O-Methoxyphenoxy)-1,2-propanediol;3-(o-Methoxyphenoxy)-1,2-propanediol, guaiacol gly ceryl ether, robitussin;rac guaifenesin
InChI=1/C10H14O4/c1-13-9-4-2-3-5-10(9)14-7-8(12)6-11/h2-5,8,11-12H,6-7H2,1H