Skip to main content

Venlafaxine

ADVERTISEMENT
Identification
Molecular formula
C17H27NO2
CAS number
93413-69-5
IUPAC name
3-(2-methoxyphenoxy)-N-methyl-3-phenyl-propan-1-amine
State
State

Venlafaxine is a solid at room temperature.

Melting point (Celsius)
215.00
Melting point (Kelvin)
488.20
Boiling point (Celsius)
523.40
Boiling point (Kelvin)
796.60
General information
Molecular weight
277.40g/mol
Molar mass
277.4010g/mol
Density
1.3890g/cm3
Appearence

Venlafaxine is typically a white to off-white crystalline powder.

Comment on solubility

Solubility of 3-(2-methoxyphenoxy)-N-methyl-3-phenyl-propan-1-amine (C17H27NO2)

The solubility of 3-(2-methoxyphenoxy)-N-methyl-3-phenyl-propan-1-amine is a nuanced topic, as it is influenced by various factors including its molecular structure, functional groups, and interactions with solvents. This compound contains both hydrophobic and hydrophilic regions, leading to interesting solubility properties.

Key Points on Solubility:

  • Solvent Polarity: As an organic amine, this compound is likely to exhibit better solubility in non-polar or weakly polar organic solvents (e.g., ethyl acetate, dichloromethane) due to its hydrophobic phenyl groups.
  • Hydrophilic Aspects: The presence of the methoxy group may enhance solubility in polar solvents such as alcohols or dimethyl sulfoxide (DMSO), but less so in water.
  • Temperature Influence: Like many organic compounds, its solubility would typically increase with rising temperature, allowing for greater molecular motion and interaction with solvent molecules.
  • pH Dependency: The amine functionality can be affected by pH; in acidic solutions, it may become protonated, potentially changing its solubility characteristics significantly.

In summary, while 3-(2-methoxyphenoxy)-N-methyl-3-phenyl-propan-1-amine may show varying solubility based on its environment, it is generally less soluble in water due to its bulky hydrophobic regions.

Interesting facts

Interesting Facts about 3-(2-methoxyphenoxy)-N-methyl-3-phenyl-propan-1-amine

3-(2-methoxyphenoxy)-N-methyl-3-phenyl-propan-1-amine, often abbreviated as MPPA, is a fascinating compound with intriguing properties and applications in the field of chemistry.

Key Features

  • Structural Versatility: The compound contains a complex structure with multiple functional groups, including phenyl and methoxy groups. This gives it varied reactivity and potential applications in synthetic chemistry.
  • Pharmacological Interest: Due to its amine functional group, MPPA has attracted attention for its potential pharmacological properties, making it a candidate for research in developing new pharmaceuticals.
  • Reactivity and Interactions: The presence of both electron-donating (methoxy) and electron-withdrawing groups in its structure can modify the compound’s electronic properties, allowing it to engage in diverse chemical reactions.

Chemical Behavior

As a tertiary amine, MPPA can participate in a variety of reactions, including:

  • **Nucleophilic substitutions** that can form novel derivatives.
  • **Formation of complexes** with metal ions, enabling potential applications in coordinate chemistry.

Research and Development

Given its unique structure, MPPA is a focus of ongoing research aimed at understanding:

  • Mechanistic pathways of its pharmacological effects.
  • Its potential as a therapeutic agent for specific medical conditions.

In summary, the compound 3-(2-methoxyphenoxy)-N-methyl-3-phenyl-propan-1-amine stands out in the realm of chemical research for its intriguing structural features and potential implications in medicinal chemistry. As scientific exploration continues, MPPA may unveil new opportunities in both fundamental and applied chemistry.

Synonyms
Nisoxetine
53179-07-0
Nisoxetina
Compound 89218
3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-amine
Nisoxetinum
Nisoxetine [USAN:INN]
3-(2-Methoxyphenoxy)-N-methyl-3-phenylpropylamine
57226-61-6
NSC-283481
3-(o-Methoxyphenoxy)-N-methyl-3-phenylpropylamine
DL-N-Methyl-3-(o-methoxyphenoxy)-N-methyl-3-phenylpropylamine
DTXSID0045175
N-Methyl-gamma-(2-methylphenoxy)phenylpropanolamine
CHEBI:73410
17NV064B2D
NISOXETINE [INN]
NISOXETINE [USAN]
NSC 283481
COMPOUND-89218
Benzenepropanamine, gamma-(2-methoxyphenoxy)-N-methyl-
CHEMBL295467
DTXCID8025175
Compound 89218; NSC 283481
NCGC00015715-04
Nisoxetine Inhibitor
LY 94939
(+/-)-3-(O-METHOXYPHENOXY)-N-METHYL-3-PHENYLPROPYLAMINE
BENZENEPROPANAMINE, .GAMMA.-(2-METHOXYPHENOXY)-N-METHYL-, (+/-)-
CAS-53179-07-0
UNII-17NV064B2D
Nisoxetine (USAN/INN)
Prestwick0_000910
Prestwick1_000910
Prestwick2_000910
Prestwick3_000910
Lopac0_000901
BSPBio_000760
SCHEMBL124289
SPBio_002959
BPBio1_000836
GTPL4637
BDBM22417
HMS2089K13
EX-A9581
Tox21 110203
Tox21_110203
NSC283481
PDSP1_000507
PDSP2_000505
Tox21_110203_1
CCG-204983
DB09186
SDCCGSBI-0050876.P002
NCGC00015715-03
NCGC00015715-05
NCGC00015715-06
NCGC00015715-08
NCGC00015715-15
NCGC00024945-02
NCGC00024945-03
AS-16468
DA-56190
3(oMethoxyphenoxy)Nmethyl3phenylpropylamine
3(2Methoxyphenoxy)Nmethyl3phenylpropylamine
AB00514644
DLNMethyl3(omethoxyphenoxy)3phenylpropylamine
NS00002148
NMethylgamma(2methylphenoxy)phenylpropanolamine
D05173
AB00514644-07
Benzenepropanamine, gamma(2methoxyphenoxy)Nmethyl
N-methyl 3(o-methoxyphenoxy)-3-phenylpropylamine
N-methyl 3-(o-methoxyphenoxy)-3-phenylpropylamine
Q906885
[3-(2-methoxyphenoxy)-3-phenylpropyl](methyl)amine
N-methyl-3-phenyl-3-(o-methoxyphenoxy)-propylamine
BRD-A95696066-003-03-9
BRD-A95696066-003-06-2
BRD-A95696066-003-13-8
BENZENEPROPANAMINE, GAMMA-(2-METHOXYPHENOXY)-N-METHYL-, (+/-)-