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Phenylephrine

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Identification
Molecular formula
C9H13NO2
CAS number
59-42-7
IUPAC name
3-[2-(ethylamino)-1-hydroxy-ethyl]phenol
State
State
Phenylephrine is typically found in a solid state at room temperature. It is used as a medication, primarily as a decongestant, but it is also used in injectable form to increase blood pressure in unstable patients with hypotension.
Melting point (Celsius)
140.00
Melting point (Kelvin)
413.15
Boiling point (Celsius)
289.00
Boiling point (Kelvin)
562.15
General information
Molecular weight
167.21g/mol
Molar mass
167.2100g/mol
Density
1.0794g/cm3
Appearence

Phenylephrine is a white or almost white crystalline powder. It is soluble in water and alcohol, making it easy to incorporate into pharmaceutical formulations.

Comment on solubility

Solubility of 3-[2-(ethylamino)-1-hydroxy-ethyl]phenol (C9H13NO2)

The solubility of 3-[2-(ethylamino)-1-hydroxy-ethyl]phenol is an important characteristic that affects its usage in various applications. Generally, the solubility of this compound can be described as follows:

  • Polar Nature: Given the presence of hydroxyl (–OH) and amino (–NH2) groups, the compound displays a degree of polarity which suggests a certain level of solubility in polar solvents like water.
  • Hydrogen Bonding: The hydroxyl group allows for hydrogen bonding with water molecules, enhancing solubility.
  • Aliphatic Chain Influence: The ethylamino chain may hinder complete solubility in highly polar solvents due to hydrophobic interactions.
  • Solvent Dependence: The solubility in different solvents could vary significantly. For example, it may be more soluble in alcohols compared to aliphatic hydrocarbons.

In conclusion, while 3-[2-(ethylamino)-1-hydroxy-ethyl]phenol has polar characteristics allowing for moderate solubility in water, the overall solubility is influenced by the structure and type of solvent used. Testing in multiple environments is recommended to ascertain its solubility profile accurately.

Interesting facts

Interesting Facts about 3-[2-(ethylamino)-1-hydroxy-ethyl]phenol

3-[2-(ethylamino)-1-hydroxy-ethyl]phenol is a fascinating compound with both structural and functional attributes that catch the attention of chemists and researchers alike. This compound belongs to a class of chemicals known for their physiological relevance and potential application in medicinal and pharmaceutical industries. Here are some noteworthy points:

  • Structural Elaboration: The compound features a phenolic structure, which is significant in many biological systems, making it an interesting target for study due to its potential reactivity and interactions with biological macromolecules.
  • Biological Activities: Compounds like this one often exhibit varied biological properties, including antioxidant and antimicrobial activities, which can contribute to their utility in drug formulation and therapy development.
  • Functional Groups: The presence of the ethylamino and hydroxy groups enhances its chemical versatility, allowing it to engage in numerous chemical reactions. Such functional groups are crucial for establishing interactions within biological systems.
  • Pharmaceutical Potential: Due to its similarity to known drug molecules, it opens up avenues for further exploration in drug design, particularly in addressing neurotransmitter activities which can be influenced by amino alcohols.

Moreover, research on compounds like 3-[2-(ethylamino)-1-hydroxy-ethyl]phenol underscores the importance of structural biology, as the configuration of a single molecule can significantly impact its activity and efficacy as a therapeutic agent.

In summary, this compound is not just incredibly complex in its structure, but it also hints at vast possibilities in application within medicinal chemistry and pharmacology. As stated by renowned chemist Linus Pauling, "The best way to have a good idea is to have a lot of ideas," and exploring this compound could lead to groundbreaking discoveries.

Synonyms
Etilefrine
Etilefrin
709-55-7
Effortil
Ethylphenylephrine
Ethyladrianol
3-[2-(Ethylamino)-1-hydroxyethyl]phenol
N-Ethylnorphenylephrine
Ethyl noradrianol
Racemic etilefrine
Etilefrina
Etilephrine
dl-Etilefrin
Etilefrine [INN]
(+-)-Etilefrine
(+-)-Etilefrin
Etilefrina [DCIT]
Ethyl adrianol
Ethylefrine
Etilefrinum
Etilefrinum [Latin]
Corcanfol
Etilefrina [Spanish]
Etilefrin dl-form
m-Hydroxyphenylethanolethylamine
Etilefrinum [INN-Latin]
1-(3-Hydroxyphenyl)-2-(ethylamino)ethanol
ETILEFRINE-D5
Etilefrine [INN:BAN]
alpha-((Ethylamino)methyl)-m-hydroxybenzyl alcohol
1-(3'-Hydroxyphenyl)-2-ethylaminoethanol
EINECS 211-910-4
Corcanfol (TN)
ZB6F8MY53V
Etilefrine (INN)
S 40032
S 40032-7
Benzenemethanol, alpha-((ethylamino)methyl)-3-hydroxy-
ETILEFRIN [MI]
EINECS 233-359-9
m-Hydroxy-alpha-(ethylaminomethyl)benzyl alcohol
alpha-(m-Hydroxyphenyl)-beta-(ethylamino)ethanol
ETILEFRINE [WHO-DD]
(+/-)-ETILEFRINE
3-[2-(ethylamino)-1-hydroxy-ethyl]phenol
MLS000881153
709-55-7 (free base)
BENZYL ALCOHOL, alpha-((ETHYLAMINO)METHYL)-m-HYDROXY-
DTXSID1023029
EC 211-910-4
S-40032
.alpha.-((Ethylamino)methyl)-m-hydroxybenzyl alcohol
Etilefrinum (Latin)
S-40032-7
10128-36-6
Benzyl alcohol, .alpha.-((ethylamino)methyl)-m-hydroxy-
Benzenemethanol, .alpha.-[(ethylamino)methyl]-3-hydroxy-
Etiladrianol
SMR000685797
3-(2-(ethylamino)-1-hydroxyethyl)phenol
Etilefrinum (INN-Latin)
Ethylnorphenylephrine
(1)-alpha-((Ethylamino)methyl)-m-hydroxybenzyl alcohol
.ALPHA.-(M-HYDROXYPHENYL)-.BETA.-(ETHYLAMINO)ETHANOL
BENZENEMETHANOL, .ALPHA.-((ETHYLAMINO)METHYL)-3-HYDROXY-
UNII-ZB6F8MY53V
R,S-Ethylephrine
(+-)-Ethylephrine
Enamine_002760
(.+/-.)-Etilefrin
Prestwick0_001017
Prestwick1_001017
Prestwick2_001017
Prestwick3_001017
(.+/-.)-Etilefrine
Effortil depot perlongetten
cid_3306
Oprea1_593945
BSPBio_001173
CHEMBL86882
SCHEMBL150802
SPBio_003044
BPBio1_001291
DTXCID503029
NIOSH/DO5600010
BDBM97154
CHEBI:91518
C01CA01
HMS1401N10
HMS2233J17
HMS3370K09
HY-A0144
BBL027207
STL377784
AKOS000116366
AKOS022060703
DB08985
IDI1_007107
NCGC00179276-01
NCGC00179276-04
1ST11094
DA-63314
3-[2-(Ethylamino)-1-hydroxyethyl]phenol #
3-[2-(ethylamino)-1-oxidanyl-ethyl]phenol
AB00514701
CS-0017466
DO56000100
NS00004054
EN300-33921
D07931
G89724
AB00514701-08
Apha-((ethylamino)methyl)-3-hydroxybenzenemethanol
Q417873
benzene, 1-(2-ethylamino-1-hydroxy)ethyl-3-hydroxy-
BRD-A09925278-001-07-6
BRD-A09925278-003-03-1
BRD-A09925278-003-05-6
Z56836691
(+-)-alpha-((Ethylamino)methyl)-m-hydroxybenzyl alcohol
Benzyl alcohol, alpha-((ethylamino)methyl)-m-hydroxy-, (+-)
.alpha.-[(Ethylamino)methyl]-3-hydroxybenzenemethanol hydrochloride
Benzenemethanol, .alpha-[(ethylamino)methyl]-3-hydroxy-, hydrochloride
211-910-4