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Serotonin

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Identification
Molecular formula
C10H12N2O
CAS number
50-67-9
IUPAC name
3-(2-aminoethyl)-2-methyl-1H-indol-5-ol
State
State
Serotonin is typically found in a solid state at room temperature.
Melting point (Celsius)
214.00
Melting point (Kelvin)
487.15
Boiling point (Celsius)
533.20
Boiling point (Kelvin)
806.35
General information
Molecular weight
176.22g/mol
Molar mass
176.2150g/mol
Density
1.3500g/cm3
Appearence

Serotonin appears as a white to pale yellow crystalline solid or powder. It is hygroscopic and soluble in water.

Comment on solubility

Solubility Insights for 3-(2-aminoethyl)-2-methyl-1H-indol-5-ol (C10H12N2O)

The solubility of 3-(2-aminoethyl)-2-methyl-1H-indol-5-ol is a subject of interest due to its potential applications in various fields, including pharmaceuticals and bioengineering. Understanding the solubility characteristics of this compound helps in predicting its behavior in biological systems and its efficacy in medicinal contexts.

Factors Affecting Solubility:

  • Polarity: The presence of the amino group (-NH2) and hydroxyl group (-OH) contributes to the polarity of the molecule, which generally enhances solubility in polar solvents like water.
  • Hydrogen Bonding: The ability to form hydrogen bonds with water molecules is crucial. The hydroxyl and amino groups can both participate in hydrogen bonding, facilitating better solubility.
  • Molecular Structure: The indole ring structure can affect the overall solubility by altering the sterics and the electronic environment. The two methyl groups may also influence solubility by creating hydrophobic interactions.

Given these factors, it's likely that 3-(2-aminoethyl)-2-methyl-1H-indol-5-ol exhibits moderate to good solubility in water. This is instrumental for its potential usage, as compounds with enhanced solubility are often more bioavailable.

Conclusion:

In summary, the solubility of 3-(2-aminoethyl)-2-methyl-1H-indol-5-ol is influenced by several key factors, notably its polarity, capacity for hydrogen bonding, and molecular structure. Understanding these aspects is essential for researchers aiming to utilize this compound effectively in various applications.

Interesting facts

Interesting Facts about 3-(2-aminoethyl)-2-methyl-1H-indol-5-ol

3-(2-aminoethyl)-2-methyl-1H-indol-5-ol is a fascinating compound that underscores the intricate relationship between structure and function in organic chemistry. Here are some engaging insights into this unique chemical:

  • Biological Significance: This compound is a derivative of the indole family, known for its presence in many biological systems. Indoles often exhibit biological activities such as antitumor, antioxidant, and antimicrobial properties, making them essential in pharmaceuticals.
  • Structure-Activity Relationship (SAR): The specific arrangement of the aminoethyl side chain and the hydroxyl functional group greatly influences the compound's reactivity and interaction with biological targets. It is a prime example of how slight modifications in molecular structure can lead to significant changes in biological activity.
  • Synthesis Pathways: The synthesis of 3-(2-aminoethyl)-2-methyl-1H-indol-5-ol can be achieved through various methods, including reductive amination and cyclization reactions. Such synthetic routes are not only fascinating but serve as templates for the design of other similar compounds.
  • Potential Research Applications: Due to its structural characteristics, there is ongoing research into its potential applications in drug development. Researchers are particularly interested in its role as a building block in targeted therapies and as a lead compound in the discovery of new drugs.

In summary, 3-(2-aminoethyl)-2-methyl-1H-indol-5-ol exemplifies the beauty of organic chemistry and its substantial potential in medicinal applications. Its intriguing properties continue to inspire scientists and researchers alike!

Synonyms
2-Methyl-5-hydroxytryptamine
78263-90-8
2-Methyl-5-HT
2-Methylserotonin
3-(2-Aminoethyl)-2-methyl-1H-indol-5-ol
1H-Indol-5-ol, 3-(2-aminoethyl)-2-methyl-
2-Me 5-HT
2-Me-5-HT
CHEBI:31085
3-(2-Amino-ethyl)-2-methyl-1H-indol-5-ol
D77Z9HJT2U
CHEMBL266591
DTXSID80228927
2-Methyl-5-hydroxytryptamine; 2-Methylserotonin;2-Me-5-HT
MFCD00152134
Tocris-0558
Lopac-M-109
Biomol-NT_000098
UNII-D77Z9HJT2U
2-Me-5HT
Lopac0_000813
GTPL218
SCHEMBL399028
5-HT,2-Me
BPBio1_001361
DTXCID30151418
DDA26390
BDBM50014406
PDSP1_001520
PDSP2_001504
AKOS016362704
CCG-204897
SB38745
SDCCGSBI-0050790.P002
NCGC00015628-01
NCGC00015628-02
NCGC00015628-03
NCGC00015628-04
NCGC00015628-05
NCGC00024652-01
NCGC00024652-02
NCGC00024652-03
AC-30467
HY-19358
NS-01775
PD048535
DB-112218
Indol-5-ol, 3-(2-aminoethyl)-2-methyl-
CS-0015425
EN300-325733
Y11118
2-Methyl-5-HT; 2-Methylserotonin; 2-Me-5-HT
L000061
3-(2-AZANYLETHYL)-2-METHYL-1H-INDOL-5-OL
Q4596904
BRD-K64137799-003-01-7
BRD-K64137799-003-02-5