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Tryptamine-5-carboxamide

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Identification
Molecular formula
C11H13N3O
CAS number
14639-25-9
IUPAC name
3-(2-aminoethyl)-1H-indole-5-carboxamide
State
State

At room temperature, tryptamine-5-carboxamide is in a solid state.

Melting point (Celsius)
210.00
Melting point (Kelvin)
483.15
Boiling point (Celsius)
395.00
Boiling point (Kelvin)
668.15
General information
Molecular weight
203.24g/mol
Molar mass
203.2420g/mol
Density
1.2670g/cm3
Appearence

Tryptamine-5-carboxamide typically appears as a white to off-white crystalline powder. It is known for its crystalline solid structure, which is common among similar organic compounds.

Comment on solubility

Solubility of 3-(2-aminoethyl)-1H-indole-5-carboxamide (C11H13N3O)

The solubility of 3-(2-aminoethyl)-1H-indole-5-carboxamide showcases intriguing features, which are essential for various applications in the chemical and pharmaceutical fields. This compound generally exhibits moderate water solubility due to the presence of both hydrophilic and hydrophobic groups in its structure.

Factors Affecting Solubility:

  • Functional Groups: The amino group (-NH2) tends to enhance solubility in water, while the indole ring adds hydrophobic character.
  • pH of the Solution: Solubility can vary significantly with pH due to ionization of the amino group, which can further influence the compound’s stability and solubility in aqueous solutions.
  • Temperature: Increasing the temperature can improve solubility, as it typically increases molecular motion and interaction with the solvent.

In organic solvents, 3-(2-aminoethyl)-1H-indole-5-carboxamide tends to dissolve more readily, particularly in solvents such as ethanol or dimethyl sulfoxide (DMSO). As a result, the solubility varies significantly based on the solvent and conditions applied.

To summarize, the solubility characteristics of this compound are essential for its functionality in biological systems and chemical reactions, and they can be significantly influenced by environmental factors. Its versatile solubility profile bolsters its potential usage in various formulations.

Interesting facts

Interesting Facts about 3-(2-aminoethyl)-1H-indole-5-carboxamide

3-(2-aminoethyl)-1H-indole-5-carboxamide, also known as a derivative of indole, is a fascinating compound notable for its biological and medicinal significance. Here are some key points to consider:

  • Biological Relevance: This compound is recognized for its role in various biochemical pathways, particularly in relation to neurotransmitter modulation.
  • Medicinal Applications: Research indicates that derivatives of indole compounds may exhibit potential therapeutic effects, including anti-cancer properties and neuroprotective activities.
  • Structural Features: The indole ring system is a critical element, contributing to the compound’s unique properties. Indole’s ability to engage in various chemical interactions makes it a valuable scaffold in drug design.
  • Multifunctionality: Compounds containing aminoethyl groups often display increased solubility and can enhance bioavailability, making this compound a subject of interest in pharmacological studies.
  • Research Potential: Ongoing studies focus on its derivatives to explore novel therapeutic applications, particularly in treating neurodegenerative diseases.

As a student of chemistry, you might find it intriguing to explore the synthesis of this compound and its analogs. It presents a wonderful opportunity to understand indole chemistry and its implications in medicinal chemistry. As a mental note, remember: “The beauty of chemistry lies in its ability to connect molecular structures with biological functions.”

Synonyms
5-Carboxamidotryptamine
74885-09-9
3-(2-aminoethyl)-1H-indole-5-carboxamide
5-Carboxyamidotryptamine
5-Carboxamide tryptamine
5-CT
1H-Indole-5-carboxamide, 3-(2-aminoethyl)-
CHEBI:48292
3-(2-Aminoethyl-1H-indole-5-carboxamide
UNII-91H76044O0
CHEMBL18840
91H76044O0
3-(2-azanylethyl)-1H-indole-5-carboxamide
5-carboxamidotryptamine hydrochloride
[3H]-5-CT
3-(2-Aminoethyl)-1H-indole-5-carboxamide Hydrochloride; 5-CT
8K3
NCGC00024598-01
Tocris-0458
GTPL4
Lopac-C-117
Biomol-NT_000109
Lopac0_000352
[3h]-5-carboxamidotryptamine
[3H]-5-Carboxyamidotryptamine
BPBio1_001405
SCHEMBL2677791
[3H]-5-Carboxamide tryptamine
BDBM21392
DTXSID60996379
WKZLNEWVIAGNAW-UHFFFAOYSA-N
3-(2-AMINO-ETHYL)-1H-INDOLE-5-CARBOXYLIC ACID AMIDE
PDSP1_000774
PDSP2_000762
AKOS027380025
CCG-204447
SDCCGSBI-0050340.P002
NCGC00015182-01
NCGC00015182-02
NCGC00015182-03
NCGC00015182-04
NCGC00015182-05
NCGC00015182-09
NCGC00024598-02
NCGC00024598-03
FA162449
PD051007
A22556
3-(2-Aminoethyl)-1H-indole-5-carboximidic acid
3-(2-Aminoethyl)-1H-indole-5-carboxamide;5-CT
L000077
Q4639580
BRD-K92382976-050-01-1
BRD-K92382976-103-01-8